scholarly journals A Method for Manufacturing Flexible Microfluidic Chip Based on Soluble Material

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Junyao Wang ◽  
Xingyu Chen ◽  
Huan Liu ◽  
Gongchen Sun ◽  
Yunpeng Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Dissolution Rate ◽  
Microfluidic Chip ◽  
Experimental Studies ◽  
Bonding Process ◽  
Manufacturing Cost ◽  
Processing Conditions ◽  
Microfluidic Chips ◽  
Novel Method ◽  
Soluble Material

In this paper, a novel method for manufacturing flexible microfluidic chips without bonding process is proposed, which combines 3D printing technology and material dissolution technology. The manufacturing process of the microfluidic chip is as follows: a soluble HIPS mold with a preset shape is manufactured by 3D printing and placed in a molten PDMS solution for solidification. Soak in the limonene material to dissolve the mold and form a microchannel in the cured PDMS. Experimental studies have shown that the temperature and concentration of the limonene solution have an important effect on the dissolution rate. A 0.62 cm3 HIPS mold has the fastest dissolution rate at 100°C and 50% concentration. The proposed method provided a new idea for fabricating flexible microfluidic chip. Compared to bonding process, it has the characteristics of not relying on complicated processing conditions and low manufacturing cost.

scholarly journals Microfluidic Temperature Behavior in a Multi-Material 3D Printed Chip

2019 ◽  
Author(s):  
Derek Sanchez ◽  
Greg Nordin ◽  
Troy Munro
Keyword(s):  
3D Printing ◽  
Temperature Control ◽  
Microfluidic Chip ◽  
Iterative Process ◽  
Target Volume ◽  
Temperature Sensing ◽  
Temperature Sensitive ◽  
Microfluidic Chips ◽  
Process Verification ◽  
3D Printed

Abstract As analysis systems shrink in size to microfluidic scales and devices, there is a need to improve temperature control in the microscale for temperature-sensitive processes. Technology that combines accurate temperature measurement and 3D spatial control of the temperature distribution is limited by common 2D layer-based microfluidic fabrication techniques but can be realized with 3D printed microfluidic chips. This work presents an iterative process to create a microfluidic chip using multi-material 3D printing to improve temperature sensing and create an even temperature around a target volume. Through an iterative process, verification is presented of fluorophore viability (specifically CdTe quantum dots) after being secured in place by cured PR48 3D printing resin, thus confirming the possibility of fluorescent thermometry as an accurate non-contact temperature sensing method. Numerical analyses of various geometries of chip design iterations are also presented verifying spatially even heating due to the placement of heating sources in the microfluidic chip. Combining the fluorescent thermometry and improved heating will lead to improved temperature control in microfluidic devices.

A NOVEL METHOD FOR RAPID FABRICATION OF PMMA MICROFLUIDIC CHIP BY LASER CUTTING AND SEALING INTEGRATION

2019 ◽  
Vol 26 (08) ◽  
pp. 1950042 ◽  
Author(s):  
XUEYE CHEN ◽  
TIECHUAN LI ◽  
QI GAO
Keyword(s):  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Laser Cutting ◽  
Cost Effective ◽  
Cover Plate ◽  
Microfluidic Chips ◽  
Pmma Substrate ◽  
Rapid Fabrication ◽  
Novel Method ◽  
Liquid Pools

In this paper, we present a new method that is capable of manufacturing microfluidic chips of polymethyl methacrylate (PMMA) rapidly and cheaply. This technique, which we call Tape adhering-Laser Cutting and Sealing Integration (TLCSI), only utilizes a CO2 laser and a piece of double-sided tape to produce a microfluidic chip in several minutes. It only has three main steps. First, the double-sided tape sticks to the surface of a PMMA substrate. Second, the microchannel should be cut on the surface of the double-sided tape. At last, a PMMA cover plate with liquid pools is pressed onto the surface of the double-sided tape and a CO2 laser is used to cut edges of the chip for sealing the chip. We present a qualified microfluidic chip with regular microchannels and sealing strength of 1.2[Formula: see text]Mpa. Compared with most current fabrication methods, TLCSI is a quick and cost-effective way to produce microfluidic chips of PMMA.

scholarly journals A Novel Method for Precise Guided Hole Fabrication of Dental Implant Surgical Guide Fabricated with 3D Printing Technology

2020 ◽  
Vol 11 (1) ◽  
pp. 49
Author(s):  
Keunbada Son ◽  
Kyu-Bok Lee
Keyword(s):  
3D Printing ◽  
Dental Implant ◽  
Present Report ◽  
Free Software ◽  
3D Printer ◽  
Printing Technology ◽  
Surgical Guide ◽  
3 Dimensional ◽  
3D Printing Technology ◽  
Novel Method

A dental implant surgical guide fabricated by 3-dimensional (3D) printing technology is widely used in clinical practice due to its convenience and fast fabrication. However, the 3D printing technology produces an incorrect guide hole due to the shrinkage of the resin materials, and in order to solve this, the guide hole is adjusted using a trimmer or a metal sleeve is attached to the guide hole. These methods can lead to another inaccuracy. The present method reports a technique to compensate for a decreased guide hole caused by shrinkage that can occur when a computer-guided implant surgical guide is fabricated with a 3D printer. The present report describes a technique to adjust the size of the guide hole using a free software program to identify the optimized guide hole size that is fabricated with the 3D printer.

Study on the Manufacture of Microfluidic Chip with Coated Glass

2012 ◽  
Vol 548 ◽  
pp. 254-257 ◽  
Author(s):  
Yan He ◽  
Bai Ling Huang ◽  
Yong Lai Zhang ◽  
Li Gang Niu
Keyword(s):  
Microfluidic Chip ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Critical Factor ◽  
Wet Etching ◽  
Microfluidic Chips ◽  
Etching Technique ◽  
Chip Quality ◽  
Wet Chemical ◽  
Wet Chemical Etching

In this paper, a simple and facile technique for manufacturing glass-based microfluidic chips was developed. Instead of using expensive dry etching technology, the standard UV lithography and wet chemical etching technique was used to fabricate microchannels on a K9 glass substrate. The fabrication process of microfluidic chip including vacuum evaporation, annealing, lithography, and BHF (HF-NH4F-H2O) wet etching were investigated. Through series experiments, we found that anneal was the critical factor for chip quality. As a representative example, a microfluidic channel with 20 m of depth, and 80 m of width was successfully prepared, and the channel surfaces are quite smooth. These results present a simple, low cost, flexible and easy way to fabricate glass-based microfluidic chips.

Ball Grid Array Thermomechanical Response During Reflow Assembly

1996 ◽  
Vol 118 (4) ◽  
pp. 214-222 ◽  
Author(s):  
T. E. Voth ◽  
T. L. Bergman
Keyword(s):  
Process Model ◽  
Experimental Studies ◽  
Ball Grid Array ◽  
Mechanical Processing ◽  
Processing Conditions ◽  
System Behavior ◽  
Reflow Soldering ◽  
Thermomechanical Response ◽  
Model Predictions ◽  
Representative System

The thermomechanical response of ball-grid array assemblies during reflow soldering is considered here. Experiments are performed to investigate the thermomechanical response of a representative system and the results are used to validate a numerical model of system behavior. The conclusions drawn from the experimental studies are used to guide development of a process model capable of describing more realistic BGA soldering scenarios. Process model predictions illustrate the system’s thermomechanical response to thermal and mechanical processing conditions, as well as component properties. High thermal conductivity assemblies show the greatest sensitivity to mechanical loading conditions.

scholarly journals Experimental studies of the quality of embossed characters of the Braille alphabet

2016 ◽  
Vol 64 (3) ◽  
pp. 607-614
Author(s):  
R. Barczyk ◽  
D. Jasińska-Choromańska
Keyword(s):  
Surface Roughness ◽  
Statistical Analysis ◽  
3D Printing ◽  
Rapid Prototyping ◽  
Experimental Studies ◽  
Printed Text ◽  
Blind Persons ◽  
Blind Individuals

Abstract The paper presents studies pertaining to the quality of embossed characters of the Braille alphabet used, among other applications, for tagging drug labels. The following parameters of embossed inscriptions were measured: height, diameter of the dots and surface roughness (18 samples with various combinations of their values). 48 blind individuals assessed the quality of the printed text. Statistical analysis proved that a text with dots having height of 0.9 millimeter, diameter of 1.6 millimeters and roughness Ra of about 1 micrometer to be the best. The samples had been made using two different methods of rapid prototyping: PolyJet and SLS. 3D printing is increasingly popular and the studies proved the usefulness of these methods for labeling with embossed inscriptions, due to the repeatability, durability and quality they ensure. The assessing group of blind individuals was comprised of 24 persons 14–17 years old and other 24 persons aged over 60 who were not proficient in reading Braille alphabet, This allows to conclude that a text featuring the above values of the parameters will be easy to read for the majority of blind persons.

Tropylium Salt Promoted Hydroboration Reactions: Mechanistic Insights via Experimental and Computational Studies

2021 ◽  
Author(s):  
Nhan Nu Hong Ton ◽  
Binh Khanh Mai ◽  
Thanh Vinh Nguyen
Keyword(s):  
Dft Calculations ◽  
Lewis Acids ◽  
Experimental Studies ◽  
Cross Coupling ◽  
Computational Studies ◽  
Metal Free ◽  
Hydride Abstraction ◽  
Novel Method ◽  
Tropylium Salts

Abstract: Hydroboration reaction of alkynes is one of the most synthetically powerful tools to access organoboron compounds, versatile precursors for cross coupling chemistry. This type of reaction has traditionally been mediated by transition metal or main group catalysts. Herein, we report a novel method using tropylium salts, typically known as organic oxidants and Lewis acids, to efficiently promote the hydroboration reaction of alkynes. A broad range of vinylboranes can be easily accessed via this metal-free protocol. Similar hydroboration reactions of alkenes and epoxides can also be efficiently catalyzed by the same tropylium catalysts. Experimental studies and DFT calculations suggested that the reaction follows an uncommon mechanistic paradigm, which is triggered by a hydride abstraction of pinacolborane with tropylium ion. This is followed by a series of <i>in situ</i> counterion-activated substituent exchanges to generate boron intermediates that promote the hydroboration reaction.

A multi-scale E-Jet 3D printing regulated by structured multi-physics field

2021 ◽  
Author(s):  
Kai Li ◽  
Yihui Zhao ◽  
Maiqi Liu ◽  
Xiaoying Wang ◽  
Fangyuan Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Aspect Ratio ◽  
Process Parameters ◽  
High Aspect Ratio ◽  
Thermal Field ◽  
Structural Features ◽  
Microfluidic Chips ◽  
Multi Scale ◽  
Fluid Field

Abstract Micro/nano scale structure as important functional part have been widely used in wearable flexible sensors, gas sensors, biological tissue engineering, microfluidic chips super capacitors and so on. Here a multi-scale electrohydrodynamic jet (E-Jet) 3D printing approach regulated by structured multi-physics fields was demonstrated to generate 800 nm scale 2D geometries and high aspect ratio 3D structures. The simulation model of jetting process under resultant effect of top fluid field, middle electric field and bottom thermal field was established. And the physical mechanism and scale law of jet formation were studied. The effects of thermal field temperature, applied voltage and flow rate on the jet behaviors were studied; and the range of process parameters of stable jet was obtained. The regulation of printing parameters was used to manufacture the high resolution gradient graphics and the high aspect ratio structure with tight interlayer bonding. The structural features could be flexibly adjusted by reasonably matching the process parameters. Finally, PCL/PVP composite scaffolds with cell-scale fiber and ordered fiber spacing were printed. The proposed E-Jet printing method provides an alternative approach for the application of biopolymer materials in tissue engineering.

Synergistic bonding process of solvent and tendon for PC-based microfluidic chips

2015 ◽  
Vol 23 (3) ◽  
pp. 708-713 ◽  
Author(s):  
范建华 FAN Jian-hua ◽  
邓永波 DENG Yong-bo ◽  
宣明 XUAN Ming ◽  
刘永顺 LIU Yong-shun ◽  
武俊峰 WU Jun-feng ◽  
...  
Keyword(s):  
Bonding Process ◽  
Microfluidic Chips
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