Why hydroxy-proline improves the catalytic power of the peptidoglycan N-deacetylase enzyme: insight from theory

2019 ◽  
Vol 21 (42) ◽  
pp. 23338-23345 ◽  
Author(s):  
Mario Prejanò ◽  
Isabella Romeo ◽  
Luigi Sgrizzi ◽  
Nino Russo ◽  
Tiziana Marino
Keyword(s):  
Transition State ◽  
Energy Demand ◽  
Related Energy ◽  
Hydroxy Proline ◽  
Bond Network ◽  
Catalytic Power

The OH moiety of 2Hyp establishes a larger H-bond network and an electrostatic environment that stabilizes the transition state, reducing the related energy demand.

Atomic Dissection of the Hydrogen Bond Network for Transition-State Analogue Binding to Purine Nucleoside Phosphorylase†

Biochemistry ◽  
2002 ◽  
Vol 41 (49) ◽  
pp. 14489-14498 ◽  
Author(s):  
Greg A. Kicska ◽  
Peter C. Tyler ◽  
Gary B. Evans ◽  
Richard H. Furneaux ◽  
Wuxian Shi ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Transition State ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Hydrogen Bond Network ◽  
Nucleoside Phosphorylase ◽  
Transition State Analogue ◽  
Bond Network

scholarly journals Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization

2010 ◽  
Vol 402 (1) ◽  
pp. 194-209 ◽  
Author(s):  
Andrea Hall ◽  
Derek Parsonage ◽  
Leslie B. Poole ◽  
P. Andrew Karplus
Keyword(s):  
Transition State ◽  
Transition State Stabilization ◽  
Catalytic Power

Rating Mass-related Energy Demand for Vehicles with New Powertrain Concepts

2011 ◽  
Vol 4 (2) ◽  
pp. 2603-2607 ◽  
Author(s):  
Matthias Horn ◽  
Jens Neubeck ◽  
Jochen Wiedemann
Keyword(s):  
Energy Demand ◽  
Related Energy

Exergy analysis of building thermal load and related energy flows in buildings

2015 ◽  
Vol 26 (9) ◽  
pp. 1257-1273 ◽  
Author(s):  
Tianhe Han ◽  
Yue Zheng ◽  
Guangcai Gong
Keyword(s):  
Thermal Load ◽  
Energy Demand ◽  
Exergy Analysis ◽  
Building Design ◽  
Thermal Design ◽  
Exergy Loss ◽  
Analysis Method ◽  
Climate Zones ◽  
Related Energy ◽  
Energy Flows

In this study, the exergy analysis method was extended to analyse the building thermal load and related energy flows, aiming to investigate the exergy loss as well as improvement potential for building design and analysis. Five office buildings in five major climate zones in China were taken as case studies for the analysis. The building thermal loads and related energy flows were calculated and analysed using the exergy analysis method. Results show that the building exergy load is relatively low compared to the building thermal energy load. However, it is always met by consuming energy of high exergy value (e.g. electricity), indicating the exergy mismatch between the energy demand and supply. The latent exergy load cannot be disregarded for building thermal load and energy flows analysis, especially for buildings in humid climate. Large exergy loss, which is dominated by solar gain, was found in all five reference buildings across different climate zones. This study provides a comprehensive understanding of building thermal load and related energy flows, and would benefit building evaluation and thermal design of building envelop.

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