scholarly journals Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis

RSC Advances ◽  
2019 ◽  
Vol 9 (24) ◽  
pp. 13855-13862 ◽  
Author(s):  
Changyue Wu ◽  
Yifan Wu ◽  
Yang Jin ◽  
Piaoyu Zhu ◽  
Weiwei Shi ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles ◽  
Ormosil Nanoparticles

Organically modified silica (ORMOSIL) nanoparticles (NPs) are widely used in biomedicine.

Development of organically modified silica nanoparticles for monitoring the intracellular level of oxygen using a frequency-domain FLIM platform

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36938-36947 ◽  
Author(s):  
Barbara Korzeniowska ◽  
Marcel Raspe ◽  
Dorota Wencel ◽  
Robert Woolley ◽  
Kees Jalink ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Frequency Domain ◽  
Oxygen Concentration ◽  
Dynamic Quenching ◽  
Intracellular Level ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles ◽  
Ormosil Nanoparticles

The dynamic quenching of luminescence derived from Ru(dpp3)2+-doped ORMOSIL nanoparticles is used for monitoring of the intracellular oxygen concentration.

scholarly journals Organically Modified Silica Nanoparticles Are Biocompatible and Can Be Targeted to Neurons In Vivo

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29424 ◽  
Author(s):  
Farda Barandeh ◽  
Phuong-Lan Nguyen ◽  
Rajiv Kumar ◽  
Gary J. Iacobucci ◽  
Michelle L. Kuznicki ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

Organically modified silica nanoparticles as drug delivery vehicles in photodynamic therapy

2011 ◽  
Vol 15 (05n06) ◽  
pp. 401-411 ◽  
Author(s):  
Anurag Gupta ◽  
Lalit N. Goswami ◽  
Manivannan Ethirajan ◽  
Joseph Missert ◽  
K.V.R. Rao ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Encapsulation Efficiency ◽  
Release Kinetics ◽  
Alkyl Ether ◽  
Modified Silica ◽  
Drug Delivery Vehicles ◽  
Organically Modified ◽  
Delivery Vehicles ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

To investigate the effect of hydrophobicity, charge and size of photosensitizers (PS) on their encapsulation efficiency in organically modified silica nanoparticles (ORMOSIL), a series of alkyl ether analogs of 2-(1′-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) containing varied number of carbon units, HPPH with anionic and cationic functionalities, and HPPH analogs with molecular weight ranging from ~630 to 6000 Daltons were synthesized. Our preliminary results suggest that these factors play a significant role in encapsulation of the photosensitizers and their release from ORMOSIL nanoparticles. The synthesis and characterization of PS-encapsulated ORMOSIL and a comparative study on the effect of PS size, lipophilicity and charge on encapsulation efficiency, photophysical characteristics and release kinetics are discussed.

Covalently Dye-Linked, Surface-Controlled, and Bioconjugated Organically Modified Silica Nanoparticles as Targeted Probes for Optical Imaging

ACS Nano ◽  
2008 ◽  
Vol 2 (3) ◽  
pp. 449-456 ◽  
Author(s):  
Rajiv Kumar ◽  
Indrajit Roy ◽  
Tymish Y. Ohulchanskyy ◽  
Lalit N. Goswami ◽  
Adela C. Bonoiu ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles
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