scholarly journals Oxidative Stress Is Involved In The Activation of NF-κB Signal Pathway And Immune Inflammatory Response In Grass Carp Gill Induced By Cypermethrin And/Or Sulfamethoxazole Exposure

2021 ◽  
Author(s):  
Baoying Li ◽  
Yu Wang ◽  
Hongjing Zhao ◽  
Kai Yin ◽  
Yachen Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Environmental Pollutants ◽  
Nuclear Factor Κb ◽  
Signal Pathway ◽  
Toxic Effects ◽  
Stress Index ◽  
Separate Analysis ◽  
Fish Gills

Abstract At present, the concentration of environmental pollutants, such as pesticides and antibiotics exposed in environment, especially in aquatic environment is increasing. These contaminants are exposed through aquatic environment to fish and ultimately accumulate in humans. Research on environmental pollutants has exploded in the past two years. However, there are still few studies on the combined effects of pesticides and antibiotics on fish, especially on fish gills. A separate analysis of the toxic effects caused by an environmental pollutant cannot fully show the real situation. In this paper, cypermethrin (CMN) and sulfamethoxazole (SMZ) were analyzed and found that there was a strong correlation between the pathways affected by the first 30 genes regulated by CMN and SMZ respectively. Therefore, the toxic effects of CMN (0.651 μg/L) and/or SMZ (0.3 μg/L) on grass carp gill were studied in this paper. Histopathology, quantitative real-time PCR and other methods were used to detect the tissue morphology, oxidative stress level, inflammation and apoptosis-related indicators of the fish gills after exposure 42 days. It was found that compared with the single exposure (SMZ/CMN) group, the combined exposure (MIX) group had a more pronounced oxidative stress index imbalance. At the same time, nuclear factor-κB (NF-κB) signal pathway was activated and immuno-inflammatory reaction appeared in MIX group. This study reveals the harm of CMN and SMZ to fish, and provides a reference and basis for the rational use of pesticides and antibiotics.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

scholarly journals Chromium(VI) Toxicity in Legume Plants: Modulation Effects of Rhizobial Symbiosis

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Uliana Ya. Stambulska ◽  
Maria M. Bayliak ◽  
Volodymyr I. Lushchak
Keyword(s):  
Oxidative Stress ◽  
Plant Biomass ◽  
Environmental Pollutants ◽  
Toxic Effects ◽  
Pigment Synthesis ◽  
Chromium Vi ◽  
Rhizobial Symbiosis ◽  
Promote Plant Growth ◽  
Legume Plants ◽  
Cellular Components

Most legume species have the ability to establish a symbiotic relationship with soil nitrogen-fixing rhizobacteria that promote plant growth and productivity. There is an increasing evidence of reactive oxygen species (ROS) important role in formation of legume-rhizobium symbiosis and nodule functioning. Environmental pollutants such as chromium compounds can cause damage to rhizobia, legumes, and their symbiosis. In plants, toxic effects of chromium(VI) compounds are associated with the increased production of ROS and oxidative stress development as well as with inhibition of pigment synthesis and modification of virtually all cellular components. These metabolic changes result in inhibition of seed germination and seedling development as well as reduction of plant biomass and crop yield. However, if plants establish symbiosis with rhizobia, heavy metals are accumulated preferentially in nodules decreasing the toxicity of metals to the host plant. This review summarizes data on toxic effects of chromium on legume plants and legume-rhizobium symbiosis. In addition, we discussed the role of oxidative stress in both chromium toxicity and formation of rhizobial symbiosis and use of nodule bacteria for minimizing toxic effects of chromium on plants.

scholarly journals The Effects of Apitherapeutic Agents on Oxidative Stress in Serum Metabolic Parameters of Hypertensive Rats Created by Nitric Oxide Synthase Inhibited

2021 ◽  
Vol 50 (6) ◽  
pp. 1745-1754
Author(s):  
Mehmet Fuat Gulhan ◽  
Betul Ozdemir ◽  
Zeliha Selamoglu ◽  
Engin Sahna
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Total Antioxidant Status ◽  
Nuclear Factor Κb ◽  
Treated Group ◽  
Caffeic Acid Phenethyl Ester ◽  
Stress Index ◽  
Clinical Effects ◽  
Hypertensive Rats ◽  
Protein Levels

Hypertension is a chronic disease affecting the whole world due to its clinical effects and complications. The reduction in the release and effect of NO is one of the mechanisms of hypertension formation. Hypertension disrupts the balance between oxidant and antioxidant mechanisms. In this study, we aimed to observe biochemical changes in the blood by treatment propolis, caffeic acid phenethyl ester (CAPE) and pollen in hypertensive rats via Nω-Nitro-L-arginine methyl ester (L-NAME). Rats were divided in five groups. Rats were given L-NAME (40 mg/kg, intraperitoneally) for 14 days to make hypertensive. L-NAME and bee products were administered together with rats for 14 days, then L-NAME for 14 days. All administrated ended 28 days. There was a statistically significant (P<0.05) decrease in blood pressure (BP) in the groups in which bee products were applied. Blood pressure was lower in the pollen treated group than in the CAPE and propolis treated group (P<0.05). Paraoxanase (PON1), total antioxidant status (TAS), total oxidant status (TOS), asymmetric dimethylarginine (ADMA), nuclear factor-κB (NF-κB) levels were measured in the blood samples in all groups. In the L-NAME group; PON1, TAS, HDL, and total protein levels were found to be lower than the groups applied bee products (P<0.05). TOS, oxidative stress index (OSI), ADMA, NF-κB, glucose, cholesterol, LDL, triglyceride, ALT, AST, ALP levels were found to be lower in groups plus of bee products were applied compared to the group that received L-NAME (P<0.05). The results showed that oxidative stress and homeostasis can be regulated with propolis, CAPE and pollen in hypertensive rats induced L-NAME.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

scholarly journals Understanding the role of oxidative stress in the incidence of metabolic syndrome and obstructive sleep apnea

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Behnam Kargar ◽  
Zahra Zamanian ◽  
Majid Bagheri Hosseinabadi ◽  
Vahid Gharibi ◽  
Mohammad Sanyar Moradi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Logistic Regression ◽  
Sleep Apnea ◽  
International Diabetes Federation ◽  
Binary Logistic Regression ◽  
Stress Index ◽  
Obstructive Sleep

Abstract Background Understanding the causes and risk factors of metabolic syndrome is important for promoting population health. Oxidative stress has been associated with metabolic syndrome, and also obstructive sleep apnea. These are two diseases which have common prognostic characteristics for heart disease. The aim of this study was to examine the role of oxidative stress in the concurrent presence of metabolic syndrome and obstructive sleep apnea in a working population. Methods Participants were 163 artisan bakers in Shahroud, Iran, routinely exposed to significant heat stress and other oxidative stress indicators on a daily basis as part of their work. Using a cross-sectional design, data relevant to determining metabolic syndrome status according to International Diabetes Federation criteria, and the presence of obstructive sleep apnea according to the STOP-Bang score, was collected. Analyses included hierarchical binary logistic regression to yield predictors of the two diseases. Results Hierarchical binary logistic regression showed that oxidative stress – alongside obesity, no regular exercise, and smoking – was an independent predictor of metabolic syndrome, but not obstructive sleep apnea. Participants who were obese were 28 times more likely to have metabolic syndrome (OR 28.59, 95% CI 4.91–63.02) and 44 times more likely to have obstructive sleep apnea (OR 44.48, 95% CI 4.91–403.28). Participants meeting metabolic syndrome criteria had significantly higher levels of malondialdehyde (p <  0.05) than those who did not. No difference in oxidative stress index levels were found according to obstructive sleep apnea status. Conclusions Our findings suggest that oxidative stress contributes to the onset of metabolic syndrome, and that obstructive sleep apnea is involved in oxidative stress. Whilst obesity, exercise, and smoking remain important targets for reducing the incidence of metabolic syndrome and obstructive sleep apnea, policies to control risks of prolonged exposure to oxidative stress are also relevant in occupations where such environmental conditions exist.

scholarly journals Total Antioxidant Capacity and Lipid Peroxidation Status in Cervical Cancer Patients Compared with Women Without Cervical Cancer in Bangladesh

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
Taslima Nigar ◽  
Annekathryn Goodman ◽  
Shahana Pervin
Keyword(s):  
Oxidative Stress ◽  
Cervical Cancer ◽  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Antioxidant Capacity ◽  
Cancer Patients ◽  
Total Antioxidant Capacity ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Total Antioxidant

Abstract Purpose Over the past several decades, research has suggested reactive oxygen species act as cofactors for cervical cancer development. The aim of this study is to evaluate the antioxidant and lipid peroxidation status in cervical cancer patients in Bangladesh. Methods From December 2017 to 2018, a cross-sectional observational study was conducted on 50 cervical cancer patients and 50 controls. Plasma levels of lipid peroxidation and total antioxidant capacity were measured. The Student’s t test was used for statistical analysis. P values less than 0.05 were taken as a level of significance. Results There was a significant reduction in total antioxidant levels in patients with cervical cancer, 972.77 ± 244.22 SD µmol equivalent to ascorbic acid/L, compared to normal controls, 1720.13 ± 150.81 SD µmol equivalent to ascorbic acid/L (P < 0.001). Levels of lipid peroxidation were found to be significantly higher in cervical cancer, 7.49 ± 2.13 SD µmol/L, than in women without cervical cancer, 3.28 ± 0.58 SD µmol/L (P < 0.001). The cervical cancer patients had significantly higher levels of oxidative stress index (0.83 ± 0.31) in comparison to controls (0.19 ± 0.04) (P < 0.001). Conclusion There was an increased oxidative stress index due to imbalance between lipid peroxidation generation and total antioxidant capacity in cervical cancer patients. Further studies are needed to explore the role of oxidative stress as a cofactor for cervical carcinogenesis.

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