Rational design of Fe3O4@C nanoparticles for simultaneous bimodal imaging and chemo-photothermal therapy in vitro and in vivo

2018 ◽  
Vol 6 (34) ◽  
pp. 5443-5450 ◽  
Author(s):  
Qinghe Han ◽  
Xiaodong Wang ◽  
Zhiqiang Sun ◽  
Xiaofei Xu ◽  
Longhai Jin ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Rational Design ◽  
Photoacoustic Imaging ◽  
Shell Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Bimodal Imaging ◽  
Delivery Vehicles ◽  
Core Shell Nanoparticles

A simple and novel synthetic route was developed to fabricate multifunctional Fe3O4@C eccentric core–shell nanoparticles as synergetic pH/NIR-responsive drug delivery vehicles for simultaneous biomodal magnetic resonance/photoacoustic imaging and synergistic photothermal cancer therapy in vitro.

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

scholarly journals Catalytic Core-Shell Nanoparticles With Self-Supplied Calcium And H2O2 To Enable Combinational Tumor Inhibition

2021 ◽  
Author(s):  
Chao Fang ◽  
Hanjing Kong ◽  
Qiang Chu ◽  
Zefeng Hu ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Ros Generation ◽  
Tumor Treatment ◽  
Shell Nanoparticles ◽  
Catalytic Core ◽  
Tumor Inhibition ◽  
Fenton Catalyst ◽  
Core Shell Nanoparticles

Abstract Nanoparticles, presenting catalytic activity to induce intracellular oxidative species, have been extensively explored for tumor treatment, but suffer daunting challenges in the limited intracellular H2O2 and thus suppressed therapeutic efficacy. Here in this study, a type of composite nanoparticles, consisting CaO2 core and Co-ferrocene shell, is designed and synthesized for combinational tumor treatment. The findings indicate that CaO2 core can be hydrolyzed to produce large amounts of H2O2 and calcium ions at the acidic tumor sites. Meanwhile, Co-ferrocene shell acts as an excellent Fenton catalyst, inducing considerable ROS generation following its reaction with H2O2. Excessive cellular oxidative stress triggers agitated calcium accumulation in addition to the calcium ions released from the particles. The combined effect of intracellular ROS and calcium overload causes significant tumor inhibition both in vitro and in vivo.

scholarly journals Pillar[5]arene-Modified Gold Nanorods as Nanocarriers for Multi-Modal Imaging-Guided Synergistic Photodynamic-Photothermal Therapy

2020 ◽  
Author(s):  
Nan Song ◽  
Zhijun Zhang ◽  
Peiying Liu ◽  
Dihua Dai ◽  
Chao Chen ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
High Performance ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Functional Materials ◽  
Ros Generation ◽  
Cancer Therapies ◽  
New Strategy

Supramolecular approaches have opened up vast possibilities in the construction of versatile functional materials, especially those with stimuli-responsiveness and integrated functionalities of multi-modal diagnosis and synergistic therapeutics. In this study, a hybrid theranostic nanosystem named TTPY-PyÌCP5@AuNR is constructed via facile host-guest interactions, where TTPY-Py is a photosensitizer with aggregation-induced emission and CP5@AuNR represents the carboxylatopillar[5]arene (CP5)-modified Au nanorods. TTPY-PyÌCP5@AuNR integrates the respective advantages of TTPY-Py and CP5@AuNR such as the high performance of reactive oxygen species (ROS) generation and photothermal conversion, and meanwhile shows fluorescence responses to both temperature and pH stimuli due to the non-covalent interactions. The successful modification of CP5 macrocycles on AuNRs surfaces can eliminate the cytotoxicity of AuNRs and enable them to serve as the nanocarrier of TTPY-Py for further theranostic application. Significantly, both in vitro and in vivo evaluations demonstrate that this supramolecular nanotheranostic system possesses multiple phototheranostic modalities including intensive fluorescence imaging (FLI), photoacoustic imaging (PAI), efficient photodynamic therapy (PDT), and photothermal therapy (PTT), indicating its great potentials for FLI-PAI imaging-guided synergistic PDT-PTT therapy. Besides, TTPY-Py can be released from the nanocarriers upon activating by the acidic environment of lysosomes and then specifically light up mitochondria. This study brings up a new strategy into the design of versatile nanotheranostics for accurate tumor imaging and cancer therapies.

scholarly journals An in vitro and in vivo bio-interaction responses and biosafety evaluation of novel Au–ZnTe core–shell nanoparticles

2016 ◽  
Vol 5 (4) ◽  
pp. 1078-1089 ◽  
Author(s):  
R. Dunpall ◽  
N. Revaprasadu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapeutics ◽  
Surface Modifications ◽  
Core Shell ◽  
Support Surface ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Biosafety Evaluation

Novel gold–zinc telluride (Au–ZnTe) core–shell nanoparticles were synthesized to support surface modifications for enhanced drug delivery in cancer therapeutics.

ZnO@Gd2O3 core/shell nanoparticles for biomedical applications: Physicochemical, in vitro and in vivo characterization

2017 ◽  
Vol 80 ◽  
pp. 603-615 ◽  
Author(s):  
Anna Woźniak ◽  
Bartosz F. Grześkowiak ◽  
Nataliya Babayevska ◽  
Tomasz Zalewski ◽  
Monika Drobna ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
In Vivo Characterization

Imaging of gold dendrimer nanocomposites in cells

2001 ◽  
Vol 676 ◽  
Author(s):  
Jonathan D. Eichman ◽  
Mohamed K. Khan ◽  
Inhan Lee ◽  
James R. Baker ◽  
Theodore S. Lawrence ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Radioactive Isotopes ◽  
Hybrid Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Tumor Microvasculature ◽  
Active Nanoparticles ◽  
Delivery Vehicles ◽  
Small Clusters

ABSTRACTDendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendrimer matrices. They have a great potential in biomedical applications due to their controlled composition, predetermined size, shape and surface functionalities. In this work, nanocomposites of gold and poly(amidoamine) dendrimers {Au(0)n-PAMAM} have been selected to demonstrate this nanoparticle based concept. {Au(0)n-PAMAM} gold dendrimer nanocomposites with a well-defined size have been synthesized and imaged by TEM both in vitro and in vivo. Dendrimer nanocomposites have also the potential to be used as drug delivery vehicles either utilizing bioactive guests or incorporating radioactive isotopes. Radioactive dendrimer nanocomposites, e.g. {198-Au}, can be delivered to the tumor either by means of injecting the active nanoparticles directly into the tumor microvasculature or by intravenous injection. Both specific or non-specific targeting can be utilized in this process to achieve appropriate transfer.

Isoniazid loaded core shell nanoparticles derived from PLGA–PEG–PLGA tri-block copolymers: In vitro and in vivo drug release

2013 ◽  
Vol 104 ◽  
pp. 107-115 ◽  
Author(s):  
Mani Gajendiran ◽  
Venkatachalam Gopi ◽  
Vellaichamy Elangovan ◽  
Rajagopalan Venkatakrishna Murali ◽  
Sengottuvelan Balasubramanian
Keyword(s):  
Block Copolymers ◽  
Drug Release ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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