scholarly journals Photoinduced ROS regulation of apoptosis and mechanism studies of iridium(iii) complex against SGC-7901 cells

RSC Advances ◽  
2017 ◽  
Vol 7 (29) ◽  
pp. 17752-17762 ◽  
Author(s):  
Cheng Zhang ◽  
Shang-Hai Lai ◽  
Hui-Hui Yang ◽  
De-Gang Xing ◽  
Chuan-Chuan Zeng ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Western Blot ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Cell Invasion ◽  
Cycle Arrest

A new iridium(iii) complex, Ir(ppy)2(FBPIP)]PF6 (Ir-1), was synthesized and characterized. The anticancer activity of the complex was investigated by cytotoxicity in vitro, apoptosis, cell invasion, autophagy, cell cycle arrest and western blot.

scholarly journals Apoptosis Induction, Cell Cycle Arrest and in Vitro Anticancer Activity of Gonothalamin in a Cancer Cell Lines

2012 ◽  
Vol 13 (10) ◽  
pp. 5131-5136 ◽  
Author(s):  
Aied M. Alabsi ◽  
Rola Ali ◽  
Abdul Manaf Ali ◽  
Sami Abdo Radman Al-Dubai ◽  
Hazlan Harun ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Apoptosis Induction ◽  
Cycle Arrest

Evaluation of anticancer activity in vitro and in vivo of iridium(iii) polypyridyl complexes

2019 ◽  
Vol 43 (22) ◽  
pp. 8566-8579 ◽  
Author(s):  
Miao He ◽  
Qiao-Yan Yi ◽  
Wen-Yao Zhang ◽  
Lan Bai ◽  
Fan Du ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Membrane Potential ◽  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Mitochondrial Membrane ◽  
Polypyridyl Complexes ◽  
Cycle Arrest

Three new iridium(iii) polypyridyl complexes were synthesized. The cytotoxic activity in vitro and in vivo, apoptosis, cell cycle arrest, mitochondrial membrane potential, ROS and the expression of Bcl-2 family proteins were investigated.

In vitro anticancer activity of pyrano[3, 2-c]chromene derivatives with both cell cycle arrest and apoptosis induction

2020 ◽  
Vol 29 (4) ◽  
pp. 617-629
Author(s):  
Ahmed M. El-Agrody ◽  
Ahmed M. Fouda ◽  
Mohammed A. Assiri ◽  
Ahmed Mora ◽  
Tarik E. Ali ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Apoptosis Induction ◽  
Cycle Arrest

scholarly journals Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro

2010 ◽  
Vol 31 (3) ◽  
pp. 361-366 ◽  
Author(s):  
Qi-fei Wu ◽  
Chang Liu ◽  
Ming-hui Tai ◽  
Dong Liu ◽  
Lei Lei ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Cell Invasion ◽  
Cycle Arrest ◽  
Sirna Interference

Apoptosis, autophagy, cell cycle arrest, cell invasion and BSA-binding studies in vitro of ruthenium(ii) polypyridyl complexes

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63143-63155 ◽  
Author(s):  
Shang-Hai Lai ◽  
Wei Li ◽  
Xiu-Zhen Wang ◽  
Cheng Zhang ◽  
Chuan-Chuan Zeng ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Comet Assay ◽  
Western Blot ◽  
Cell Invasion ◽  
Blot Analysis ◽  
Binding Studies ◽  
Polypyridyl Complexes ◽  
Cycle Arrest ◽  
Bsa Binding

Four new ruthenium(ii) polypyridyl complexes were synthesized and characterized. The anticancer activity was investigated by cytotoxicity in vitro, apoptosis, comet assay, ROS, autophagy, cell invasion and western blot analysis.

scholarly journals Novel Benzenesulfonate Scaffolds with a High Anticancer Activity and G2/M Cell Cycle Arrest

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1790
Author(s):  
Katarzyna Malarz ◽  
Jacek Mularski ◽  
Michał Kuczak ◽  
Anna Mrozek-Wilczkiewicz ◽  
Robert Musiol
Keyword(s):  
Cell Cycle ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Anticancer Agents ◽  
Kinase Inhibitors ◽  
P53 Protein ◽  
Structural Similarity ◽  
M Cell ◽  
Cycle Arrest ◽  
Small Series

Sulfonates, unlike their derivatives, sulphonamides, have rarely been investigated for their anticancer activity. Unlike the well-known sulphonamides, esters are mainly used as convenient intermediates in a synthesis. Here, we present the first in-depth investigation of quinazoline sulfonates. A small series of derivatives were synthesized and tested for their anticancer activity. Based on their structural similarity, these compounds resemble tyrosine kinase inhibitors and the p53 reactivator CP-31398. Their biological activity profile, however, was more related to sulphonamides because there was a strong cell cycle arrest in the G2/M phase. Further investigation revealed a multitargeted mechanism of the action that corresponded to the p53 protein status in the cell. Although the compounds expressed a high submicromolar activity against leukemia and colon cancers, pancreatic cancer and glioblastoma were also susceptible. Apoptosis and autophagy were confirmed as the cell death modes that corresponded with the inhibition of metabolic activity and the activation of the p53-dependent and p53-independent pathways. Namely, there was a strong activation of the p62 protein and GADD44. Other proteins such as cdc2 were also expressed at a higher level. Moreover, the classical caspase-dependent pathway in leukemia was observed at a lower concentration, which again confirmed a multitargeted mechanism. It can therefore be concluded that the sulfonates of quinazolines can be regarded as promising scaffolds for developing anticancer agents.

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