scholarly journals Effects of polyethylene oxide and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibrous substrate on omental adipose-derived mesenchymal stem cell neuronal differentiation and peripheral nerve regeneration

RSC Advances ◽  
2017 ◽  
Vol 7 (68) ◽  
pp. 42833-42844 ◽  
Author(s):  
Feihu Hu ◽  
Ting Chen ◽  
Wei Wang
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neuronal Differentiation ◽  
Polyethylene Oxide ◽  
Peripheral Nerve Regeneration ◽  
Electrospun Nanofibres ◽  
Biomedical Fields

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polyethylene oxide (PEO) display biodegradable and biocompatible properties for applications in the biomedical fields. PEO incorporated with PHBV fabricates superior electrospun nanofibres.

scholarly journals The effect of human umbilical cord-derived mesenchymal stem cell conditioned medium on the peripheral nerve regeneration of injured rats

2019 ◽  
Vol 16 (6) ◽  
pp. em171
Author(s):  
Jeanne Adiwinata Pawitan ◽  
Ria Margiana ◽  
Renindra Ananda Aman ◽  
Ahmad Aulia Jusuf ◽  
Nurhadi Ibrahim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Conditioned Medium ◽  
Umbilical Cord ◽  
Peripheral Nerve Regeneration ◽  
Human Umbilical Cord ◽  
Cell Conditioned Medium

Growth factor and stem cell enhanced conduits in peripheral nerve regeneration and repair

2008 ◽  
Vol 30 (10) ◽  
pp. 1030-1038 ◽  
Author(s):  
Stephen W. P. Kemp ◽  
Sarah K. Walsh ◽  
Rajiv Midha
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration

Peripheral nerve injury therapeutics, including electrical stimulation, stem cell treatments, and synthetic neural scaffolds, have shown promising preclinical and even clinical results with potential regenerative treatment

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cell ◽  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Clinical Results ◽  
Preclinical Research ◽  
Cell Therapies ◽  
Nerve Recovery

In the U.S., peripheral nerve injuries (PNI) harm about 22 million people. The most frequent causes and types of PNI vary by demography (civilians vs. military, geography/country). After crush injuries, functional recovery is better than after transections, and better after distal injuries than proximal ones. Despite advancements in microsurgical treatments, severe PNIs remain connected to slow recovery. This review highlights new peripheral nerve regeneration approaches (e.g. electrical stimulation, cell therapies), which may lead to a shift in PNI therapeutic paradigms in conjunction with neurotrophic agents and breakthroughs in bioscaffold engineering. It also examines how synthetic neural scaffolds can aid with peripheral nerve recovery, as well as the next generation of biomimetic neural scaffolding that can aid in tissue regeneration. Neurotrophic factor-enriched neural scaffolds, stem cell treatments, and electrical stimulation have shown promising preclinical and even clinical results. The future of peripheral nerve regeneration is bright, since a combination of the aforementioned treatments may have a synergistic impact on nerve regeneration and functional recovery in patients with PNI. Stem cell technology is improving and evolving, and it has been explored through a number of methods in preclinical research for peripheral nerve regeneration. Electrical stimulation is another interesting potential treatment for PNI that may be used to stimulate axon regeneration.

scholarly journals MODERN METHODS OF SURGICAL TREATMENT OF PERIPHERAL NERVOUS SYSTEM INJURIES

2020 ◽  
Vol 8 (4) ◽  
pp. 424-432
Author(s):  
O.O. Potapov ◽  
O.P. Kmyta ◽  
O.O. Tsyndrenko ◽  
M.I. Semenyuk ◽  
A.V. Senchenko
Keyword(s):  
Stem Cell ◽  
Surgical Treatment ◽  
Cell Therapy ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Military Operations ◽  
Treatment Methods ◽  
Peripheral Nerve Damage ◽  
Working Age

In Ukraine, 2,500–3,000 people sustain peripheral nerve injuries every year. Often these are young people of working age. In the structure of total injuries, peripheral nerve damage in peacetime makes 1.5–6%, and during military operations (taking into account the situation in the east of Ukraine), this value ranges from 9 to 25% due to gunshot injuries. Analysis of medical literature and publications over the past five years was carried out, with due attention to the studies related to modern surgical treatment methods of peripheral nerve traumatic injuries. The problem of surgical treatment has not been thoroughly studied. Peripheral nerve regeneration is a complex process, and therefore the existing treatment methods are limited due to slow nerve regeneration and insufficient spanning of large post-traumatic nerve defects. To overcome these limitations, a cell therapy has been developed that ensures the presence of supporting cells at the site of the lesion in order to accelerate nerve regeneration. Schwann cells play an important role in many aspects of nerve regeneration. Stem cell transplantation for peripheral nerve regeneration represents alternative cell therapy with several regenerative benefits. Various types of stem cell sources are currently being investigated for use for peripheral nerve regeneration in combination with the most optimal nerve guide conduit.

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