scholarly journals Inhibition of metal-induced amyloid β-peptide aggregation by a blood–brain barrier permeable silica–cyclen nanochelator

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14126-14131 ◽  
Author(s):  
Jinzhuan Wang ◽  
Kun Wang ◽  
Zhenzhu Zhu ◽  
Yafeng He ◽  
Changli Zhang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Blood Brain

A BBB-passable nanoscale silica–cyclen chelator effectively reduces the metal-induced Aβ aggregates and related ROS, thereby decreasing the neurotoxicity of Aβ.

P4-069: Modeling amyloid β-peptide transport across the blood-brain barrier in TR-BBB cells

2006 ◽  
Vol 2 ◽  
pp. S533-S534
Author(s):  
Kaoru Yamada ◽  
Chiori Yabuki ◽  
Masanori Tachikawa ◽  
Sumio Ohtsuki ◽  
Dudley K. Strickland ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Peptide Transport ◽  
Amyloid Β Peptide ◽  
Blood Brain

scholarly journals Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Agnès Dodacki ◽  
Matthew Wortman ◽  
Bruno Saubaméa ◽  
Stéphanie Chasseigneaux ◽  
Sophie Nicolic ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Mouse Blood ◽  
Blood Brain ◽  
And Function ◽  
The Brain

Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions

2002 ◽  
Vol 38 (6) ◽  
pp. 303-313 ◽  
Author(s):  
Jasmina B Mackic ◽  
James Bading ◽  
Jorge Ghiso ◽  
Larry Walker ◽  
Thomas Wisniewski ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Blood Brain

scholarly journals 1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier

2011 ◽  
Vol 8 (1) ◽  
pp. 20 ◽  
Author(s):  
Shingo Ito ◽  
Sumio Ohtsuki ◽  
Yasuko Nezu ◽  
Yusuke Koitabashi ◽  
Sho Murata ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Mouse Brain ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Dihydroxyvitamin D3 ◽  
Blood Brain

scholarly journals Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood-brain barrier using focused ultrasound

2021 ◽  
Author(s):  
Ramon Vilar ◽  
Tiffany G Chan ◽  
Carmen Ruehl ◽  
Sophie Morse ◽  
Michelle Simon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metal Complexes ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Amyloid Β ◽  
Binding Mode ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Blood Brain

One of the key hallmarks of Alzheimer’s disease is the aggregation of the amyloid-β peptide to form fibrils. Consequently, there has been great interest in studying molecules that can disrupt...

Oatp1a4 and an L-Thyroxine-Sensitive Transporter Mediate the Mouse Blood-Brain Barrier Transport of Amyloid-β Peptide

2013 ◽  
Vol 36 (3) ◽  
pp. 555-561 ◽  
Author(s):  
Tuan Minh Do ◽  
Beatrice Bedussi ◽  
Stéphanie Chasseigneaux ◽  
Agnès Dodacki ◽  
Cédric Yapo ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Mouse Blood ◽  
Blood Brain
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