Plasma free reversible and irreversible microfluidic bonding

In this paper, a novel method for manufacturing flexible microfluidic chips without bonding process is proposed, which combines 3D printing technology and material dissolution technology. The manufacturing process of the microfluidic chip is as follows: a soluble HIPS mold with a preset shape is manufactured by 3D printing and placed in a molten PDMS solution for solidification. Soak in the limonene material to dissolve the mold and form a microchannel in the cured PDMS. Experimental studies have shown that the temperature and concentration of the limonene solution have an important effect on the dissolution rate. A 0.62 cm3 HIPS mold has the fastest dissolution rate at 100°C and 50% concentration. The proposed method provided a new idea for fabricating flexible microfluidic chip. Compared to bonding process, it has the characteristics of not relying on complicated processing conditions and low manufacturing cost.

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5-Fluorouracil monodispersed chitosan microspheres: Microfluidic chip fabrication with crosslinking, characterization, drug release and anticancer activity

Carbohydrate Polymers ◽

10.1016/j.carbpol.2020.116094 ◽

2020 ◽

Vol 236 ◽

pp. 116094 ◽

Cited By ~ 6

Author(s):

Tianxi He ◽

Wenbin Wang ◽

Benshou Chen ◽

Jiu Wang ◽

Qionglin Liang ◽

...

Keyword(s):

Drug Release ◽

Anticancer Activity ◽

Microfluidic Chip ◽

Chitosan Microspheres ◽

Chip Fabrication

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The Microchannel of Microfluidic Chip Fabrication by Micro-Powder Blasting

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.76-78.367 ◽

2009 ◽

Vol 76-78 ◽

pp. 367-372

Author(s):

Chiung Fang Huang ◽

Yung Kang Shen ◽

Yi Lin ◽

Chi Wei Wu

Keyword(s):

Microfluidic Chip ◽

High Speed ◽

Gas Flow ◽

Erosion Resistance ◽

Processing Parameters ◽

Powder Size ◽

Dimethyl Siloxane ◽

Powder Blasting ◽

Processing Procedure ◽

Chip Fabrication

The process of micro-powder blasting is the high speed gas flow which mixed the micro-particle and gas to impact the brittle substrate by the specialized nozzle. This paper combined various diameters Al2O3 eroding particle with a novel masking technique to fabricate the pattern channels in soda glass with a width to 2000 μm and depth down to 1631 μm. The masking technology for fabricating microchannel is consisted by the combination of two polymers: 1) the elastic and thermal-curable poly-(dimethyl siloxane) (PDMS) for its erosion resistance and 2) the brittle epoxy resin SU-8 for its photosensitivity. This paper discusses the processing procedure by the different processing parameters (micro-powder impact pressure, the distance between nozzle and substrate, micro-powder size, and micro-powder impact time) to find the optimal process. The results show that the micro-powder size is the most important factor for the depth of microchannel of microfluidic chip. The surface roughness of microchannel of microfluidic chip is nearly 5-6μm.

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