scholarly journals Direct observation of the oxidation of DNA bases by phosphate radicals formed under radiation: a model of the backbone-to-base hole transfer

2018 ◽  
Vol 20 (21) ◽  
pp. 14927-14937 ◽  
Author(s):  
Jun Ma ◽  
Jean-Louis Marignier ◽  
Pascal Pernot ◽  
Chantal Houée-Levin ◽  
Anil Kumar ◽  
...  
Keyword(s):  
Direct Observation ◽  
Dna Bases ◽  
Hole Transfer ◽  
Transfer Processes ◽  
Oxidation Of Dna ◽  
Unpaired Spin

In irradiated DNA, by the base-to-base and backbone-to-base hole transfer processes, the hole (i.e., the unpaired spin) localizes on the most electropositive base, guanine.

Hole Transfer Processes in meta- and para-Conjugated Mixed Valence Compounds: Unforeseen Effects of Bridge Substituents and Solvent Dynamics

2017 ◽  
Vol 139 (17) ◽  
pp. 6200-6209 ◽  
Author(s):  
Julian Schäfer ◽  
Marco Holzapfel ◽  
Boryana Mladenova ◽  
Daniel Kattnig ◽  
Ivo Krummenacher ◽  
...  
Keyword(s):  
Mixed Valence ◽  
Hole Transfer ◽  
Transfer Processes ◽  
Solvent Dynamics ◽  
Mixed Valence Compounds

The antileishmanial drug miltefosine (Impavido ® ) causes oxidation of DNA bases, apoptosis, and necrosis in mammalian cells

2016 ◽  
Vol 806 ◽  
pp. 34-39 ◽  
Author(s):  
Patrícia Valéria Castelo Branco ◽  
Rossy-Eric Pereira Soares ◽  
Luís Cláudio Lima de Jesus ◽  
Vanessa Ribeiro Moreira ◽  
Hugo José Alves ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Dna Bases ◽  
Oxidation Of Dna ◽  
Antileishmanial Drug ◽  
Apoptosis And Necrosis

The Equine Estrogen Metabolite 4-Hydroxyequilenin Causes DNA Single-Strand Breaks and Oxidation of DNA Bases in Vitro

1998 ◽  
Vol 11 (9) ◽  
pp. 1105-1111 ◽  
Author(s):  
Yumei Chen ◽  
Li Shen ◽  
Fagen Zhang ◽  
Serrine S. Lau ◽  
Richard B. van Breemen ◽  
...  
Keyword(s):  
Single Strand ◽  
Dna Bases ◽  
Strand Breaks ◽  
Estrogen Metabolite ◽  
Oxidation Of Dna ◽  
Single Strand Breaks

Oxidation of DNA Bases Influenced by the Presence of Other Bases

2012 ◽  
Vol 24 (5) ◽  
pp. 1147-1152 ◽  
Author(s):  
Madeline Shuhua Goh ◽  
Martin Pumera
Keyword(s):  
Dna Bases ◽  
Oxidation Of Dna

scholarly journals Photosensitized one-electron oxidation of DNA

2005 ◽  
Vol 77 (6) ◽  
pp. 963-975 ◽  
Author(s):  
Kiyohiko Kawai ◽  
Tetsuro Majima
Keyword(s):  
Dna Damage ◽  
High Performance ◽  
Transient Absorption ◽  
Basic Mechanism ◽  
Absorption Measurement ◽  
Mechanistic Study ◽  
Hole Transfer ◽  
Damage Quantification ◽  
Oxidation Of Dna ◽  
Kinetics Of

Photosensitized one-electron oxidation of DNA has attracted much interest because it causes oxidative damage which leads to mutation, and because it is involved in the basic mechanism of photodynamic therapy. In the present article, we describe the mechanistic study of photosensitized DNA damage, especially addressing the kinetics of hole transfer by adenine(A)-hopping and its effect on the DNA damage. The combination of the transient absorption measurement and DNA damage quantification by high-performance liquid chromatography clearly demonstrate that the yield of the DNA damage correlates well with the lifetime of the charge-separated state caused by A-hopping, showing that hole transfer helps DNA damage. These findings led us to propose a new method to accomplish the efficient DNA damage using a combination of two-color, two-laser irradiation.

Direct Observation of Ultrafast Dynamics in DNA Bases

2007 ◽  
pp. 486-488
Author(s):  
Helmut Satzger ◽  
Dave Townsend ◽  
Marek Z. Zgierski ◽  
Albert Stolow
Keyword(s):  
Direct Observation ◽  
Dna Bases ◽  
Ultrafast Dynamics

Direct Observation of Ultrafast Dynamics in DNA Bases

2006 ◽  
Author(s):  
H. Satzger ◽  
D. Townsend ◽  
M. Z. Zgierski ◽  
A. Stolow
Keyword(s):  
Direct Observation ◽  
Dna Bases ◽  
Ultrafast Dynamics
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