scholarly journals Real-time dynamic SERS detection of galectin using glycan-decorated gold nanoparticles

2017 ◽  
Vol 205 ◽  
pp. 363-375 ◽  
Author(s):  
Judith Langer ◽  
Isabel García ◽  
Luis M. Liz-Marzán
Keyword(s):  
Gold Nanoparticles ◽  
Fast Time ◽  
Specific Detection ◽  
Natural Conditions ◽  
Au Nps ◽  
Time Dynamic ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Enhanced Raman Scattering

We present the application of surface-enhanced Raman scattering (SERS) spectroscopy for the fast, sensitive and highly specific detection of the galectin-9 (Gal-9) protein in binding buffer (mimicking natural conditions). The method involves the use of specifically designed nanotags comprising glycan-decorated gold nanoparticles encoded with 4-mercaptobenzoic acid. At fast time scales Gal-9 can be detected down to a concentration of 1.2 nM by monitoring the SERS signal of the reporter, driven by aggregation of the functionalized Au NPs tags, induced by Gal-9 recognition. We additionally demonstrate that the sensitivity and concentration working range of the sensor can be tuned via control of aggregation dynamics and cluster size distribution.

scholarly journals The highly sensitive determination of serotonin by using gold nanoparticles (Au NPs) with a localized surface plasmon resonance (LSPR) absorption wavelength in the visible region

RSC Advances ◽  
2020 ◽  
Vol 10 (51) ◽  
pp. 30858-30869
Author(s):  
Phuong Que Tran Do ◽  
Vu Thi Huong ◽  
Nguyen Tran Truc Phuong ◽  
Thi-Hiep Nguyen ◽  
Hanh Kieu Thi Ta ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Visible Region ◽  
Localized Surface Plasmon ◽  
Au Nps ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Sensitive Determination

The development of improved methods for the synthesis of monodisperse gold nanoparticles (Au NPs) is of high priority because they can be used as substrates for surface-enhanced Raman scattering (SERS) applications relating to biological lipids.

Surface Enhanced Raman Scattering of Defective TiO2 with Gold Au NPs by Green Method

2021 ◽  
Vol 19 (7) ◽  
pp. 25-34
Author(s):  
Alaa A. Shanef ◽  
Waleed Hameed Abed ◽  
Ahmed R. Mathloom
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
Gas Sensors ◽  
Au Nanoparticles ◽  
Tio2 Films ◽  
Green Method ◽  
Au Nps ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

This works strong the embossing as regards riches (Au) nanoparticles (NPs) regarding attenuate TiO2 films. Au (Au-TiO2) patterned flabby film TiO2. The morphology, cleanly structure, issue administration then optical homes concerning the films hold been studied. Gold nanoparticles (Au-NPs) are synthesized along the useful resource on lowering hydrated gold steel ions of touch together along aqueous sow dermis extract. The alternate among the elevation or assignment about Au NPs elevated the reply above the ethanol gas sensors. The organized Au-TiO2 was once tested, of assessment together with allusion TiO2 membranes, such then ethanol sensors at 250-350 ° C at a fuel attention of 50-1000 ppm. In addition, the SERS deep concerning the excised Au/ TiO2 emaciated movie is about iii cases that above the deposited Au/ TiO2 gaunt film. The results proven in imitation of so much aggregation Au-coated TiO2 at 6 s spray epoch gave the beneficial file on 514 at 350 ° C deed useless heat since 1000 ppm fuel concentration.

scholarly journals Study on Surface-Enhanced Raman Scattering Substrate Based on Titanium Oxide Nanorods Coated with Gold Nanoparticles

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaodong Wang ◽  
Xiulan Cheng ◽  
Xufeng Yu ◽  
Xueling Quan
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
Titanium Oxide ◽  
Surface Enhanced Raman Scattering ◽  
Au Nps ◽  
Oxide Nanorods ◽  
Relative Standard ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A 3D surface-enhanced Raman scattering (SERS) substrate based on titanium oxide nanorods (TiOx-NRs) coated with gold nanoparticles (Au-NPs) was fabricated by a simple hydrothermal, no-template process. The nanostructure of TiOx-NRs influenced by the concentrations of hydrochloric (HCl) acid and sodium chloride (NaCl) was studied in detail. The substrate showed the strongest Raman enhancement, when the diameters of Au-NPs were around 40 nm and the gaps of Au-NPs were in the range of 5 nm to 10 nm. The surface electric field of our substrate was examined by finite-different time-domain (FDTD) solutions. Rhodamine 6G (R6G) was chosen as the probe molecule to study the SERS performance of the substrates. The Raman signal of 10−10 M R6G was detected clearly by the substrate with the enhancement factor of 2.64 × 108. All relative standard deviation (RSD) values of the major peaks for R6G were within the scope of 10.4% to 16.7%. The substrate could work efficiently even after immersed in water for one month.

scholarly journals Bromide-Assisted Anisotropic Growth of Gold Nanoparticles as Substrates for Surface-Enhanced Raman Scattering

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Melissa A. Kerr ◽  
Fei Yan
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
Chemical Properties ◽  
Surface Enhanced Raman Scattering ◽  
Synthetic Methods ◽  
Au Nps ◽  
Vis Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

We report herein a one-step synthesis of gold nanoparticles (Au NPs) of various shapes such as triangles, hexagons, and semispheres, using 5-hydroxyindoleacetic acid (5-HIAA) as the reducing agent in the presence of potassium bromide (KBr). Anisotropic Au NPs have received ever-increasing attention in various areas of research due to their unique physical and chemical properties. Numerous synthetic methods involving either top-down or bottom-up approaches have been developed to synthesize Au NPs with deliberately varied shapes, sizes, and configurations; however, the production of templateless, seedless, and surfactant-free singular-shaped anisotropic Au NPs remains a significant challenge. The concentrations of hydrogen tetrachloroaurate (HAuCl4), 5-HIAA, and KBr, as well as the reaction temperature, were found to influence the resulting product morphology. A detailed characterization of the resulting Au NPs was performed using ultraviolet-visible (UV-Vis) spectroscopy, scanning electron microscopy (SEM), and Raman spectroscopy. The as-prepared Au NPs exhibited excellent surface-enhanced Raman scattering (SERS) properties, which make them very attractive for the development of SERS-based chemical and biological sensors.

Gold Nanoparticles - An Enhanced DNA Sensing Tools Using Surface Enhance Raman Scattering

2015 ◽  
Vol 1109 ◽  
pp. 439-443
Author(s):  
Md. Mahfujur Rahman ◽  
Md Eaqub Ali ◽  
Sharifah Bee Abd Hamid
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
Dna Hybridization ◽  
Atomic Scale ◽  
Dna Sensing ◽  
Au Nps ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Species Authentication

Molecular recognition of specific DNA target is crucial for species authentication, drug discovery, forensic investigation and biodiagnostics. Development of nanoparticles at atomic scale and molecular level offers remarkable biocompatibility in the detection of DNA hybridization. Oligo-functionalized nanoparticles with controlled sizes and shapes have come forward with advantages over the previously documented DNA detection assays. Nanomaterials facilitate signal transduction and synergism in biomolecular interaction, promoting both conventional and newly developed DNA identification platforms. Tailoring of DNA sensing tools with gold nanoparticles (Au NPs) enhances the Surface Enhanced Raman Scattering (SERS) signal, allowing target detection with molecular precision. Here we briefly reviewed the recent AuNPs based SERS-platforms for the specific, sensitive and reliable detection of DNA targets for species authentication in foods and feeds.

A sensitive SERS assay for detecting proteins and nucleic acids using a triple-helix molecular switch for cascade signal amplification

2014 ◽  
Vol 50 (66) ◽  
pp. 9409-9412 ◽  
Author(s):  
Sujuan Ye ◽  
Yanying Wu ◽  
Wen Zhang ◽  
Na Li ◽  
Bo Tang
Keyword(s):  
Nucleic Acids ◽  
Signal Amplification ◽  
Triple Helix ◽  
Detection System ◽  
Molecular Switch ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Multiple Cycle ◽  
Enhanced Raman Scattering

A sensitive surface-enhanced Raman scattering (SERS) detection system is developed for proteins and nucleic acids based on a triple-helix molecular switch for multiple cycle signal amplification.

SERS-active metal–organic frameworks with embedded gold nanoparticles

The Analyst ◽  
2017 ◽  
Vol 142 (14) ◽  
pp. 2640-2647 ◽  
Author(s):  
Xiaolin Cao ◽  
Sihui Hong ◽  
Zejun Jiang ◽  
Yongxin She ◽  
Shanshan Wang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
Metal Organic Frameworks ◽  
Surface Enhanced Raman Scattering ◽  
Active Metal ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Metal Organic ◽  
Enhanced Raman Scattering

Surface-enhanced Raman scattering (SERS) has been widely used in the detection of targets and strongly depends on the interaction and the distance between the targets and nanoparticles.

scholarly journals Improving SERS Detection of Bacillus thuringiensis Using Silver Nanoparticles Reduced with Hydroxylamine and with Citrate Capped Borohydride

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Hilsamar Félix-Rivera ◽  
Roxannie González ◽  
Gabriela Del Mar Rodríguez ◽  
Oliva M. Primera-Pedrozo ◽  
Carlos Ríos-Velázquez ◽  
...  
Keyword(s):  
Bacillus Thuringiensis ◽  
Surface Charge ◽  
Near Field ◽  
Medical Diagnostics ◽  
Biological Warfare Agents ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Warfare Agents ◽  
Enhanced Raman Scattering

The development of techniques that could be useful in fields other than biological warfare agents countermeasures such as medical diagnostics, industrial microbiology, and environmental applications have become a very important subject of research. Raman spectroscopy can be used in near field or at long distances from the sample to obtain fingerprinting information of chemical composition of microorganisms. In this research, biochemical components of the cell wall and endospores of Bacillus thuringiensis (Bt) were identified by surface-enhanced Raman scattering (SERS) spectroscopy using silver (Ag) nanoparticles (NPs) reduced by hydroxylamine and borohydride capped with sodium citrate. Activation of “hot spots”, aggregation and surface charge modification of the NPs, was studied and optimized to obtain signal enhancements from Bt by SERS. Slight aggregation of the NPs as well as surface charge modification to a more acidic ambient was induced using small-size borohydride-reduced NPs in the form of metallic suspensions aimed at increasing the Ag NP-Bt interactions. Hydroxylamine-reduced NPs required slight aggregation and no pH modifications in order to obtain high spectral quality results in bringing out SERS signatures of Bt.

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