fine chemical
Recently Published Documents


TOTAL DOCUMENTS

351
(FIVE YEARS 41)

H-INDEX

34
(FIVE YEARS 5)

2021 ◽  
pp. 106389
Author(s):  
Xinwei Li ◽  
Mengqing Li ◽  
Jianguo Liu ◽  
Jiayu Yi ◽  
Min-Quan Yang ◽  
...  

Chem ◽  
2021 ◽  
Vol 7 (11) ◽  
pp. 2927-2942
Author(s):  
Jacob Davies ◽  
Julien R. Lyonnet ◽  
Dmitry P. Zimin ◽  
Ruben Martin
Keyword(s):  

2021 ◽  
Author(s):  
Kaid Harper ◽  
Timothy Grieme ◽  
Timothy Towne ◽  
Daniel Mack ◽  
Moiz Diwan ◽  
...  

Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow. In this report, a photoredox trifluoromethylation of a thiophenol was modified from the original literature report and the mechanism was investigated to define key scale-up parameters. The mechanistic insight was leveraged in the design and execution of two different reactor designs: an LED-based plug flow photoreactor as well as a laser-based continuous stirred tank photoreactor. In one of the first examples of commercial scale photoredox chemistry, the process was scaled to provide over 500 kilograms of the desired intermediate and amended to fully continuous manufacturing.


2021 ◽  
pp. 193-228
Author(s):  
Antonio M. Rodríguez ◽  
Iván Torres-Moya ◽  
Angel Díaz-Ortiz ◽  
Antonio de la Hoz ◽  
Jesús Alcázar

CONVERTER ◽  
2021 ◽  
pp. 212-219
Author(s):  
Qing Xu, Xiaolan Wang, Wenhao Ying

The article utilizes Citespace software to analyze the existing research literature, uses the method of word frequency analysis to conduct content mining and data processing on the journal literature in the field of precision funding fine chemical industryresearch in colleges and universities, and analyzes the history and research of the precision funding of colleges and universities for students with financial difficulties in recent years. The current situation is expected to provide reference and reference for follow-up researchers, and to provide ideas and suggestions for practically improving the level of university funding.


2021 ◽  
pp. 44-53
Author(s):  
Attiya Rasool

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous medical agents with widely divergent chemical structures and biological activities, including antimicrobial, immunosuppressive, anticancer, and anti-inflammatory activities, many of which have been developed as treatments and have potential therapeutic applications for human diseases. Aside from natural products, the recent development of recombinant DNA technology has sparked the development of a wide array of biopharmaceutical products, such as recombinant proteins, offering significant advances in treating a broad spectrum of medical illnesses and conditions. Fine chemicals that are physiologically active, such as pharmaceuticals, cosmetics, nutritional supplements, flavoring agents as well as additives for foods, feed, and fertilizer are produced by enzymatically or through microbial fermentation. The identification of enzymes that catalyze the target reaction makes possible to synthesis of the desired fine chemical. The genes encoding these enzymes are then introduced into suitable microbial hosts that are cultured with inexpensive, naturally abundant carbon sources, and other nutrients. Metabolic engineering create efficient microbial cell factories for producing chemicals at higher yields. In the present review, we summarize recent studies on bio-based fine chemical production and assess the potential of synthetic bioengineering for further improvement their productivity.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Simon J. Moore ◽  
Yonek B. Hleba ◽  
Sarah Bischoff ◽  
David Bell ◽  
Karen M. Polizzi ◽  
...  

Abstract Background  A key focus of synthetic biology is to develop microbial or cell-free based biobased routes to value-added chemicals such as fragrances. Originally, we developed the EcoFlex system, a Golden Gate toolkit, to study genes/pathways flexibly using Escherichia coli heterologous expression. In this current work, we sought to use EcoFlex to optimise a synthetic raspberry ketone biosynthetic pathway. Raspberry ketone is a high-value (~ £20,000 kg−1) fine chemical farmed from raspberry (Rubeus rubrum) fruit. Results  By applying a synthetic biology led design-build-test-learn cycle approach, we refactor the raspberry ketone pathway from a low level of productivity (0.2 mg/L), to achieve a 65-fold (12.9 mg/L) improvement in production. We perform this optimisation at the prototype level (using microtiter plate cultures) with E. coli DH10β, as a routine cloning host. The use of E. coli DH10β facilitates the Golden Gate cloning process for the screening of combinatorial libraries. In addition, we also newly establish a novel colour-based phenotypic screen to identify productive clones quickly from solid/liquid culture. Conclusions  Our findings provide a stable raspberry ketone pathway that relies upon a natural feedstock (L-tyrosine) and uses only constitutive promoters to control gene expression. In conclusion we demonstrate the capability of EcoFlex for fine-tuning a model fine chemical pathway and provide a range of newly characterised promoter tools gene expression in E. coli.


Sign in / Sign up

Export Citation Format

Share Document