Regulation of both the structure and function by a de novo designed disulfide bond: a case study of heme proteins in myoglobin

2018 ◽  
Vol 54 (34) ◽  
pp. 4356-4359 ◽  
Author(s):  
Lu-Lu Yin ◽  
Hong Yuan ◽  
Ke-Jie Du ◽  
Bo He ◽  
Shu-Qin Gao ◽  
...  
Keyword(s):  
Disulfide Bond ◽  
Heme Proteins ◽  
De Novo ◽  
Structure And Function ◽  
Intramolecular Disulfide Bond ◽  
And Function

The V21C/V66C/F46S myoglobin mutant, with a de novo designed intramolecular disulfide bond resembling that in cytoglobin without structural evidence, exhibits a dehalogenation activity exceeding that of a native dehaloperoxidase.

scholarly journals riboCIRC: a comprehensive database of translatable circRNAs

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Huihui Li ◽  
Mingzhe Xie ◽  
Yan Wang ◽  
Ludong Yang ◽  
Zhi Xie ◽  
...  
Keyword(s):  
De Novo ◽  
Species Conservation ◽  
Structure And Function ◽  
Research Community ◽  
Genome Browser ◽  
Valuable Resource ◽  
Sequence Structure ◽  
A Genome ◽  
Context Specific ◽  
And Function

AbstractriboCIRC is a translatome data-oriented circRNA database specifically designed for hosting, exploring, analyzing, and visualizing translatable circRNAs from multi-species. The database provides a comprehensive repository of computationally predicted ribosome-associated circRNAs; a manually curated collection of experimentally verified translated circRNAs; an evaluation of cross-species conservation of translatable circRNAs; a systematic de novo annotation of putative circRNA-encoded peptides, including sequence, structure, and function; and a genome browser to visualize the context-specific occupant footprints of circRNAs. It represents a valuable resource for the circRNA research community and is publicly available at http://www.ribocirc.com.

Disulfide Bond Mutagenesis and the Structure and Function of the Head-to-Tail Macrocyclic Trypsin Inhibitor SFTI-1†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (4) ◽  
pp. 1145-1153 ◽  
Author(s):  
Michael L. J. Korsinczky ◽  
Richard J. Clark ◽  
David J. Craik
Keyword(s):  
Disulfide Bond ◽  
Trypsin Inhibitor ◽  
Structure And Function ◽  
And Function

scholarly journals Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli

2011 ◽  
Vol 11 (1) ◽  
pp. 74 ◽  
Author(s):  
Larissa Tetsch ◽  
Christiane Koller ◽  
Alexandra Dönhöfer ◽  
Kirsten Jung
Keyword(s):  
Escherichia Coli ◽  
Disulfide Bond ◽  
Ph Responsive ◽  
Intramolecular Disulfide Bond ◽  
And Function
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