Gold nanoparticles as potent anticancer agent: green synthesis, characterization, and in vitro study

In this study, green synthesis of gold nanoparticles were success fully synthesised by using Adina cordifolia plant bark aqueous extract which provides eco-friendly process, an environmentally benign, easy and proficient way for the synthesis of gold nanoparticles. The smaller size of gold nanoparticles have research on various dieses are very important. The green synthesized gold nanoparticles were characterized by UV-Visible spectroscopy, FT-IR, XRD, SEM, TEM and their antimicrobial activity was investigated. From UV-Visible spectrophotometer result was confirmed the formation of gold nanoparticles by color changed to ruby red color from pale yellow color indicates the reduction of Au3+ ions to Auo. The antibacterial activity for the synthesized gold nanoparticles was confirmed by the antibacterial activity experiment against Bacillus subtilis and Escherichia coli by agar well method. The synthesized AuNPs was performed anticancer activity against MCF-7 breast cancer cell line. Compared to Adriamycin, Positive Control Compound AuNPs exhibited potent anticancer activity with the IC50. The green synthesized gold nanoparticles proved to be potential candidates for medical application antimicrobial and anticancer activity is highly essential.

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Synthesis, characterization and in vitro assessment of colloidal gold nanoparticles of Gemcitabine with natural polysaccharides for treatment of breast cancer

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2020.101565 ◽

2020 ◽

Vol 56 ◽

pp. 101565 ◽

Cited By ~ 6

Author(s):

Laxmi Devi ◽

Rishikesh Gupta ◽

Sanjay Kumar Jain ◽

Sima Singh ◽

Prashant Kesharwani

Keyword(s):

Breast Cancer ◽

Gold Nanoparticles ◽

Colloidal Gold ◽

Colloidal Gold Nanoparticles ◽

In Vitro Assessment

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Antimalarial silver and gold nanoparticles: Green synthesis, characterization and in vitro study

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2017.04.032 ◽

2017 ◽

Vol 91 ◽

pp. 567-580 ◽

Cited By ~ 33

Author(s):

Partha P. Dutta ◽

Manobjyoti Bordoloi ◽

Kabita Gogoi ◽

Sonali Roy ◽

Bardwi Narzary ◽

...

Keyword(s):

Gold Nanoparticles ◽

Green Synthesis ◽

In Vitro Study ◽

Vitro Study ◽

Silver And Gold Nanoparticles

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Green synthesis of Nerium oleander-conjugated gold nanoparticles and study of its in vitro anticancer activity on MCF-7 cell lines and catalytic activity

Nano Convergence ◽

10.1186/s40580-018-0142-5 ◽

2018 ◽

Vol 5 (1) ◽

Cited By ~ 26

Author(s):

Abir Chandan Barai ◽

Koushik Paul ◽

Aditi Dey ◽

Subhankar Manna ◽

Somenath Roy ◽

...

Keyword(s):

Gold Nanoparticles ◽

Catalytic Activity ◽

Green Synthesis ◽

Anticancer Activity ◽

Cell Lines ◽

Nerium Oleander ◽

Mcf 7

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Vitamin D as potential therapeutic anticancer agent

Journal of Cancer Science and Therapeutics ◽

10.36879/jcst.19.000106 ◽

2018 ◽

pp. 1-3

Keyword(s):

Vitamin D ◽

Anticancer Activity ◽

Anticancer Agent ◽

Antitumor Agents ◽

Metastatic Potential ◽

Anticancer Properties ◽

Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

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