Epoxidation using molecular oxygen in flow: facts and questions on the mechanism of the Mukaiyama epoxidation

2016 ◽  
Vol 6 (13) ◽  
pp. 4724-4732 ◽  
Author(s):  
Laurent Vanoye ◽  
Jiady Wang ◽  
Mertxe Pablos ◽  
Claude de Bellefon ◽  
Alain Favre-Réguillon
Keyword(s):  
Molecular Oxygen ◽  
Continuous Flow ◽  
Room Temperature ◽  
Flow Microreactor

Mukaiyama reaction was performed G/L continuous-flow microreactor. In less than 5 minutes at room temperature, cyclooctene was efficiently transformed to the corresponding epoxide using O2 as oxidant and aldehyde as co-reductant.

Rapid and Efficient Coupling Reaction of Azo Dyes in a Continuous-Flow Microreactor

2012 ◽  
Vol 560-561 ◽  
pp. 516-520
Author(s):  
Wu Bin Yu ◽  
Ming Ming Zheng ◽  
Jian Rong Gao
Keyword(s):  
Reaction Time ◽  
Azo Dyes ◽  
Continuous Flow ◽  
Room Temperature ◽  
High Efficiency ◽  
Coupling Reaction ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
Flow Microreactor ◽  
Efficient Coupling

A convenient, rapid efficient method for the synthesis of azo dyes has been developed by coupling in a continuous-flow microreactor at room temperature. The advantage of this protocol is its continuousness, high efficiency and selectivity, short reaction time, and milder reaction conditions.

scholarly journals Continuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones

2019 ◽  
Vol 84 (6) ◽  
pp. 531-538 ◽  
Author(s):  
Julijana Tadic ◽  
Marina Mihajlovic ◽  
Mica Jovanovic ◽  
Dusan Mijin
Keyword(s):  
1H Nmr ◽  
Retention Time ◽  
Industrial Production ◽  
Continuous Flow ◽  
Room Temperature ◽  
Melting Points ◽  
Flow Rates ◽  
Flow Synthesis ◽  
Flow Microreactor ◽  
Ft Ir

In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2- -pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, 1H-NMR and UV?Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

Transformation of 1-Butene over Synthetic Zeolites

1992 ◽  
Vol 57 (4) ◽  
pp. 869-881 ◽  
Author(s):  
Italo Ferino ◽  
Roberto Monaci ◽  
Vincenzo Solinas ◽  
Lucio Forni ◽  
Antonio Rivoldini ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Continuous Flow ◽  
Liquid Mixture ◽  
Isomerization Reaction ◽  
Reaction Conditions ◽  
Title Reaction ◽  
Y Zeolites ◽  
Temperature Range ◽  
Flow Microreactor ◽  
Synthetic Zeolites

The behaviour of several zeolites as catalysts for the title reaction has been investigated by means of a continuous flow microreactor. Runs performed at atmospheric pressure indicated that at 423 K the completely protonic forms of the zeolites catalyze just the isomerization reaction. In the case of Y zeolites, oligomerization occurs only over the partially decationated samples, in the temperature range between 373 and 423 K and W/F between 0.2 and 22 gcath/g1-but, to an extent which depends on the reaction conditions. Most of the catalysts were tested also under pressure (4.05 MPa) at 423 K. The protonic forms of Y and ZSM-5 zeolites seem promising catalysts in terms of both conversion and selectivity to oligomers. The 1-olefins account for 30% of the entire olefinic mixture. The octenes, which account for 70% of the liquid mixture, are mostly formed of dimethylhexenes. Trimers are also formed during the reaction and, in the very particular case of H[B]ZSM-5, tetramers are produced.

scholarly journals Dynamic characterization of nanoparticles production in a droplet-based continuous flow microreactor

2019 ◽  
Vol 144 ◽  
pp. 247-257 ◽  
Author(s):  
Haiyun Ma ◽  
Nan Jin ◽  
Peng Zhang ◽  
Yufei Zhou ◽  
Yuchao Zhao ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Dynamic Characterization ◽  
Flow Microreactor

Rapid high conversion of high free fatty acid feedstock into biodiesel using continuous flow vortex fluidics

RSC Advances ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 2276-2280 ◽  
Author(s):  
Joshua Britton ◽  
Colin L. Raston
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Continuous Flow ◽  
Room Temperature ◽  
Flow Chemistry ◽  
Environmentally Benign ◽  
High Free Fatty Acid ◽  
Rapid Reduction ◽  
Biodiesel Feedstock ◽  
Flow Vortex

Rapid reduction of free fatty acids in biodiesel feedstock: the rapid conversion of problematic free fatty acids in bio-oils has been achieved using room temperature, environmentally benign vortex fluidic flow chemistry.

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