Wheat germ agglutinin modified magnetic iron oxide nanocomplex as a cell membrane specific receptor target material for killing breast cancer cells

2018 ◽  
Vol 6 (36) ◽  
pp. 5729-5737 ◽  
Author(s):  
Aekta Upadhyay ◽  
Ravinder Kandi ◽  
Chebrolu Pulla Rao
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Wheat Germ Agglutinin ◽  
Breast Cancer Cells ◽  
Wheat Germ ◽  
Target Material ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
A Cell

The magnetic iron oxide nanoparticles were coated with a fluorescent torch and were further tagged with wheat germ agglutinin so as to direct the resulting nanocomplex selectively towards breast cancer cells in order to deliver the drug.

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

scholarly journals Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells

Bioimpacts ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 117-127 ◽  
Author(s):  
Ayuob Aghanejad ◽  
Hiwa Babamiri ◽  
Khosro Adibkia ◽  
Jaleh Barar ◽  
Yadollah Omidi
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mucin 1

LHRH-conjugated Magnetic Iron Oxide Nanoparticles for Detection of Breast Cancer Metastases

2006 ◽  
Vol 99 (2) ◽  
pp. 163-176 ◽  
Author(s):  
Carola Leuschner ◽  
Challa SSR Kumar ◽  
William Hansel ◽  
Wole Soboyejo ◽  
Jikou Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Breast Cancer Metastases ◽  
Cancer Metastases

scholarly journals Gold-coated iron oxide nanoparticles as a potential photothermal therapy agent to enhance eradication of breast cancer cells

2020 ◽  
Vol 1497 ◽  
pp. 012003 ◽  
Author(s):  
M A Dheyab ◽  
A A Aziz ◽  
M S Jameel ◽  
P M Khaniabadi ◽  
B Mehrdel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Photothermal Therapy ◽  
Breast Cancer Cells ◽  
Oxide Nanoparticles

Methotrexate-conjugated L-lysine coated iron oxide magnetic nanoparticles for inhibition of MCF-7 breast cancer cells

2017 ◽  
Vol 44 (6) ◽  
pp. 886-894 ◽  
Author(s):  
Hamed Nosrati ◽  
Marziyeh Salehiabar ◽  
Soodabeh Davaran ◽  
Hossein Danafar ◽  
Hamidreza Kheiri Manjili
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Mcf 7

scholarly journals Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells

2018 ◽  
Vol 11 (04) ◽  
pp. 1850018 ◽  
Author(s):  
Yingyi Liu ◽  
Siyi Hu ◽  
Yueshu Feng ◽  
Peng Zou ◽  
Yue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Drug Carrier ◽  
Scratch Test ◽  
Inhibitory Effect ◽  
Inhibition Rate ◽  
Carrier System ◽  
A Cell ◽  
Drug Carrier System

In this paper, we prepared the nanoparticle drug carrier system between nanoparticles — chitosan and Epigallocatechin-3-O-gallate (EGCG) for breast cancer cell inhibiting application. For this drug carrier system, chitosan acts as a carrier and EGCG as a drug. Which were systematically characterized and thoroughly evaluated in terms of their inhibition rate and biocompatibility. We also did a cell scratch test and the result indicated that the chitosan-EGCG nanoparticles have inhibitory effect on the growth of breast cancer cells. The inhibition rate could reach up to 21.91%. This work revealed that the modification of nanoparticles paved a way for specific biomedical applications.

A Cell Penetrating Peptide, MTS-AR8, for Transfection of 4T1 Murine Breast Cancer Cells

2017 ◽  
Vol 7 (1) ◽  
pp. 62-68
Author(s):  
Preeti Sangave ◽  
Archana Upadhya
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

scholarly journals A Cell-Permeant Amiloride Derivative Induces Caspase-Independent, AIF-Mediated Programmed Necrotic Death of Breast Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e63038 ◽  
Author(s):  
Leonardo J. Leon ◽  
Nagarekha Pasupuleti ◽  
Fredric Gorin ◽  
Kermit L. Carraway
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
A Cell
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