Complex effect of zinc oxide nanoparticles on cadmium chloride-induced hepatotoxicity in mice: protective role of metallothionein

Metallomics ◽  
2017 ◽  
Vol 9 (6) ◽  
pp. 706-714 ◽  
Author(s):  
Shang Gao ◽  
Xue Wang ◽  
Shasha Wang ◽  
Shanshan Zhu ◽  
Rui Rong ◽  
...  
Life Sciences ◽  
2020 ◽  
Vol 262 ◽  
pp. 118503
Author(s):  
Lamiaa A.A. Barakat ◽  
Nashwa Barakat ◽  
Mahmoud M. Zakaria ◽  
Salma M. Khirallah

2017 ◽  
Vol 12 (1) ◽  
pp. 30-39
Author(s):  
Mona M. Lotfy ◽  
Ibrahim A. Ibrahim ◽  
Sherif Y. Saleh ◽  
Marwa Elbeltagy ◽  
Haytham A. Ali

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Aaser M. Abdelazim ◽  
Islam M. Saadeldin ◽  
Ayman Abdel-Aziz Swelum ◽  
Mohamed M. Afifi ◽  
Ali Alkaladi

The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; the 2nd and 3rd groups were exposed to 1 and 2 mg/L of ZnONPs, respectively; and the 4th and 5th group were exposed to 1 and 2 mg/L of ZnONPs and treated with a (500 mg/kg diet) mixture of vitamin C and E mixture (250 mg/kg diet of each). Muscles were collected on the 7th and 15th day of treatments. Muscle malondialdehyde, reduced glutathione levels, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GR), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activities were measured after treatments. Relative quantification of SOD, CAT, GR, GPx, and GST mRNA transcripts was detected in the muscles. Results showed that MDA and GSH concentration; SOD, CAT, GR, GPx, and GST activities; and mRNA expression were significantly decreased in groups exposed to ZnONPs. Vitamins C and E significantly ameliorated the toxic effects of ZnONPs. In conclusion, vitamins C and E have the ability to ameliorate ZnONP oxidative stress toxicity in Nile tilapia.


2019 ◽  
Vol 87 (September) ◽  
pp. 3469-3483
Author(s):  
AMIRA F. A. AHMED, M.Sc.; IBRAHIM A. IBRAHIM, M.D. ◽  
HANAN E.L. MOKHTAR, M.D.; MANAL M. MORSY, M.D.

Author(s):  
Amer M. Abdelaziz ◽  
Sawsan Dacrory ◽  
Amr H. Hashem ◽  
Mohamed S. Attia ◽  
Mohamed Hasanin ◽  
...  

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