Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 10001-10010 ◽  
Author(s):  
Prakash Chandra Bhatt ◽  
Pranay Srivastava ◽  
Preeti Pandey ◽  
Washim Khan ◽  
Bibhu Prasad Panda
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Pc12 Cells ◽  
Solid Lipid Nanoparticles ◽  
Dosage Form ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid ◽  
Biological Studies ◽  
Conventional Dosage

Astaxanthin nanoformulation was found appropriate in all measures with strong antioxidant activity against H2O2induced oxidative stress in PC12 cells. Biodistribution and brain delivery was also found to be superior to conventional dosage form.

Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies

2012 ◽  
Vol 439 (1-2) ◽  
pp. 49-62 ◽  
Author(s):  
Susana Martins ◽  
Ingunn Tho ◽  
Isolde Reimold ◽  
Gert Fricker ◽  
Eliana Souto ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Formulation Design ◽  
Solid Lipid

Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy

2017 ◽  
Vol 152 ◽  
pp. 296-301 ◽  
Author(s):  
Giovanna Rassu ◽  
Elena Soddu ◽  
Anna Maria Posadino ◽  
Gianfranco Pintus ◽  
Bruno Sarmento ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid
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