Lanthanide-induced shift reagents enable the structural elucidation of natural products in inseparable complex mixtures – the case of elemenal from Inula helenium L. (Asteraceae)

RSC Advances ◽  
2015 ◽  
Vol 5 (89) ◽  
pp. 72670-72682 ◽  
Author(s):  
Marija S. Genčić ◽  
Niko S. Radulović
Keyword(s):  
Natural Products ◽  
Structural Elucidation ◽  
Complex Mixtures ◽  
New Approach ◽  
Inula Helenium ◽  
Shift Reagents

A new approach to the structural elucidation of constituent(s) of complex mixtures was developed based on the use of lanthanide-induced shift reagents. This methodology was successfully applied in the identification of a rare sesquiterpene elemenal.

Multitarget Affinity/Specificity Screening of Natural Products:  Finding and Characterizing High-Affinity Ligands from Complex Mixtures by Using High-Performance Mass Spectrometry

2003 ◽  
Vol 66 (9) ◽  
pp. 1186-1190 ◽  
Author(s):  
Lendell L. Cummins ◽  
Shuo Chen ◽  
Larry B. Blyn ◽  
Kristin A. Sannes-Lowery ◽  
Jared J. Drader ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
High Performance ◽  
Complex Mixtures ◽  
Affinity Ligands ◽  
High Affinity

scholarly journals Very Long-Range Correlations (nJC,H n > 3) in HMBC Spectra

2008 ◽  
Vol 3 (3) ◽  
pp. 1934578X0800300
Author(s):  
Ramiro Araya-Maturana ◽  
Hernán Pessoa-Mahana ◽  
Boris Weiss-López
Keyword(s):  
Natural Products ◽  
Long Range ◽  
Organic Molecules ◽  
Heteronuclear Nmr ◽  
Structural Elucidation ◽  
Coupling Constants ◽  
Contour Plot ◽  
Long Range Correlations ◽  
Complex Organic

The structural elucidation of natural products and complex organic molecules relies heavily on the application of proton detected heteronuclear NMR. Among these techniques, the HMBC NMR experiment remains as the most popular among the methods that sample long range coupling constants. The HMBC (C-H) experiment allows the assignment of structural fragments through correlations between protons and carbons separated by more than one bond, usually two or three (2 JC,H and 3 JC,H). It is also possible to obtain valuable information, sometimes crucial, through very long-range, or nonstandard correlations, n JC,H n>3; they can, surprisingly, appear in standard HMBC spectra, or looked for by performing several HMBC experiments with different long-range delays and using a deeper threshold in the contour plot.

scholarly journals Dendrimers as Drug Carriers. A New Approach to Increase the Potential of Bioactive Natural Products

2006 ◽  
Vol 1 (7) ◽  
pp. 1934578X0600100
Author(s):  
Costas Demetzos
Keyword(s):  
Natural Products ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Water Soluble ◽  
World Health ◽  
New Approach ◽  
Bioactive Natural Products ◽  
The World ◽  
Poorly Water Soluble ◽  
Health Organization

Nanotechnology is a challenging field in science and its application in medicine will bring significant advantages in the treatment of diseases. According to the World Health Organization there is a need for improved therapies against cancer, AIDS and Alzheimer's disease. The new therapies include the design of drug delivery systems, which are able to deliver new bioactive natural products to the target tissues. Dendrimers are hyperbranched polymers with well defined structure and molecular weight; they are composed of a central core and repeated branching units; they have a globular shape, low polydispersity and large void internal spaces that can be used for the encapsulation and delivery of many classes of compounds. Nanosystems, such as dendrimers, can achieve successful administration of poorly water-soluble compounds and those with narrow therapeutic indices.

scholarly journals 193 nm Ultraviolet Photodissociation Mass Spectrometry for the Structural Elucidation of Lipid A Compounds in Complex Mixtures

2014 ◽  
Vol 86 (4) ◽  
pp. 2138-2145 ◽  
Author(s):  
John P. O’Brien ◽  
Brittany D. Needham ◽  
Jeremy C. Henderson ◽  
Emily M. Nowicki ◽  
M. Stephen Trent ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lipid A ◽  
Structural Elucidation ◽  
Complex Mixtures ◽  
Ultraviolet Photodissociation ◽  
193 Nm

scholarly journals Total synthesis and structural elucidation of natural products: (–)-Delactonmycin, (+)-plumerinine, and (–)-parvistemoamide

2005 ◽  
Vol 77 (7) ◽  
pp. 1153-1160 ◽  
Author(s):  
Ronaldo A. Pilli ◽  
Ivan R. Corrêa ◽  
Adriano O. Maldaner ◽  
Giovanni B. Rosso
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Inhibitory Activity ◽  
Structural Elucidation ◽  
Relative Configuration ◽  
Synthetic Studies ◽  
Hiv 1 ◽  
Rev Protein

Synthetic studies that established the relative configuration of (–)-delactonmycin, a polyketide with inhibitory activity against HIV-1 Rev protein, and our efforts toward the structural elucidation of the alkaloids (+)-plumerinine, isolated from P. rubra, and (–)-parvistemoamide, isolated from S. parviflora, are discussed.

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