scholarly journals In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups

RSC Advances ◽  
2017 ◽  
Vol 7 (39) ◽  
pp. 23942-23953 ◽  
Author(s):  
Zhihong Zhu ◽  
Dongyang Li ◽  
Yuenan Li ◽  
Xinggang Yang ◽  
Weisan Pan
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymers ◽  
In Vivo Evaluation ◽  
Therapeutic Applications

Polymeric micelles are widely used as suitable nano-carriers for a variety of therapeutic applications.

scholarly journals Correction: In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups

RSC Advances ◽  
2017 ◽  
Vol 7 (48) ◽  
pp. 30049-30050
Author(s):  
Zhihong Zhu ◽  
Dongyang Li ◽  
Yuenan Li ◽  
Xinggang Yang ◽  
Weisan Pan
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Amphiphilic Copolymers ◽  
In Vivo Evaluation

Correction for ‘In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups’ by Zhihong Zhu et al., RSC Adv., 2017, 7, 23942–23953.

Hyaluronic acid-coated liposomes for targeted delivery of paclitaxel, in-vitro characterization and in-vivo evaluation

2016 ◽  
Vol 229 ◽  
pp. 10-22 ◽  
Author(s):  
Fatemeh Ravar ◽  
Ebrahim Saadat ◽  
Mehdi Gholami ◽  
Pouya Dehghankelishadi ◽  
Mehdi Mahdavi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
In Vivo Evaluation ◽  
In Vitro Characterization

scholarly journals Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Wei Zhang ◽  
Guoyu Yin ◽  
Heping Zhao ◽  
Hanzhi Ling ◽  
Zhen Xie ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Dependent Manner ◽  
Collagen Induced Arthritis ◽  
Intracellular Degradation ◽  
Main Pathway ◽  
First Time

AbstractIn inflamed joints, enhanced hyaluronic acid (HA) degradation is closely related to the pathogenesis of rheumatoid arthritis (RA). KIAA1199 has been identified as a hyaladherin that mediates the intracellular degradation of HA, but its extracellular function remains unclear. In this study, we found that the serum and synovial levels of secreted KIAA1199 (sKIAA1199) and low-molecular-weight HA (LMW-HA, MW < 100 kDa) in RA patients were significantly increased, and the positive correlation between them was shown for the first time. Of note, treatment with anti-KIAA1199 mAb effectively alleviated the severity of arthritis and reduced serum LMW-HA levels and cytokine secretion in collagen-induced arthritis (CIA) mice. In vitro, sKIAA1199 was shown to mediate exogenous HA degradation by attaching to the cell membrane of RA fibroblast-like synoviosytes (RA FLS). Furthermore, the HA-degrading activity of sKIAA1199 depended largely on its adhesion to the membrane, which was achieved by its G8 domain binding to ANXA1. In vivo, kiaa1199-KO mice exhibited greater resistance to collagen-induced arthritis. Interestingly, this resistance could be partially reversed by intra-articular injection of vectors encoding full-length KIAA1199 instead of G8-deleted KIAA119 mutant, which further confirmed the indispensable role of G8 domain in KIAA1199 involvement in RA pathological processes. Mechanically, the activation of NF-κB by interleukin-6 (IL-6) through PI3K/Akt signaling is suggested to be the main pathway to induce KIAA1199 expression in RA FLS. In conclusion, our study supported the contribution of sKIAA1199 to RA pathogenesis, providing a new therapeutic target for RA by blocking sKIAA1199-mediated HA degradation.

CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation

2018 ◽  
Vol 280 ◽  
pp. 20-30 ◽  
Author(s):  
Hae-Yong Seok ◽  
N. Sanoj Rejinold ◽  
Kamali Manickavasagam Lekshmi ◽  
Kondareddy Cherukula ◽  
In-Kyu Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
In Vivo Evaluation ◽  
Cd44 Targeting

scholarly journals Reassessing the Role of Intra-Arterial Drug Delivery for Glioblastoma Multiforme Treatment

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Jason A. Ellis ◽  
Matei Banu ◽  
Shaolie S. Hossain ◽  
Rajinder Singh-Moon ◽  
Sean D. Lavine ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Optical Measurements ◽  
Pharmacological Agents ◽  
Cellular Targets ◽  
Therapeutic Landscape ◽  
Rational Drug

Effective treatment for glioblastoma (GBM) will likely require targeted delivery of several specific pharmacological agents simultaneously. Intra-arterial (IA) delivery is one technique for targeting the tumor site with multiple agents. Although IA chemotherapy for glioblastoma (GBM) has been attempted since the 1950s, the predicted benefits remain unproven in clinical practice. This review focuses on innovative approaches to IA drug delivery in treating GBM. Guided by novel in vitro and in vivo optical measurements, newer pharmacokinetic models promise to better define the complex relationship between background cerebral blood flow and drug injection parameters. Advanced optical technologies and tracers, unique nanoparticles designs, new cellular targets, and rational drug formulations are continuously modifying the therapeutic landscape for GBM. Personalized treatment approaches are emerging; however, such tailored approaches will largely depend on effective drug delivery techniques and on the ability to simultaneously deliver multidrug regimens. These new paradigms for tumor-selective drug delivery herald dramatic improvements in the effectiveness of IA chemotherapy for GBM. Therefore, within this context of so-called “precision medicine,” the role of IA delivery for GBM is thoroughly reassessed.

In Vitro and In Vivo Evaluation of a Multifunctional Hyaluronic acid Based Hydrogel System for Local Application on the Retina

2011 ◽  
Vol 309-310 (1) ◽  
pp. 229-235 ◽  
Author(s):  
A. T. Neffe ◽  
K. A. Kobuch ◽  
M. Maier ◽  
N. Feucht ◽  
C. P. Lohmann ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Local Application ◽  
In Vivo Evaluation ◽  
Hydrogel System

Novel folate-targeted docetaxel-loaded nanoparticles for tumour targeting: in vitro and in vivo evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64306-64314 ◽  
Author(s):  
M. H. Han ◽  
Z. T. Li ◽  
D. D. Bi ◽  
Y. F. Guo ◽  
H. X. Kuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Tumour Targeting ◽  
Breast Cancer Therapy ◽  
In Vivo Evaluation ◽  
Targeted Delivery System

Cholesterol-PEG1000-FA (folic acid) was synthesized as a stabilizer to encapsulate DTX, for the construction of a promising targeted delivery system for breast cancer therapy.

scholarly journals The anticancer efficacy of paclitaxel liposomes modified with low-toxicity hydrophobic cell-penetrating peptides in breast cancer: an in vitro and in vivo evaluation

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24084-24093 ◽  
Author(s):  
Qi Zhang ◽  
Jing Wang ◽  
Hao Zhang ◽  
Dan Liu ◽  
Linlin Ming ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
In Vivo Evaluation ◽  
Anticancer Efficacy ◽  
Cell Penetrating ◽  
Low Toxicity

Hydrophobic cell penetrating peptide PFVYLI-modified liposomes have been developed for the targeted delivery of PTX into tumors.

Sign in / Sign up

Export Citation Format

Share Document