The role of water molecules in phototransduction of retinal proteins and G protein-coupled receptors

2018 ◽  
Vol 207 ◽  
pp. 27-37 ◽  
Author(s):  
Elena Lesca ◽  
Valérie Panneels ◽  
Gebhard F. X. Schertler
Keyword(s):  
G Protein ◽  
Critical Role ◽  
G Protein Coupled Receptors ◽  
Water Molecules ◽  
Important Class ◽  
Retinal Proteins ◽  
G Protein Coupled

Water molecules play a critical role during activation of GPCRs, one of the most important class of signalling proteins.

scholarly journals The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1228
Author(s):  
Tomasz Boczek ◽  
Joanna Mackiewicz ◽  
Marta Sobolczyk ◽  
Julia Wawrzyniak ◽  
Malwina Lisek ◽  
...  
Keyword(s):  
G Protein ◽  
Psychiatric Illness ◽  
Antipsychotic Drugs ◽  
Molecular Mechanisms ◽  
Critical Role ◽  
G Protein Coupled Receptors ◽  
Disease Development ◽  
Complex Picture ◽  
G Protein Coupled

Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G protein-coupled receptors (GPCRs) play a critical role in disease development, progression, and treatment. This pivotal role is further highlighted by the fact that GPCRs are the most common targets for antipsychotic drugs. The GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca2+ mobilization. Dysfunctions of the neurotransmitter systems involving the action of GPCRs in the frontal and limbic-related regions are likely to underly the complex picture that includes the whole spectrum of positive and negative schizophrenia symptoms. Therefore, the progress in our understanding of GPCRs function in the control of brain cognitive functions is expected to open new avenues for selective drug development. In this paper, we review and synthesize the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology.

The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors

ChemInform ◽  
2007 ◽  
Vol 38 (14) ◽  
Author(s):  
Leonardo Pardo ◽  
Xavier Deupi ◽  
Nicole Doelker ◽  
Maria Luz Lopez-Rodriguez ◽  
Mercedes Campillo
Keyword(s):  
G Protein ◽  
Structure And Function ◽  
G Protein Coupled Receptors ◽  
Water Molecules ◽  
Internal Water ◽  
And Function ◽  
G Protein Coupled

The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors

ChemBioChem ◽  
2007 ◽  
Vol 8 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Leonardo Pardo ◽  
Xavier Deupi ◽  
Nicole Dölker ◽  
María Luz López-Rodríguez ◽  
Mercedes Campillo
Keyword(s):  
G Protein ◽  
Structure And Function ◽  
G Protein Coupled Receptors ◽  
Water Molecules ◽  
Internal Water ◽  
And Function ◽  
G Protein Coupled

scholarly journals The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension

2018 ◽  
Vol 5 ◽  
Author(s):  
Gayathri Viswanathan ◽  
Argen Mamazhakypov ◽  
Ralph T. Schermuly ◽  
Sudarshan Rajagopal
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
The Right ◽  
G Protein Coupled

scholarly journals The role of membrane curvature elastic stress for function of rhodopsin-like G protein-coupled receptors

Biochimie ◽  
2014 ◽  
Vol 107 ◽  
pp. 28-32 ◽  
Author(s):  
Olivier Soubias ◽  
Walter E. Teague ◽  
Kirk G. Hines ◽  
Klaus Gawrisch
Keyword(s):  
G Protein ◽  
Elastic Stress ◽  
Membrane Curvature ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Atypical Chemokine Receptors in Cardiovascular Disease

2019 ◽  
Vol 119 (04) ◽  
pp. 534-541 ◽  
Author(s):  
Selin Gencer ◽  
Emiel van der Vorst ◽  
Maria Aslani ◽  
Christian Weber ◽  
Yvonne Döring ◽  
...  
Keyword(s):  
G Protein ◽  
Chemokine Receptors ◽  
Cellular Response ◽  
Current Knowledge ◽  
G Protein Coupled Receptors ◽  
Signalling Pathways ◽  
Atherosclerosis Development ◽  
G Protein Coupled ◽  
Precise Role

AbstractInflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a crucial role in the pathophysiology of atherosclerosis. Chemokines classically mediate their effects by binding to G-protein-coupled receptors called chemokine receptors. In addition, chemokines can also bind to atypical chemokine receptors (ACKRs). ACKRs fail to induce G-protein-dependent signalling pathways and thus subsequent cellular response, but instead are able to internalize, scavenge or transport chemokines. In this review, we will give an overview of the current knowledge about the involvement of ACKR1–4 in CVDs and especially in atherosclerosis development. In the recent years, several studies have highlighted the importance of ACKRs in CVDs, although there are still several controversies and unexplored aspects that have to be further elucidated. A better understanding of the precise role of these atypical receptors may pave the way towards novel and improved therapeutic strategies.

The Role of MC1R in Speciation & Phylogeny

2013 ◽  
Vol 75 (9) ◽  
pp. 670-676 ◽  
Author(s):  
Susan Offner
Keyword(s):  
G Protein ◽  
Point Mutation ◽  
Solomon Island ◽  
G Protein Coupled Receptors ◽  
Ancestral Population ◽  
Mc1r Gene ◽  
The Many ◽  
Evolutionary Consequences ◽  
G Protein Coupled

A point mutation in the MC1R gene, a G-protein-coupled receptor, has been found that could have led to the formation of two subspecies of Solomon Island flycatcher from a single ancestral population. I discuss the many roles that G-protein-coupled receptors play in vertebrate physiology and how one particular point mutation can have enormous evolutionary consequences.

New thoughts on the role of the βγ subunit in G protein signal transduction

2000 ◽  
Vol 78 (5) ◽  
pp. 537-550 ◽  
Author(s):  
Barbara Vanderbeld ◽  
Gregory M Kelly
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
Limited Information ◽  
Α Subunit ◽  
Downstream Effectors ◽  
Receptor Signal ◽  
G Protein Coupled

Heterotrimeric G proteins are involved in numerous biological processes, where they mediate signal transduction from agonist-bound G-protein-coupled receptors to a variety of intracellular effector molecules and ion channels. G proteins consist of two signaling moieties: a GTP-bound α subunit and a βγ heterodimer. The βγ dimer, recently credited as a significant modulator of G-protein-mediated cellular responses, is postulated to be a major determinant of signaling fidelity between G-protein-coupled receptors and downstream effectors. In this review we have focused on the role of βγ signaling and have included examples to demonstrate the heterogeneity in the heterodimer composition and its implications in signaling fidelity. We also present an overview of some of the effectors regulated by βγ and draw attention to the fact that, although G proteins and their associated receptors play an instrumental role in development, there is rather limited information on βγ signaling in embryogenesis.Key words: G protein, βγ subunit, G-protein-coupled receptor, signal transduction, adenylyl cyclase.

scholarly journals Interactions between Two Different G Protein-Coupled Receptors in Reproductive Hormone-Producing Cells: The Role of PACAP and Its Receptor PAC1R

2016 ◽  
Vol 17 (10) ◽  
pp. 1635 ◽  
Author(s):  
Haruhiko Kanasaki ◽  
Aki Oride ◽  
Tomomi Hara ◽  
Tselmeg Mijiddorj ◽  
Unurjargal Sukhbaatar ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Reproductive Hormone ◽  
G Protein Coupled
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