Long‐Term Retarded Release for the Proteasome Inhibitor Bortezomib through Temperature‐Sensitive Dendritic Glycopolymers as Drug Delivery System from Calcium Phosphate Bone Cement

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

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Evaluation of a Novel Osteoporotic Drug Delivery System In Vitro: Alendronate-Loaded Calcium Phosphate Cement

Orthopedics ◽

10.3928/01477447-20100625-15 ◽

2010 ◽

Cited By ~ 4

Author(s):

Zhao Jindong ◽

Tang Hai ◽

Gu Junchao ◽

Wang Bo ◽

Bao Li ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Drug Delivery System ◽

Delivery System ◽

Calcium Phosphate Cement

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Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Drug Delivery and Translational Research ◽

10.1007/s13346-019-00686-3 ◽

2019 ◽

Vol 10 (2) ◽

pp. 455-470 ◽

Cited By ~ 6

Author(s):

Magdalena Prokopowicz ◽

Adrian Szewczyk ◽

Adrianna Skwira ◽

Rafał Sądej ◽

Gavin Walker

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Simulated Body Fluid ◽

Mesoporous Silica ◽

Drug Delivery System ◽

Delivery System ◽

Body Fluid ◽

Molecular Surface ◽

Molar Ratio ◽

Mineralization Potential

AbstractWe reported the new biphasic composites of calcium phosphate and mesoporous silica material (CaP@MSi) in the form of powders and pellets as a potential bone drug delivery system for doxycycline hydrochloride (DOX). The CaP@MSi powders were synthesized by cationic surfactant-templating method. The effects of 10, 20, and 30% CaP content in the CaP@MSi powders on the molecular surface structure, the cytotoxicity against osteoblast cells in vitro, and the mineralization potential in simulated body fluid were investigated. The CaP@MSi characterized by the highest mineralization potential (30% CaP content) were used for DOX adsorption and pelletization process. The CaP which precipitated in the CaP@MSi composites was characterized as calcium-deficient with the Ca:P molar ratio between 1.0 and 1.2. The cytotoxicity assays demonstrated that the CaP content in MSi increases osteoblasts viability indicating the CaP@MSi (30% CaP content) as the most biocompatible. The combination of CaP and MSi was an effective strategy to improve the mineralization potential of parent material. Upon immersion in simulated body fluid, the CaP of composite converted into the bone-like apatite. The obtained pellets preserved the mineralization potential of CaP@MSi and provided the prolonged 5-day DOX release. The obtained biphasic CaP@MSi composites seem to have an application potential as bone-specific drug delivery system.

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Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

Journal of Materials Chemistry B ◽

10.1039/c8tb02952k ◽

2019 ◽

Vol 7 (14) ◽

pp. 2261-2276 ◽

Cited By ~ 3

Author(s):

Yufei Bian ◽

Zhiyong Wei ◽

Zefeng Wang ◽

Zhu Tu ◽

Liuchun Zheng ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Physical Properties ◽

Drug Delivery System ◽

Delivery System ◽

Controlled Drug Release ◽

Biodegradable Polyesters ◽

Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

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