Disassembly and tumor-targeting drug delivery of reduction-responsive degradable block copolymer nanoassemblies

2019 ◽  
Vol 10 (13) ◽  
pp. 1554-1568 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages

Review on recent strategies to synthesize novel disulfide-containing reductively-degradable block copolymers and their nanoassemblies as being classified with the number, position, and location of the disulfide linkages toward effective tumor-targeting intracellular drug delivery exhibiting enhanced release of encapsulated drugs.

Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations

2019 ◽  
Vol 10 (22) ◽  
pp. 2840-2853 ◽  
Author(s):  
Arman Moini Jazani ◽  
Newsha Arezi ◽  
Chaitra Shetty ◽  
Sung Hwa Hong ◽  
Haowen Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Acid Reduction

Dual acid/reduction-degradable block copolymer nanoassemblies both at core/corona interfaces and in micellar cores leading to synergistic and accelerated drug release for robust tumor-targeting intracellular drug delivery.

Intracellular Drug Delivery Nanocarriers of Glutathione-Responsive Degradable Block Copolymers Having Pendant Disulfide Linkages

2013 ◽  
Vol 14 (6) ◽  
pp. 2103-2111 ◽  
Author(s):  
Behnoush Khorsand ◽  
Gabriel Lapointe ◽  
Christopher Brett ◽  
Jung Kwon Oh
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages

Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy

2016 ◽  
Vol 1 (6) ◽  
pp. 480-487 ◽  
Author(s):  
Ye Tian ◽  
Ranran Guo ◽  
Yunfeng Jiao ◽  
Yangfei Sun ◽  
Shun Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Disulfide Linkages ◽  
Targeting Delivery ◽  
Targeted Drug ◽  
Hollow Mesoporous Silica

Transferrin-capped hollow mesoporous silica nanoparticles through disulfide linkages realize tumor-targeting delivery and glutathione-induced drug release.

Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

2009 ◽  
Vol 20 (6) ◽  
pp. 1095-1099 ◽  
Author(s):  
Ling-Yan Tang ◽  
Yu-Cai Wang ◽  
Yang Li ◽  
Jin-Zhi Du ◽  
Jun Wang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Intracellular Drug Delivery

Biodegradable multiblock polyurethane micelles with tunable reduction-sensitivity for on-demand intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (47) ◽  
pp. 24736-24746 ◽  
Author(s):  
Xueling He ◽  
Mingming Ding ◽  
Jiehua Li ◽  
Hong Tan ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Cells ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages ◽  
Drug Delivery Applications

Biodegradable polyurethanes bearing varied amounts of disulfide linkages in the backbone can rapidly enter tumor cells and efficiently transport the encapsulated payloads into cytosol, resulting in controlled inhibition effects against cancer cells. The nanocarriers are promising candidates for on-demand intracellular drug delivery applications.

PEG-SS-PPS:  Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery

2007 ◽  
Vol 8 (6) ◽  
pp. 1966-1972 ◽  
Author(s):  
Simona Cerritelli ◽  
Diana Velluto ◽  
Jeffrey A. Hubbell
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Intracellular Drug Delivery

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

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