Total synthesis of giffonin H by fluoride-catalyzed macrocyclization
Keyword(s):
First total synthesis of giffonin H, a highly strained 15-membered macrocyclic diaryl ether, has been achieved. Key steps include Ullmann cross coupling, (Z)-selective Julia–Kocienski olefination, and fluoride-mediated macrocyclization of TMS-alkyne and aldehyde. The strategy used for macrocyclization is an unprecedented and unique synthetic approach for cyclic diarylheptanoids.
2013 ◽
Vol 9
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pp. 1346-1351
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2018 ◽
2019 ◽
Vol 16
(12)
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pp. 931-934
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2014 ◽
Vol 55
(31)
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pp. 4295-4297
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2010 ◽
Vol 65
(4)
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pp. 445-451
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