scholarly journals Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles

2018 ◽  
Vol 20 (12) ◽  
pp. 2775-2780 ◽  
Author(s):  
Dong Wang ◽  
Linna Li ◽  
Hairong Feng ◽  
Hua Sun ◽  
Fabrice Almeida-Veloso ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
Three Component Reaction ◽  
One Step

An efficient catalyst-free synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and α-ketoamides.

Uncatalyzed, on water oxygenative cleavage of inert C–N bond with concomitant 8,7-amino shift in 8-aminoquinoline derivatives

2019 ◽  
Vol 21 (7) ◽  
pp. 1735-1742 ◽  
Author(s):  
Vinayak Botla ◽  
NavyaSree Pilli ◽  
Chandrasekharam Malapaka
Keyword(s):  
Room Temperature ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
One Step

Oxygenative cleavage of an inert CAr–NH2 bond with concomitant 1,2 amine migration in 8-aminoquinoline derivatives is achieved through an efficient, catalyst free, one step synthesis of 8-benzyloxy, 7-aminoquinoline directly from 8-aminoquinoline in water at room temperature.

CeCl3·7H2O as mild and efficient catalyst for the one-pot multicomponent synthesis of 8-aryl-7,8-dihydro[1,3]dioxolo[4,5-g]chromen-6-ones

2011 ◽  
Vol 76 (4) ◽  
pp. 235-241 ◽  
Author(s):  
Li-Qiang Wu ◽  
Wei-Lin Li ◽  
Fu-Lin Yan
Keyword(s):  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Work Up

A series of new 8-aryl-7,8-dihydro[1,3]dioxolo[4,5-g]chromen-6-ones were synthesized via a three-component reaction of 3,4-methylenedioxyphenol, aromatic aldehydes and Meldrum’s acid in the presence of CeCl3·7H2O under solvent-free conditions. The method provided several advantages such as easy work-up, high yields and environmentally benign procedure.

One-Pot Solvent-and Catalyst-Free Synthesis of Some New Heteroarylaminonaphthoquinones from Lawsone

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Nilufar Rahmani ◽  
Mahdieh Sadeghpour ◽  
Amir Mohamadi
Keyword(s):  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Heterocyclic Amines ◽  
Environmentally Benign ◽  
One Pot ◽  
Simple Operation ◽  
Catalyst Free ◽  
Three Component Reaction ◽  
Methyl Naphthalene ◽  
Work Up

: A clean and efficient one-pot protocol for the synthesis of a series of new 2-hydroxy-3-((3-aryl)(heteroarylamino)methyl)naphthalene-1,4-dione derivatives has been developed by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and heterocyclic amines at 90 oC under solvent and catalyst-free conditions. The procedure avoids the use of toxic solvents, tedious work-up, catalyst and purification of the products by chromatographic methods. Simple operation, short reaction times, generating the desired compounds in high to excellent yields and an environmentally benign method are advantages of this protocol.

scholarly journals Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions

Synthesis ◽  
2020 ◽  
Vol 52 (08) ◽  
pp. 1279-1286
Author(s):  
Kamal K. Rajbongshi ◽  
Srinivas Ambala ◽  
Thavendran Govender ◽  
Hendrik G. Kruger ◽  
Per I. Arvidsson ◽  
...  
Keyword(s):  
Free Radical ◽  
Microwave Irradiation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aromatic Aldehydes ◽  
Efficient Catalyst ◽  
Radical Initiator ◽  
Catalyst Free ◽  
Broad Scope ◽  
Cross Coupling Reaction

An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines was developed. The reaction took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in moderate to excellent yields (27 examples). This protocol proved to be rapid, easy to handle, and applicable to a broad scope of substrates.

scholarly journals Trichloroisocyanuric acid, a New and Efficient Catalyst for the Synthesis of 2′- Aminobenzothiazolo-arylmethyl-2-naphthols

2012 ◽  
Vol 9 (4) ◽  
pp. 2424-2428 ◽  
Author(s):  
Limin Yang
Keyword(s):  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Solvent Free ◽  
One Pot ◽  
Efficient Catalyst ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
Trichloroisocyanuric Acid

An efficient one-pot synthesis of 2′-aminobenzothiazolo-arylmethyl-2-naphthols is described. This involves the three-component reaction ofβ-naphthol, aromatic aldehydes and 2-aminobenzothiazole in the presence of a catalytic amount of trichloroisocyanuric acid under solvent-free conditions.

scholarly journals Synthesis of (E)-5-Arylvinyl-7-methyltetrazolo[1,5-a]pyrimidines

2021 ◽  
Vol 91 (4) ◽  
pp. 621-625
Author(s):  
V. L. Gein ◽  
A. N. Prudnikova ◽  
A. A. Kurbatova ◽  
M. V. Dmitriev
Keyword(s):  
Aromatic Aldehydes ◽  
Side Product ◽  
Catalyst Free ◽  
Three Component Reaction

Abstract A three-component reaction of 5-aminotetrazole with aromatic aldehydes and acetylacetone under solvent- and catalyst-free conditions at a temperature of 150–160°С proceeds with the formation of (E)-5-arylvinyl-7-methyltetrazolo[1,5-a]pyrimidines. 5,7-Dimethyltetrazolo[1,5-a]pyrimidine is formed as a side-product of the reaction.

Catalyst-Free Three-Component Synthesis of Spirobenzimidazolidines Bearing an Indole Scaffold

Synlett ◽  
2018 ◽  
Vol 29 (17) ◽  
pp. 2301-2305 ◽  
Author(s):  
F. Moghaddam ◽  
A. Moafi ◽  
Z. Zamani ◽  
M. Daneshfar
Keyword(s):  
Reaction Times ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
New Family ◽  
Three Component Reaction ◽  
High Yields ◽  
First Time ◽  
Derivatives Of

An efficient catalyst-free one-pot three-component reaction was developed for the synthesis of a new family of N- and S-containing spirocyclic compounds. Various derivatives of spirobenzimidazolidine containing an indole scaffold were synthesized for the first time in a modestly toxic solvent and under mild reaction conditions. The reaction times were of the order of several minutes, and all the products were obtained in moderate to high yields (overall yields 58–80%).

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