The structural characterization and biological activity of sulfamethoxazolyl-azo-p-cresol, its copper(ii) complex and their theoretical studies

2016 ◽  
Vol 40 (6) ◽  
pp. 5019-5031 ◽  
Author(s):  
Nilima Sahu ◽  
Dipankar Das ◽  
Sudipa Mondal ◽  
Suman Roy ◽  
Paramita Dutta ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Structural Characterization ◽  
Drug Action ◽  
Theoretical Studies

Sulfonamide-azophenol and its copper(ii) complex exhibit antimicrobial activity and interaction with DNA. Molecular docking was used to determine the mechanism of drug action.

scholarly journals BIOLOGICAL ACTIVITY AND MOLECULAR DOCKING OF 2’-BROMO-4-METHOXY-3-NITRO BENZIL, 2,2’-DIBROMO BENZIL, AND 4,4’-DICHLORO BENZIL

2018 ◽  
Vol 11 (8) ◽  
pp. 351
Author(s):  
Nithya G ◽  
Sudha R ◽  
Charles C Kanakam
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Cell Growth ◽  
Antibacterial Activities ◽  
Docking Studies ◽  
Cytotoxic Effects ◽  
Further Development ◽  
Antibacterial And Antioxidant Activity

Objective: A series of benzil compounds have been synthesized by oxidation of corresponding benzoins which in turn were prepared from respective aldehydes. Using this protocol, three new benzils were prepared in good-to-excellent yields and their biological activity has been delineated.Methods: Molecular docking studies were conducted to validate the obtained pharmacological data and to provide understandable evidence for the observed antimicrobial activity of all synthesized compounds. Several benzils exhibited excellent antimicrobial and cytotoxic activity. To determine the cytotoxic effects, we used an MTT viability assay.Results: The results showed that cell growth is significantly lower in extract-treated cells compared to untreated control. The effect of inhibition of cell growth was shown in different concentration dosages for cytotoxic, antibacterial, and antioxidant activity in vitro.Discussion: The antimicrobial activity results indicated that some of the tested compounds showed the most promising antibacterial activities. These observations may promote a further development of our research in this field. The antioxidant activity was also performed for the compound benzil and its substituted analogs.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

2019 ◽  
Vol 70 (10) ◽  
pp. 3603-3610
Author(s):  
Madalina Mihalache ◽  
Cornelia Guran ◽  
Aurelia Meghea ◽  
Vasile Bercu ◽  
Ludmila Motelica ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Copper Complexes ◽  
Substrate Adhesion ◽  
Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]�H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.

Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity

2018 ◽  
Vol 69 (4) ◽  
pp. 815-822 ◽  
Author(s):  
Lucia Pintilie ◽  
Amalia Stefaniu ◽  
Alina Ioana Nicu ◽  
Maria Maganu ◽  
Miron Teodor Caproiu
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Molecular Docking ◽  
Drug Discovery ◽  
Elemental Analysis ◽  
Docking Studies ◽  
Receptor Protein ◽  
Chemical Methods ◽  
Design Synthesis ◽  
Gram Negative

A new series of fluoroquinolone compounds have been obtained by Gould-Jacobs method. The compounds have been characterized by physic-chemical methods (elemental analysis, FTIR, NMR, UV-Vis) and by antimicrobial activity against Gram-positive and Gram-negative microorganisms. For the synthesized compounds have been performed calculations of characteristics and molecular properties, using Spartan�14 Software from Wavefunction, Inc. Irvine, CA. and molecular docking studies using CLC Drug Discovery Workbench 2.4 software, to identify and visualize the most likely interaction ligand (fluoroquinolone) with the receptor protein.

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