Dietary intake of Lycium ruthenicum Murray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis

2020 ◽  
Vol 11 (4) ◽  
pp. 2924-2937
Author(s):  
Shuai Zong ◽  
Liu Yang ◽  
Hyun Jin Park ◽  
Jinglei Li
Keyword(s):  
Inflammatory Cell ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Barrier ◽  
Ethanol Extract ◽  
Experimental Colitis ◽  
Lycium Ruthenicum ◽  
Intestinal Barrier Integrity ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

Lycium ruthenicum Murray extract protected experimental colitis by inhibiting pro-inflammatory cytokines production, inflammatory cell infiltration, inflammatory mediators activation and oxidative stress, and restored intestinal barrier integrity.

Grape seed proanthocyanidin extract ameliorates dextran sulfate sodium-induced colitis through intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokines and gut microbiota modulation

2020 ◽  
Vol 11 (9) ◽  
pp. 7817-7829 ◽  
Author(s):  
Kangliang Sheng ◽  
Guanghui Zhang ◽  
Ming Sun ◽  
Shiman He ◽  
Xiaowei Kong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Stress Reduction ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Barrier ◽  
Grape Seed ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin ◽  
And Oxidative Stress

Grape seed proanthocyanidin extract had the strongest efficacy on colitis through inhibiting inflammation and oxidative stress, protecting epithelial integrity, and gut microbiota modulation.

scholarly journals Anti-Colitic Effects of Ethanol Extract of Persea americana Mill. through Suppression of Pro-Inflammatory Mediators via NF-κB/STAT3 Inactivation in Dextran Sulfate Sodium-Induced Colitis Mice

2019 ◽  
Vol 20 (1) ◽  
pp. 177 ◽  
Author(s):  
Joo Young Hong ◽  
Kyung-Sook Chung ◽  
Ji-Sun Shin ◽  
Geonha Park ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Molecular Mechanisms ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Clinical Signs ◽  
Ethanol Extract ◽  
Persea Americana ◽  
Expression Levels ◽  
Cox 2 ◽  
Pro Inflammatory Cytokines

Persea americana Mill, cv. Hass, also known as avocado, has been reported to possess hypolipidemic, anti-diabetic, anti-oxidant, cardioprotective, and photoprotective potencies. However, few studies have reported its anti-colitic effects. In this study, we investigated anti-colitic effects of ethanol extract of P. americana (EEP) in dextran sulfate sodium (DSS)-induced colitic mice and the involved molecular mechanisms. EEP effectively improved clinical signs and histological characteristics of DSS-induced colitis mice. In DSS-exposed colonic tissues, EEP reduced expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines such as interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α. Moreover, EEP suppressed DSS-induced activation of nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3). Consistent with in vivo results, EEP also suppressed protein and mRNA expression levels of iNOS, COX-2, and pro-inflammatory cytokines via NF-κB and STAT3 inactivation in LPS-induced RAW 264.7 macrophages. Taken together, our data indicate that ethanol extract of avocado may be used as a promising therapeutic against inflammatory bowel diseases by suppressing the NF-κB and STAT3 signaling pathway.

scholarly journals Intestinal mesenchymal cells regulate immune responses and promote epithelial regeneration in vitro and in dextran sulfate sodium‐induced experimental colitis in mice

2021 ◽  
Author(s):  
Laura Hidalgo‐Garcia ◽  
José Alberto Molina‐Tijeras ◽  
Francisco Huertas‐Peña ◽  
Antonio Jesús Ruiz‐Malagón ◽  
Patricia Diez‐Echave ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Experimental Colitis ◽  
Mesenchymal Cells ◽  
Epithelial Regeneration ◽  
Regeneration In Vitro

Involvement of CD4+ T Cells in the Development of Dextran Sulfate Sodium-Induced Experimental Colitis and Suppressive Effect of IgG on Their Action

1998 ◽  
Vol 31 (3) ◽  
pp. 477-481 ◽  
Author(s):  
Nahoko Shintani ◽  
Tsunetaka Nakajima ◽  
Tadao Okamoto ◽  
Takao Kondo ◽  
Norifumi Nakamura ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Experimental Colitis ◽  
Suppressive Effect
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