Phthalocyanine-cRGD conjugate: synthesis, photophysical properties and in vitro biological activity for targeting photodynamic therapy

2016 ◽  
Vol 14 (10) ◽  
pp. 2985-2992 ◽  
Author(s):  
Liqiang Luan ◽  
Wenjuan Fang ◽  
Wei Liu ◽  
Minggang Tian ◽  
Yuxing Ni ◽  
...  
Keyword(s):  
Biological Activity ◽  
Photodynamic Therapy ◽  
Cross Section ◽  
Cellular Uptake ◽  
Photophysical Properties ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Two Photon

Phthalocyanine-RGD conjugate was synthesized and examined for its two-photon absorption cross section (TPACS), cellular uptake, and photocytotoxicity.

Syntheses and properties of acetylene-linked bis- and trisporphyrins toward two-photon photodynamic therapy

2007 ◽  
Vol 11 (06) ◽  
pp. 406-417 ◽  
Author(s):  
Yusuke Inaba ◽  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Cross Section ◽  
Sodium Salt ◽  
Absorption Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Photon Irradiation ◽  
Two Photon

Acetylene-bridged bisporphyrins and trisporphyrins having branched bulky bis(carboxylethyl)methyl meso-substituents were synthesized. These compounds showed large effective two-photon absorption cross-section values at 890 nm measured by using a nanosecond Z-scan method. Sodium salt of hydrolyzed trisporphyrins showed broad and red-shifted Q-bands over 900 nm. Two-photon absorption cross-section values of water-soluble dimers in water were similar to, or slightly larger than, those of ester forms evaluated in toluene. Furthermore, the generation of singlet oxygen upon one-photon irradiation for dimers in water was confirmed.

scholarly journals Rational design of small indolic squaraine dyes with large two-photon absorption cross section

2015 ◽  
Vol 6 (1) ◽  
pp. 761-769 ◽  
Author(s):  
Chun-Lin Sun ◽  
Qing Liao ◽  
Ting Li ◽  
Jun Li ◽  
Jian-Qiao Jiang ◽  
...  
Keyword(s):  
Cross Section ◽  
Rational Design ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Squaraine Dyes ◽  
Two Photon ◽  
Bio Imaging

Assisted by theoretical analysis, we designed a small indolic squaraine with δ > 8000 GM at 780 nm, which is ideal for both in vitro and in vivo bio-imaging applications.

Comparative photophysics of sapphyrin derivatives: effects of confused and fused pyrrole rings

2011 ◽  
Vol 15 (09n10) ◽  
pp. 858-864 ◽  
Author(s):  
Jong Min Lim ◽  
Iti Gupta ◽  
Hiroyuki Furuta ◽  
Dongho Kim
Keyword(s):  
Excited State ◽  
Cross Section ◽  
Absorption Cross Section ◽  
Photophysical Properties ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Time Resolved ◽  
Nonradiative Decay ◽  
Two Photon Absorption ◽  
Two Photon

We have investigated the photophysical properties of [22] π-conjugated pentapyrrolic systems, sapphyrin, N-confused and N-fused sapphyrins, with a particular focus on the effects of confused and fused pyrrole rings on their electronic structures using steady-state and time-resolved spectroscopic methods, two-photon absorption cross-section (σ(2)) measurements and quantum mechanical calculations. The absorption spectra of N-confused and N-fused sapphyrins exhibit relatively red-shifted features compared to sapphyrin. In parallel with these spectral features, the reduced HOMO–LUMO gaps were observed in going from sapphyrin to N-fused sapphyrin. In the analysis of the anisotropy of the induced current density (AICD), N-confused and N-fused sapphyrins show that extra π-electrons in confused and fused pyrrole rings contribute to the extension of their π-conjugation pathways. Slightly larger twophoton absorption cross-section values of N-confused and N-fused sapphyrins (3250 and 3900 GM) than that of sapphyrin (2900 GM) also reflect an enhanced π-conjugation effect due to bicyclic and endocyclic extensions in π-conjugation pathways, respectively. The excited singlet and triplet state lifetimes of N-confused sapphyrin were determined to be 60 ps and 1 μs, respectively, due to conformational change and acceleration of nonradiative decay processes, being in a sharp contrast with those of sapphyrin (2.4 ns and 13 μs, respectively). In the case of N-fused sapphyrin, very short singlet excited-state lifetime of 5 ps was detected probably due to the excited-state NH-tautomerization process which enhances nonradiative decay processes.

A small-molecule with a large two-photon absorption cross-section serves as a membrane-permeable ribonucleic acid (RNA) probe for live cell imaging

2018 ◽  
Vol 42 (17) ◽  
pp. 14325-14331 ◽  
Author(s):  
Ruiqing Feng ◽  
Longlong Li ◽  
Bing Li ◽  
Jinhui Li ◽  
Dan Peng ◽  
...  
Keyword(s):  
Cross Section ◽  
Cross Sections ◽  
Live Cell Imaging ◽  
Plasma Membranes ◽  
Cell Imaging ◽  
Photon Absorption ◽  
Absorption Cross ◽  
High Permeability ◽  
Two Photon Absorption ◽  
Two Photon

DMI could light up the RNA of the nucleus and the cytoplasm in living systems, which not only exhibits larger two-photon absorption cross-sections (981 GM), but also displays high-permeability to plasma membranes of vigorous cells.

scholarly journals Ultrafast processes triggered by one- and two-photon excitation of a photochromic and luminescent hydrazone

2019 ◽  
Vol 15 ◽  
pp. 2438-2446 ◽  
Author(s):  
Alessandro Iagatti ◽  
Baihao Shao ◽  
Alberto Credi ◽  
Barbara Ventura ◽  
Ivan Aprahamian ◽  
...  
Keyword(s):  
Excited State ◽  
Cross Section ◽  
Absorption Cross Section ◽  
Transient Absorption ◽  
Solvent Polarity ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Time Resolved ◽  
Two Photon Absorption ◽  
Two Photon

In this work we apply a combination of steady state and time resolved luminescence and absorption spectroscopies to investigate the excited-state dynamics of a recently developed molecular photoswitch, belonging to the hydrazone family. The outstanding properties of this molecule, involving fluorescence toggling, bistability, high isomerization quantum yield and non-negligible two-photon absorption cross section, make it very promising for numerous applications. Here we show that the light induced Z/E isomerization occurs on a fast <1 ps timescale in both toluene and acetonitrile, while the excited state lifetime of the Z-form depends on solvent polarity, suggesting a partial charge transfer nature of its low lying excited state. Time-resolved luminescence measurements evidence the presence of a main emission component in the 500–520 nm spectral range, attributed to the Z-isomer, and a very short living blue-shifted emission, attributed to the E-isomer. Finally, transient absorption measurements performed upon far-red excitation are employed as an alternative method to determine the two-photon absorption cross-section of the molecule.

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