scholarly journals Effect of Zinc Oxide Nanoparticles on the Structure of Testis of Adult Albino Rats and the Possible Protective Role of Naringenin

2019 ◽  
Vol 87 (September) ◽  
pp. 3469-3483
Author(s):  
AMIRA F. A. AHMED, M.Sc.; IBRAHIM A. IBRAHIM, M.D. ◽  
HANAN E.L. MOKHTAR, M.D.; MANAL M. MORSY, M.D.
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Protective Role ◽  
Albino Rats ◽  
Oxide Nanoparticles

scholarly journals Changes in Rats’ Liver Structure Induced by Zinc Oxide Nanoparticles and the Possible Protective Role of Vitamin E

2018 ◽  
Vol 1 (3) ◽  
pp. 1-16 ◽  
Author(s):  
Abdelmonem A. Hegazy ◽  
Marwa M. Ahmed ◽  
Mohammed A. Shehata ◽  
Marwa M Abdelfattah
Keyword(s):  
Zinc Oxide ◽  
Vitamin E ◽  
Zinc Oxide Nanoparticles ◽  
Treated Group ◽  
Protective Role ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
Oral Ingestion ◽  
Group 3

Background: Oral ingestion of zinc oxide nanoparticles (ZnONPs) may lead to serious liver injury. Vitamin E (VE) is an important antioxidant factor that can reduce such damage. Aim: This study aimed to evaluate the possible changes that could take place in the liver of adult male albino rats after oral ingestion of ZnONPs and elucidate the potential protective role of VE against such damage. Material and Methods: Forty eight male albino rats were divided into four groups of 12 animals each. Group (1) served as control group and received normal saline. Group (2) “VE-treated” received 100 mg/kg/day of VE dissolved in normal saline by oral gavage for 21 days. Group (3) “ZnONPs-treated” received a daily dose of ZnONPs dispersed in the fresh sterilized physiological saline solution 1mg/kg for 5 constitutive days. Group (4) “concomitant ZnONPs and VE-treated” was pretreated with VE 100 mg/kg/day for 14 days followed by the same dose of ZnONPs as in group (3) for 5 days. The extent of hepatic damage was evaluated by histological and immunohistochemical examination of liver samples and serological analysis of liver enzymes. Results: Body weights and liver weights showed very highly significant decrease (P <0.001) in the ZnONPs-treated group. The histological results in ZnONPs-treated group revealed congested dilated central veins and blood sinusoids, loss of normal arrangement of hepatocytes and most of hepatocytes showed marked vacuolated cytoplasm with darkly stained nuclei. Portal area affection was in the form of congested dilated portal veins with bile duct hyperplasia and cellular infiltration. There was an increase in the mount of blue stained collagen fibers around central veins together with strong positive reaction for Caspase 3 in ZnONPs-treated group. Similarly biochemical analysis indicated that the levels of serum aminotransferase (AST &ALT) significantly increased in ZnONPs-treated group when compared with other groups. Rats pretreated with VE showed improvement of the histological findings and biochemical parameters. Conclusion: Ingestion of ZnONPs could be associated with serious liver affection and pretreatment with VE is suggested to induce some improvement of such deleterious changes.

Complex effect of zinc oxide nanoparticles on cadmium chloride-induced hepatotoxicity in mice: protective role of metallothionein

Metallomics ◽  
2017 ◽  
Vol 9 (6) ◽  
pp. 706-714 ◽  
Author(s):  
Shang Gao ◽  
Xue Wang ◽  
Shasha Wang ◽  
Shanshan Zhu ◽  
Rui Rong ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Cadmium Chloride ◽  
Protective Role ◽  
Oxide Nanoparticles ◽  
Complex Effect

Protective role of zinc oxide nanoparticles in kidney injury induced by cisplatin in rats

Life Sciences ◽  
2020 ◽  
Vol 262 ◽  
pp. 118503
Author(s):  
Lamiaa A.A. Barakat ◽  
Nashwa Barakat ◽  
Mahmoud M. Zakaria ◽  
Salma M. Khirallah
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Kidney Injury ◽  
Protective Role ◽  
Oxide Nanoparticles

scholarly journals Protective Role of Qurecitin against Zinc Oxide Nanoparticles Induced Hepatotoxicity

2017 ◽  
Vol 12 (1) ◽  
pp. 30-39
Author(s):  
Mona M. Lotfy ◽  
Ibrahim A. Ibrahim ◽  
Sherif Y. Saleh ◽  
Marwa Elbeltagy ◽  
Haytham A. Ali
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Protective Role ◽  
Oxide Nanoparticles

scholarly journals Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Aaser M. Abdelazim ◽  
Islam M. Saadeldin ◽  
Ayman Abdel-Aziz Swelum ◽  
Mohamed M. Afifi ◽  
Ali Alkaladi
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Nile Tilapia ◽  
Reduced Glutathione ◽  
Protective Role ◽  
Oxide Nanoparticles ◽  
Relative Quantification ◽  
Mrna Transcripts

The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; the 2nd and 3rd groups were exposed to 1 and 2 mg/L of ZnONPs, respectively; and the 4th and 5th group were exposed to 1 and 2 mg/L of ZnONPs and treated with a (500 mg/kg diet) mixture of vitamin C and E mixture (250 mg/kg diet of each). Muscles were collected on the 7th and 15th day of treatments. Muscle malondialdehyde, reduced glutathione levels, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GR), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activities were measured after treatments. Relative quantification of SOD, CAT, GR, GPx, and GST mRNA transcripts was detected in the muscles. Results showed that MDA and GSH concentration; SOD, CAT, GR, GPx, and GST activities; and mRNA expression were significantly decreased in groups exposed to ZnONPs. Vitamins C and E significantly ameliorated the toxic effects of ZnONPs. In conclusion, vitamins C and E have the ability to ameliorate ZnONP oxidative stress toxicity in Nile tilapia.

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