scholarly journals A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides

2020 ◽  
Vol 56 (19) ◽  
pp. 2917-2920 ◽  
Author(s):  
Yuteng Wu ◽  
Alessandro Zorzi ◽  
Jack Williams ◽  
Christian Heinis
Keyword(s):  
Peptide Synthesis ◽  
Macrocyclic Compound ◽  
Short Peptides ◽  
Chromatographic Purification ◽  
Purification Step ◽  
Compound Libraries ◽  
Peptide Tag

A peptide synthesis and purification strategy that omits a throughput-limiting chromatographic purification step offers access to large macrocyclic compound libraries.

scholarly journals Preparation and Validated Analysis of Anthocyanin Concentrate from the Calyces of Hibiscus sabdariffa

2017 ◽  
Vol 12 (1) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Lubomir Opletal ◽  
Lucie Chocholousova-Havlikova ◽  
Tomas Siatka ◽  
Lucie Cahliková ◽  
Miroslav Locarek ◽  
...  
Keyword(s):  
Analytical Method ◽  
Anthocyanin Content ◽  
Hibiscus Sabdariffa ◽  
Chromatographic Purification ◽  
Purification Step ◽  
Extraction And Purification ◽  
Medicinal Properties ◽  
The Individual ◽  
Method Of Extraction ◽  
Column Chromatographic

Extracts of Hibiscus sabdariffa calyces have been shown to have various medicinal properties, some of which have been reported to be due to anthocyanins present in the calyces. To study whether these claims are valid, it is necessary to produce an extract with a high anthocyanin content and to have available a method to identify and quantify the individual compounds in the product. A method of extraction and purification has been developed based on a polyamide column chromatographic purification step. Using this method, anthocyanin concentrates were produced containing from 57 to 64% of delphinidin-3-sambubioside plus cyanidin-3-sambubioside. A rapid, efficient and validated HPLC analytical method was developed and used for the analysis of the anthocyanin concentrate.

scholarly journals Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK

2016 ◽  
Vol 14 (37) ◽  
pp. 8659-8663 ◽  
Author(s):  
Ryan A. Davis ◽  
Kevin Lau ◽  
Sven H. Hausner ◽  
Julie L. Sutcliffe
Keyword(s):  
Peptide Synthesis ◽  
High Purity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Continuous Process ◽  
Solid Support ◽  
Purification Step ◽  
Phase Synthesis

A rapid, efficient single continuous process for peptide synthesis, cyclization, and radiolabeling on solid-support with a single purification step afforded a high purity radiotracer.

Picomole‐scale synthesis and screening of macrocyclic compound libraries by acoustic liquid transfer

2021 ◽  
Author(s):  
Gontran Sangouard ◽  
Alessandro Zorzi ◽  
Yuteng Wu ◽  
Edouard Ehret ◽  
Mischa Schüttel ◽  
...  
Keyword(s):  
Macrocyclic Compound ◽  
Compound Libraries ◽  
Liquid Transfer

Picomole‐scale synthesis and screening of macrocyclic compound libraries by acoustic liquid transfer

2021 ◽  
Author(s):  
Gontran Sangouard ◽  
Alessandro Zorzi ◽  
Yuteng Wu ◽  
Edouard Ehret ◽  
Mischa Schüttel ◽  
...  
Keyword(s):  
Macrocyclic Compound ◽  
Compound Libraries ◽  
Liquid Transfer

A two-hour synthesis of anti-Parkinson drug Safinamide Methanesulfonate

Synlett ◽  
2021 ◽  
Author(s):  
Vanessa Mayumi Higa ◽  
Alvaro Takeo Omori
Keyword(s):  
Microwave Irradiation ◽  
Ethyl Acetate ◽  
Real Time ◽  
Therapeutic Agents ◽  
Biologically Active ◽  
Green Solvents ◽  
Free Base ◽  
Chromatographic Purification ◽  
Purification Step ◽  
One Pot

The critical moment of COVID-19 outbreak requires a real time supply of therapeutic agents. Thus, the time economy in the synthesis of biologically active compounds has been increasingly decisive. In this work, we have developed a two-hour synthesis of anti-Parkinson drug safinamide methanesulfonate in 4 steps, with 64% overall yield. Microwave irradiation was used in the first three steps in a one-pot fashion. In fact, this presented protocol can provide Safinamide free base in one hour without chromatographic purification step. Also, green solvents such as methanol and ethyl acetate were applied.

scholarly journals Synthesis of 11-(Piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine on Kilo Scale

2011 ◽  
Vol 8 (4) ◽  
pp. 1747-1749 ◽  
Author(s):  
Rahul S. Kalhapure ◽  
Bhushan P. Patil ◽  
Mahantesh N. Jadhav ◽  
Laxmikant A. Kawle ◽  
Sanjay B. Wagh
Keyword(s):  
Catalytic Hydrogenation ◽  
Chromatographic Purification ◽  
Purification Step ◽  
Key Steps

A synthesis of 11-(piperazin-1yl)-5 H-dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.

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