A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy

A novel delivery system for cisplatin based on electrostatics-mediated assemblies of gold nanoclusters and PEGylated cationic peptide was constructed. The constructed cisplatin@GC-pKs showed much enhanced anti-tumor activity for lung cancer therapy.

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Mutational analysis of a dominant oncogene (c-Ki-ras-2) and a tumor suppressor gene (p53) in hamster lung tumorigenesis

Molecular Carcinogenesis ◽

10.1002/mc.2940060305 ◽

1992 ◽

Vol 6 (3) ◽

pp. 199-202 ◽

Cited By ~ 11

Author(s):

Victor I. C. Oreffo ◽

Hsiu-Wei Lin ◽

Paul H. Gumerlock ◽

Susan A. Kraegel ◽

Hanspeter Witschi

Keyword(s):

Tumor Suppressor ◽

Tumor Suppressor Gene ◽

Mutational Analysis ◽

Suppressor Gene ◽

Lung Tumorigenesis ◽

Tumor Suppressor Gene P53

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Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy

ACS Applied Materials & Interfaces ◽

10.1021/acsami.7b10408 ◽

2017 ◽

Vol 9 (37) ◽

pp. 31600-31611 ◽

Cited By ~ 34

Author(s):

Fatemeh Mottaghitalab ◽

Melika Kiani ◽

Mehdi Farokhi ◽

Subhas C. Kundu ◽

Rui L. Reis ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Therapy ◽

Silk Fibroin ◽

Delivery System ◽

Targeted Delivery ◽

Silk Fibroin Nanoparticles ◽

Lung Cancer Therapy ◽

Targeted Delivery System

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Gene Therapy Clinical Trials for Cancer: Replacement of Tumor Suppressor Gene p53

Gene Therapy ◽

10.1201/9781420002126-45 ◽

2000 ◽

pp. 761-770

Keyword(s):

Gene Therapy ◽

Clinical Trials ◽

Tumor Suppressor ◽

Tumor Suppressor Gene ◽

Suppressor Gene ◽

Tumor Suppressor Gene P53

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Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

Vojnosanitetski pregled ◽

10.2298/vsp0201029t ◽

2002 ◽

Vol 59 (1) ◽

pp. 29-32 ◽

Cited By ~ 1

Author(s):

Brano Topic ◽

Nebojsa Stankovic ◽

Dragutin Savjak ◽

Slavko Grbic

Keyword(s):

Prognostic Factors ◽

Breast Carcinoma ◽

Tumor Suppressor ◽

Tumor Suppressor Gene ◽

Tumor Size ◽

Primary Tumor ◽

Suppressor Gene ◽

Nodal Status ◽

Primary Tumor Size ◽

Tumor Suppressor Gene P53

Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.

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