Polyethylene glycol-400/H3PO2: an eco-friendly reductive system for the synthesis of selanylesters

2015 ◽  
Vol 2 (11) ◽  
pp. 1531-1535 ◽  
Author(s):  
G. Perin ◽  
M. B. Silveira ◽  
A. M. Barcellos ◽  
R. G. Jacob ◽  
D. Alves
Keyword(s):  
Polyethylene Glycol ◽  
Green Method ◽  
Polyethylene Glycol 400 ◽  
Hypophosphorous Acid ◽  
Acyl Chlorides ◽  
Peg 400

An alternative green method was described for the synthesis of selanylesters by reactions of acyl chlorides with arylselenols, generated in situ by reaction of diaryl diselenides with hypophosphorous acid (H3PO2) using polyethylene glycol-400 (PEG-400) as the solvent.

scholarly journals Elemental Chalcogen (Se, S) in PEG-400 to the Synthesis of Seleno- and Thioflavones from 2-Chlorophenyl Ethynyl Ketone and Nucleophilic Species of Chalcogen

2021 ◽  
Author(s):  
Patrick Nobre ◽  
Thiago Peglow ◽  
Ricardo Bartz ◽  
Angelita Barcellos ◽  
Raquel Jacob ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Sodium Atom ◽  
Simple Approach ◽  
Ring Closure ◽  
Green Method ◽  
Polyethylene Glycol 400 ◽  
Alkyl Aryl ◽  
Peg 400 ◽  
Ethynyl Ketone

An alternative green method was developed for the synthesis of thio- and selenoflavones by the ring closure of 2-chlorophenyl ethynyl ketone with NaHY (Y = S, Se). These nucleophilic chalcogen species were generated in situ using NaBH4 to reduce the elemental chalcogen in the presence of polyethylene glycol-400 (PEG-400). The efficiency of this reaction is strongly dependent on the PEG-400 solvent, acting like a crown ether, complexing with the sodium atom of NaHY species, making the chalcogen nucleophile more active. The synthetic protocol proceeded efficiently at 100 °C under argon, using a range of 2-chlorophenyl ethynyl ketone containing alkyl, aryl, or vinyl groups and the sulfur and selenium chalcogen. By this efficient and simple approach, 18 chalcogenoflavones were obtained in good to excellent yields after 2 h.

Solubility and Thermodynamics of 6-Phenyl-4,5-dihydropyridazin-3(2H)-one in Various (PEG 400+Water) Mixtures

2019 ◽  
Vol 233 (2) ◽  
pp. 273-287 ◽  
Author(s):  
Mohd. Imran
Keyword(s):  
Polyethylene Glycol ◽  
Thermodynamic Analysis ◽  
Mole Fraction ◽  
Solubility Data ◽  
Polyethylene Glycol 400 ◽  
Isothermal Method ◽  
Peg 400 ◽  
Neat Water

Abstract The aim of this study was to determine the solubility of pyridazinone derivative 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) in different “polyethylene glycol 400 (PEG 400)+water” mixtures at temperatures “T=293.2 K to 313.2 K” and pressure “p=0.1 MPa”. The solubilities of PDP-6 were determined using an isothermal method and correlated with Apelblat, van’t Hoff and Yalkowsky–Roseman models. The maximum solubilities of PDP-6 in mole fraction were obtained in neat PEG 400 (8.46×10−2 at T=313.2 K). However, the minimum one was recorded in neat water (7.50×10−7 at T=293.2 K). Apparent thermodynamic analysis showed an endothermic dissolution of PDP-6 in all (PEG 400 water) mixtures. Based on the solubility data of the current study, PDP-6 has been considered as practically insoluble in water and soluble in PEG 400.

Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in fischer-344 rats

1995 ◽  
Vol 33 (2) ◽  
pp. 139-149 ◽  
Author(s):  
S.J. Hermansky ◽  
D.A. Neptun ◽  
K.A. Loughran ◽  
H.W. Leung
Keyword(s):  
Polyethylene Glycol ◽  
Fischer 344 Rats ◽  
Polyethylene Glycol 400 ◽  
Fischer 344 ◽  
Peg 400

scholarly journals Synthesis of Substituted by Using Sodium Thiosulfate in Polyethylene Glycol 400 (PEG-400)

2013 ◽  
Vol 4 (1) ◽  
pp. 299-299
Author(s):  
Muhammad Taha ◽  
Nor Hadiani Ismail ◽  
Faridahanim Mohd Jaafar ◽  
Khalid Mohammed Khan
Keyword(s):  
Polyethylene Glycol ◽  
Sodium Thiosulfate ◽  
Polyethylene Glycol 400 ◽  
Peg 400

Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

RSC Advances ◽  
2015 ◽  
Vol 5 (28) ◽  
pp. 22168-22172 ◽  
Author(s):  
Md. Nasim Khan ◽  
Shaik Karamthulla ◽  
Lokman H. Choudhury ◽  
Md. Serajul Haque Faizi
Keyword(s):  
Polyethylene Glycol ◽  
Multicomponent Reactions ◽  
Reaction Medium ◽  
Green Method ◽  
One Pot ◽  
Peg 400 ◽  
Ultrasound Assisted

A simple and benign one-pot protocol for the synthesis of 2-amino selenopyrindine derivatives 4 has been developed using ultrasound assisted multicomponent reactions of aldehydes, malononitrile and benzeneselenol in PEG-400.

Studies on the Processing Conditions for Preparation of Polyol Using Beet Pulp

2012 ◽  
Vol 189 ◽  
pp. 7-11
Author(s):  
Xiao Lin Yan ◽  
Ke Bing Wang
Keyword(s):  
Polyethylene Glycol ◽  
Weight Ratio ◽  
Processing Conditions ◽  
Silicotungstic Acid ◽  
Polyethylene Glycol 400 ◽  
Catalyst Amount ◽  
Peg 400 ◽  
Beet Pulp ◽  
Liquefaction Temperature ◽  
Solid Liquid

The catalyzed liquefaction degradation of beet pulp (BP) had been studied in the system of solid silicotungstic acid and polyethylene glycol 400 (PEG400)/glycerol (GLY), in which the solid silicotungstic acid served as the catalyst, and the latter was the complex liquefacient. This paper investigated the influence of processing conditions of BP liquefaction on the liquefaction reaction and the properties of liquefaction product. The results showed that BP had a good liquefaction effect, and the optimum liquefaction processing conditions were founded as follows: the weight ratio of PEG 400/glycerol was 4:1, the liquefaction temperature was 175oC, the catalyst amount was 8%wt, the solid-liquid weight ratio was 1:12, and the liquefaction time was 135 min. In these conditions, it was found that the best liquefaction rate would reach 99.5%, the hydroxyl and acid values of liquefaction mixtures were 52-82mg/g and 0.61-0.75mg/g respectively, the final products were lower hydroxyl value plant-based polyol.

scholarly journals Copper-catalyzed cyanation of aryl halides with sodium nitroprusside in polyethylene glycol 400 (PEG-400)

ARKIVOC ◽  
2016 ◽  
Vol 2016 (5) ◽  
pp. 13-21 ◽  
Author(s):  
Minhua Jiang ◽  
Tangjun Yuan ◽  
Fei Yi ◽  
Junmin Chen
Keyword(s):  
Polyethylene Glycol ◽  
Sodium Nitroprusside ◽  
Aryl Halides ◽  
Polyethylene Glycol 400 ◽  
Peg 400

scholarly journals Characterization of Nanosilver Biosynthesis by Citrus sinensis (L.) Osbeck and Peel-off Mask Formulation with Variation Polyethylene Glycol 400-Glycerin Concentration

2022 ◽  
Vol 1 ◽  
pp. 47
Author(s):  
Dian Eka Ermawati ◽  
Agung P. Surya ◽  
Adi Yugatama
Keyword(s):  
Particle Size ◽  
Polyethylene Glycol ◽  
Physicochemical Properties ◽  
Citrus Sinensis ◽  
Ph Value ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Polyethylene Glycol 400 ◽  
Peg 400

Sweet orange contains flavonoids and citric acid that have the potential as a capping agent in the nanosilver biosynthesis process. The antibacterial activity of silver can be increased in nanoparticles, then it can be applied to treat acne through a peel-off mask preparation. Glycerin and Polyethylene glycol 400 are humectants that combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of nanosilver biosynthesis and the effect of humectant combination on the physicochemical properties of the preparation. The characterization of nanosilver was employed by UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The Glycerin- PEG 400 combination was F1 (0:100%); F2 (25:75%); F3 (50:50%); F4 (75:25%) and F5 (100:0%). The results of nanosilver biosynthesis have an absorption peak of nanoparticles at 421-423nm, rod shape, the particle size of 83.2±7.2nm. Statistical analysis showed that the combination of Glycerin- PEG 400 had a significant effect on organoleptic, viscosity, and dry time, but did not affect the pH of preparation. The combination of Glycerin-PEG 400 (75%:25%) is the best formula because it has stable viscosity, dry time, and pH value during storage for four weeks.Keywords: nanosilver, biosynthesis, Citrus sinensis, humectants, peel off mask

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