Grape seed proanthocyanidin extract ameliorates dextran sulfate sodium-induced colitis through intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokines and gut microbiota modulation

2020 ◽  
Vol 11 (9) ◽  
pp. 7817-7829 ◽  
Author(s):  
Kangliang Sheng ◽  
Guanghui Zhang ◽  
Ming Sun ◽  
Shiman He ◽  
Xiaowei Kong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Stress Reduction ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Barrier ◽  
Grape Seed ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin ◽  
And Oxidative Stress

Grape seed proanthocyanidin extract had the strongest efficacy on colitis through inhibiting inflammation and oxidative stress, protecting epithelial integrity, and gut microbiota modulation.

Desmethylbellidifolin Attenuates Dextran Sulfate Sodium-Induced Colitis: Impact on Intestinal Barrier, Intestinal Inflammation and Gut Microbiota

Planta Medica ◽  
2021 ◽  
Author(s):  
Jiaqi Wu ◽  
Yuzheng Wu ◽  
Yue Chen ◽  
Mengyang Liu ◽  
Haiyang Yu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Inflammation ◽  
Activity Index ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Function Evaluation ◽  
Biological Drugs

AbstractUlcerative colitis has been recognized as a chronic inflammatory disease predominantly disturbing the colon and rectum. Clinically, the aminosalicylates, steroids, immunosuppressants, and biological drugs are generally used for the treatment of ulcerative colitis at different stages of disease progression. However, the therapeutic efficacy of these drugs does not satisfy the patients due to the frequent drug resistance. Herein, we reported the anti-ulcerative colitis activity of desmethylbellidifolin, a xanthone isolated from Gentianella acuta, in dextran sulfate sodium-induced colitis in mice. C57BL/6 mice were treated with 2% dextran sulfate sodium in drinking water to induce acute colitis. Desmethylbellidifolin or balsalazide sodium was orally administrated once a day. Biological samples were collected for immunohistological analysis, intestinal barrier function evaluation, cytokine measurement, and gut microbiota analysis. The results revealed that desmethylbellidifolin alleviated colon shortening and body weight loss in dextran sulfate sodium-induced mice. The disease activity index was also lowered by desmethylbellidifolin after 9 days of treatment. Furthermore, desmethylbellidifolin remarkably ameliorated colonic inflammation through suppressing the expression of interleukin-6 and tumor necrosis factor-α. The intestinal epithelial barrier was strengthened by desmethylbellidifolin through increasing levels of occludin, ZO-1, and claudins. In addition, desmethylbellidifolin modulated the gut dysbiosis induced by dextran sulfate sodium. These findings suggested that desmethylbellidifolin effectively improved experimental ulcerative colitis, at least partly, through maintaining intestinal barrier integrity, inhibiting proinflammatory cytokines, and modulating dysregulated gut microbiota.

Dietary intake of Lycium ruthenicum Murray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis

2020 ◽  
Vol 11 (4) ◽  
pp. 2924-2937
Author(s):  
Shuai Zong ◽  
Liu Yang ◽  
Hyun Jin Park ◽  
Jinglei Li
Keyword(s):  
Inflammatory Cell ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Barrier ◽  
Ethanol Extract ◽  
Experimental Colitis ◽  
Lycium Ruthenicum ◽  
Intestinal Barrier Integrity ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

Lycium ruthenicum Murray extract protected experimental colitis by inhibiting pro-inflammatory cytokines production, inflammatory cell infiltration, inflammatory mediators activation and oxidative stress, and restored intestinal barrier integrity.

scholarly journals Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Xingting Liu ◽  
Xin Lin ◽  
Yuling Mi ◽  
Jian Li ◽  
Caiqiao Zhang
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Chromatin Condensation ◽  
Natural Aging ◽  
Grape Seed ◽  
Protective Effects ◽  
Ovarian Aging ◽  
Grape Seed Proanthocyanidin Extract ◽  
Age Related ◽  
Grape Seed Proanthocyanidin

Oxidative stress is an important inducement in ovarian aging which results in fecundity decline in human and diverse animals. As a potent antioxidant, grape seed proanthocyanidin extract (GSPE) was investigated to ameliorate chicken ovarian aging in this study. Firstly, ovarian antioxidant capacity of hens at different ages (90, 150, 280, and 580 days old) was compared to elucidate its age-related changes. Subsequently, a D-gal-induced (2.5 mg/mL) aging ovarian model was established and the cultured ovarian tissues were treated with GSPE at 5 μg/mL for 72 h to evaluate the putative attenuating effects of GSPE on ovarian aging. Meanwhile, ovaries of D280 (young) and D580 (old) were treated with GSPE for 72 h in culture to verify the protective effects of GSPE on natural aging ovary. The results showed that GSPE could rescue the antioxidant capacity decline by increasing the antioxidase activities and their gene expression in either D-gal-induced or natural aging ovaries. Moreover, GSPE could maintain the homeostasis between cell proliferation and apoptosis in the D-gal-induced and natural aging ovaries, as well as alleviate D-gal-induced nucleus chromatin condensation in the ovarian granulosa cells. In conclusion, GSPE treatment can effectively prevent the ovarian aging process in hens by reducing oxidative stress.

Preventive effect of carob (Ceratonia siliqua L.) in dextran sulfate sodium-induced ulcerative colitis in rat

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 19992-20000 ◽  
Author(s):  
Kaïs Rtibi ◽  
Mohamed-Amine Jabri ◽  
Slimen Selmi ◽  
Hichem Sebai ◽  
Jean-Claude Marie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Gastrointestinal Diseases ◽  
Common Mechanism ◽  
Ceratonia Siliqua ◽  
Preventive Effect ◽  
Ceratonia Siliqua L ◽  
And Oxidative Stress

Inflammation and oxidative stress are a common mechanism of many gastrointestinal diseases such ulcerative colitis.

Protection of Primary Glial Cells by Grape Seed Proanthocyanidin Extract against Nitrosative/ Oxidative Stress

Nitric Oxide ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 137-149 ◽  
Author(s):  
Sanjoy Roychowdhury ◽  
Gerald Wolf ◽  
Gerburg Keilhoff ◽  
Debasis Bagchi ◽  
Thomas Horn
Keyword(s):  
Oxidative Stress ◽  
Glial Cells ◽  
Grape Seed ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin
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