Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations

2019 ◽  
Vol 10 (22) ◽  
pp. 2840-2853 ◽  
Author(s):  
Arman Moini Jazani ◽  
Newsha Arezi ◽  
Chaitra Shetty ◽  
Sung Hwa Hong ◽  
Haowen Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Acid Reduction

Dual acid/reduction-degradable block copolymer nanoassemblies both at core/corona interfaces and in micellar cores leading to synergistic and accelerated drug release for robust tumor-targeting intracellular drug delivery.

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

Disassembly and tumor-targeting drug delivery of reduction-responsive degradable block copolymer nanoassemblies

2019 ◽  
Vol 10 (13) ◽  
pp. 1554-1568 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages

Review on recent strategies to synthesize novel disulfide-containing reductively-degradable block copolymers and their nanoassemblies as being classified with the number, position, and location of the disulfide linkages toward effective tumor-targeting intracellular drug delivery exhibiting enhanced release of encapsulated drugs.

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

2009 ◽  
Vol 20 (6) ◽  
pp. 1095-1099 ◽  
Author(s):  
Ling-Yan Tang ◽  
Yu-Cai Wang ◽  
Yang Li ◽  
Jin-Zhi Du ◽  
Jun Wang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Intracellular Drug Delivery

PEG-SS-PPS:  Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery

2007 ◽  
Vol 8 (6) ◽  
pp. 1966-1972 ◽  
Author(s):  
Simona Cerritelli ◽  
Diana Velluto ◽  
Jeffrey A. Hubbell
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Intracellular Drug Delivery

scholarly journals Drug Delivery: Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release (Adv. Mater. 3/2018)

2018 ◽  
Vol 30 (3) ◽  
pp. 1870020 ◽  
Author(s):  
Xing Guo ◽  
Lin Wang ◽  
Kayla Duval ◽  
Jing Fan ◽  
Shaobing Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles

Lipid Nanocapsules for Intracellular Drug Delivery of Anticancer Drugs

2007 ◽  
Vol 7 (12) ◽  
pp. 4612-4617 ◽  
Author(s):  
Franck Lacoeuille ◽  
Emmanuel Garcion ◽  
Jean-Pierre Benoit ◽  
Alf Lamprecht
Keyword(s):  
Drug Delivery ◽  
Cell Culture ◽  
Drug Release ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Release Kinetics ◽  
Laser Scanning Microscopy ◽  
Lipid Nanocapsules ◽  
Intracellular Drug Delivery ◽  
Drug Concentrations

As non-phagocytic eukaryotic cells can internalize particles <1 μm in size, small size (25 to 110 nm) lipid nanocapsules (LNC) are proposed for the intracellular drug delivery of anticancer drugs to cancer cells. LNC ofdifferent diameters were loaded with etoposide or paclitaxel and subsequently tested for drug release kinetics and their efficiency to reduce cancer cell growth in cell culture. Relative high drug loads could be achieved and sustained drug release can be provided over a period ofseveral days (etoposide) up to a few weeks (paclitaxel). While particle size exhibited only minor influences on the release kinetics, higher initial drug load led to a distinctly lower burst release. In a cancer cell culture model, etoposide or paclitaxel LNC showed a 4-fold or 40-fold higher efficiency, respectively than the drug solution while blank LNC were found to be less toxic than the pure drug at equivalent concentrations. The uptake and intracellular accumulation ofLNC was confirmed by confocal laser scanning microscopy after fluorescence labeling of the nanocarriers. This nanoparticulate system is able to achieve efficient intracellular drug concentrations and seems to be therefore a promising therapeutic approach in cancer treatment.

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