Highly sensitive detection of cancer-related genes based on complete fluorescence restoration of a molecular beacon with a functional overhang

The Analyst ◽  
2016 ◽  
Vol 141 (14) ◽  
pp. 4417-4423 ◽  
Author(s):  
Feng Li ◽  
Ying-Ying Zhou ◽  
Ting Peng ◽  
Huo Xu ◽  
Rong-Bo Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Molecular Beacon ◽  
Sensitive Detection ◽  
Cancer Gene ◽  
Strand Displacement ◽  
Gene Diagnosis ◽  
Sensing System ◽  
Complete Restoration ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

A overhang-contained molecular beacon-based sensing system was developed for cancer gene diagnosisviaexecuting cyclical nucleic acid strand-displacement polymerization and complete restoration of the quenched fluorescence.

scholarly journals Highly Sensitive Detection of Dengue Virus Nucleic Acid in Samples from Clinically Ill Patients

2009 ◽  
Vol 47 (4) ◽  
pp. 927-931 ◽  
Author(s):  
J. L. Munoz-Jordan ◽  
C. S. Collins ◽  
E. Vergne ◽  
G. A. Santiago ◽  
L. Petersen ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dengue Virus ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

scholarly journals A smart fluorescent biosensor for the highly sensitive detection of BRCA1 based on a 3D DNA walker and ESDR cascade amplification

RSC Advances ◽  
2019 ◽  
Vol 9 (34) ◽  
pp. 19347-19353 ◽  
Author(s):  
Hongmin Ma ◽  
Bin Guo ◽  
Xiaoyu Yan ◽  
Tong Wang ◽  
Haiying Que ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Sensitive Detection ◽  
Fluorescent Biosensor ◽  
Dna Walker ◽  
Highly Sensitive ◽  
Nucleic Acid Analysis ◽  
Highly Sensitive Detection ◽  
Cascade Amplification ◽  
Diagnosis Of Diseases

Nucleic acid analysis plays an important role in the diagnosis of diseases.

Label-free and highly sensitive detection of DNA adenine methylation methyltransferase through cathodic photoelectrochemistry

The Analyst ◽  
2021 ◽  
Author(s):  
Fang Li ◽  
Xiu-Ming Wu ◽  
Mengmeng Gu ◽  
Guang-Li Wang
Keyword(s):  
Potassium Ferricyanide ◽  
Sensitive Detection ◽  
Label Free ◽  
Sensing System ◽  
Highly Sensitive ◽  
Adenine Methylation ◽  
Highly Sensitive Detection

In this work, we report the first exploration of cathodic photoelectrochemistry for the determination of the activity of DNA adenine methylation (Dam) methyltransferase (MTase). In this sensing system, potassium ferricyanide...

An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

2018 ◽  
Vol 54 (77) ◽  
pp. 10897-10900 ◽  
Author(s):  
Zhi-Bin Wen ◽  
Wen-Bin Liang ◽  
Ying Zhuo ◽  
Cheng-Yi Xiong ◽  
Ying-Ning Zheng ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Nucleic Acid ◽  
Signal Amplification ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Strand Displacement ◽  
Microrna Detection ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Amplification Strategy

Herein, an adenosine triphosphate (ATP)-fueled nucleic acid signal amplification strategy based on toehold-mediated strand displacement (TMSD) and fluorescence resonance energy transfer (FRET) was proposed for highly sensitive detection of microRNA-21.

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