Enzyme-sensitive cytotoxic peptide–dendrimer conjugates enhance cell apoptosis and deep tumor penetration

2018 ◽  
Vol 6 (3) ◽  
pp. 604-613 ◽  
Author(s):  
Fu-Hua Liu ◽  
Chun-Yuan Hou ◽  
Di Zhang ◽  
Wen-Jing Zhao ◽  
Yong Cong ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Pamam Dendrimers ◽  
Cellular Internalization ◽  
Tumor Penetration ◽  
Dendrimer Conjugates ◽  
Cytotoxic Peptide ◽  
Peptide Dendrimer

Cytotoxic peptide conjugated PAMAM dendrimers with MMP2-sensitive PEG for efficient tumor penetration, cellular internalization and mitochondria disruption.

scholarly journals Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides

2010 ◽  
Vol 21 (10) ◽  
pp. 1902-1911 ◽  
Author(s):  
Amer F. Saleh ◽  
Andrey Arzumanov ◽  
Rachida Abes ◽  
David Owen ◽  
Bernard Lebleu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Dendrimer Conjugates ◽  
Peptide Dendrimer

Surface Modification of PAMAM Dendrimers Modulates the Mechanism of Cellular Internalization

2009 ◽  
Vol 20 (4) ◽  
pp. 693-701 ◽  
Author(s):  
Angkana Saovapakhiran ◽  
Antony D’Emanuele ◽  
David Attwood ◽  
Jeffrey Penny
Keyword(s):  
Surface Modification ◽  
Pamam Dendrimers ◽  
Cellular Internalization

Anticancer Activity of Resorcinarene-PAMAM-Dendrimer Conjugates of Flutamide

2018 ◽  
Vol 18 (7) ◽  
pp. 993-1000 ◽  
Author(s):  
Luis D. Pedro-Hernández ◽  
Elena Martínez-Klimova ◽  
Mark E. Martínez-Klimov ◽  
Sandra Cortez-Maya ◽  
Ana C. Vargas-Medina ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
High Drug ◽  
One Step ◽  
Dendritic Branches ◽  
Dendrimer Conjugates

Methods: The synthesis of conjugates of flutamide with resorcinarene-PAMAM-dendrimers as well as alkyl and ethyl phenyl chains in the lower part of the macrocycle as a nucleus and diethylenetriamines in the dendritic branches gives the opportunity to obtain conjugates in one step of synthesis with 16 and 64 flutamide moieties in the structure. Results: The in vitro anticancer studies showed that the conjugates of flutamide are more active than the free flutamide and the flutamide derivatives, thus diminishing the amount of flutamide used. The resorcinarenedendrimer- flutamide conjugates with a high drug payload improve the activity of the drug. Conclusion: This is important in delivering a sufficient amount of flutamide and suggests that the dendrimer facilitates more of the drug being introduced into cells. It was also observed that the new conjugates are less toxic than the anti-androgens.

scholarly journals Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery

2017 ◽  
Vol 102 ◽  
pp. 237-249 ◽  
Author(s):  
Aswathi R Hegde ◽  
Prarthana V Rewatkar ◽  
Jyothsna Manikkath ◽  
Karnaker Tupally ◽  
Harendra S Parekh ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Passive Diffusion ◽  
Skin Delivery ◽  
Dendrimer Conjugates ◽  
Peptide Dendrimer

Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

2020 ◽  
Vol 49 (33) ◽  
pp. 11583-11590 ◽  
Author(s):  
Zheng-Yin Pan ◽  
Dai-Hong Cai ◽  
Liang He
Keyword(s):  
Photodynamic Therapy ◽  
Cell Apoptosis ◽  
Lysosomal Dysfunction ◽  
Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

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