scholarly journals In vivo biodistribution and passive accumulation of upconversion nanoparticles in colorectal cancer models via intraperitoneal injection

RSC Advances ◽  
2017 ◽  
Vol 7 (50) ◽  
pp. 31588-31596 ◽  
Author(s):  
Yilin Gao ◽  
Xingjun Zhu ◽  
Yuwen Zhang ◽  
Xiaofeng Chen ◽  
Li Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Intraperitoneal Injection ◽  
Upconversion Nanoparticles ◽  
Tumour Targeting ◽  
Biological Processes ◽  
In Vivo Biodistribution ◽  
Cancer Models ◽  
Targeting Effectiveness

Cit-UCNPs after IP injection exhibited significantly different biological processes from those after IV injection. The passive-tumour targeting effectiveness of cit-UCNPs via the IP route was higher than that via the IV route.

In-vivo longitudinal photoacoustic tomography of the response of colorectal cancer models to vascular targeted therapy

2016 ◽  
Author(s):  
O Ogunlade ◽  
SP Johnson ◽  
E Zhang ◽  
V Rajkumar ◽  
RB Pedley ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Targeted Therapy ◽  
Photoacoustic Tomography ◽  
Cancer Models

In vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice

2020 ◽  
pp. 403-429
Author(s):  
Zhuang Liu ◽  
Weibo Cai ◽  
Lina He ◽  
Nozomi Nakayama ◽  
Kai Chen ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tumour Targeting ◽  
Highly Efficient ◽  
In Vivo Biodistribution

scholarly journals Influence of size, surface coating and fine chemical composition on the in vitro reactivity and in vivo biodistribution of lipid nanocapsules versus lipid nanoemulsions in cancer models

2013 ◽  
Vol 9 (3) ◽  
pp. 375-387 ◽  
Author(s):  
Samuli Hirsjärvi ◽  
Sandrine Dufort ◽  
Julien Gravier ◽  
Isabelle Texier ◽  
Qiao Yan ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Surface Coating ◽  
Lipid Nanocapsules ◽  
Fine Chemical ◽  
In Vivo Biodistribution ◽  
Cancer Models

scholarly journals A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 227
Author(s):  
Eileen Reidy ◽  
Niamh A. Leonard ◽  
Oliver Treacy ◽  
Aideen E. Ryan
Keyword(s):  
Colorectal Cancer ◽  
3D Model ◽  
Treatment Options ◽  
3D Models ◽  
In Vivo Studies ◽  
The Past ◽  
Monolayer Cultures ◽  
Cancer Models

Although there have been many advances in recent years for the treatment of colorectal cancer (CRC), it still remains the third most common cause of cancer-related deaths worldwide. Many patients with late stage CRC display resistance to multiple different therapeutics. An important aspect in developing effective therapeutics for CRC patients is understanding the interactions that take place in the tumor microenvironment (TME), as it has been shown to contribute to drug resistance in vivo. Much research over the past 100 years has focused on 2D monolayer cultures or in vivo studies, however, the efficacy in translating these to the clinic is very low. More recent studies are turning towards developing an effective 3D model of CRC that is clinically relevant, that can recapitulate the TME in vitro and bridge the gap between 2D cultures and in vivo studies, with the aim of reducing the use of animal models in the future. This review summarises the advantages and limitations of different 3D CRC models. It emphasizes how different 3D models may be optimised to study cellular and extracellular interactions that take place in the TME of CRC in an effort to allow the development of more translatable effective treatment options for patients.

In vivo biodistribution and toxicity of Gd2O3:Eu3+ nanotubes in mice after intraperitoneal injection

RSC Advances ◽  
2015 ◽  
Vol 5 (90) ◽  
pp. 73601-73611 ◽  
Author(s):  
Huifang Liu ◽  
Guang Jia ◽  
Shizhu Chen ◽  
Huanyun Ma ◽  
Yanyan Zhao ◽  
...  
Keyword(s):  
Human Health ◽  
Intraperitoneal Injection ◽  
Hepatic Injury ◽  
Subacute Toxicity ◽  
In Vivo Biodistribution ◽  
Potential Impact

To better understand the potential impact of Gd2O3:Eu3+ nanotubes on human health, we investigated their biodistribution, subacute toxicity, and hepatic injury in mice under different dosages (4.0, 40.0, and 400.0 mg kg−1).

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

2006 ◽  
Vol 2 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Zhuang Liu ◽  
Weibo Cai ◽  
Lina He ◽  
Nozomi Nakayama ◽  
Kai Chen ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tumour Targeting ◽  
Highly Efficient ◽  
In Vivo Biodistribution

scholarly journals Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Aurélie Rondon ◽  
Nancy Ty ◽  
Jean-Baptiste Bequignat ◽  
Mercedes Quintana ◽  
Arnaud Briat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
In Vivo Evaluation ◽  
Cancer Models

scholarly journals CEA-targeted nanoparticles allow specific in vivo fluorescent imaging of colorectal cancer models

Nanomedicine ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. 1223-1231 ◽  
Author(s):  
James P Tiernan ◽  
Nicola Ingram ◽  
Gemma Marston ◽  
Sarah L Perry ◽  
Jo V Rushworth ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fluorescent Imaging ◽  
Targeted Nanoparticles ◽  
Cancer Models
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