Germinated millet flour (Pennisetum Glaucum (L.) R. BR.) improves adipogenesis and glucose metabolism and maintains thyroid function in vivo

2021 ◽  
Author(s):  
Jaqueline Maciel Vieira Theodoro ◽  
Oscar David Medina Martinez ◽  
Mariana Grancieri ◽  
Renata Celi Lopes Toledo ◽  
Mirella Lima Binoti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Thyroid Function ◽  
Wistar Rats ◽  
Pennisetum Glaucum ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose

This study investigated the effects of germinated millet flour on adipogenesis, insulin resistance, glucose tolerance and thyroid function in Wistar rats fed with a high-fat high-fructose diet (HFHF). The experiment...

Kombuchas from green and black teas reduce oxidative stress, liver steatosis and inflammation, and improve glucose metabolism in Wistar rats fed a high-fat high-fructose diet

2021 ◽  
Author(s):  
Rodrigo Cardoso ◽  
Luiza Dias Moreira ◽  
Mirian Costa ◽  
Renata Celi Lopes Toledo ◽  
Mariana Grancieri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Glucose Metabolism ◽  
Wistar Rats ◽  
Liver Steatosis ◽  
Black Tea ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose ◽  
Green And Black Tea

The aim of this study was to evaluate the effect of green and black tea kombuchas consumption on adiposity, lipid metabolism, liver steatosis, oxidative stress, and inflammation in Wistar rats...

scholarly journals Effect of extracts from selected Kenyan plants on traits of metabolic syndrom in Wistar rats fed a high-fat high fructose diet

2020 ◽  
Vol 19 (10) ◽  
pp. 2137-2146
Author(s):  
Beatrice N. Kiage-Mokua ◽  
Michael De Vrese ◽  
Ina Kraus-Stojanowic ◽  
Annegret Nielsen ◽  
Patrick Kareru ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Traditional Medicine ◽  
Pancreatic Lipase ◽  
Wistar Rats ◽  
Aqueous Extracts ◽  
High Fat ◽  
High Fructose Diet ◽  
Glucosidase Activity ◽  
High Fructose ◽  
Ethanol Extracts

Purpose: To examine the potential of extracts from selected herbs used in African traditional medicine in diabetes patients, and to determine their effect on traits of metabolic syndrome in rats fed a high-fat and high-fructose diet.Methods: Ethanol and aqueous extracts were prepared from Mangifera indica (MI), Lonchocarpus eriocalyx (LE), Urtica massaica (UM), Schkuhria pinnata (SP) and Launaea cornuta (LC). Ethanol extracts (1:100 dilution) were examined for inhibition of pancreatic lipase and α-glucosidase activity invitro. Furthermore, aqueous extracts were administered for 74 days to male Wistar rats fed a high-fat and high-fructose diet to assess their effect on traits of metabolic syndrome.Results: Ethanol extracts showed at least 30 % inhibition of pancreatic lipase in vitro but no effect on α- glucosidase activity. Administration of the aqueous extracts caused significant reduction in liver triglycerides (except for LE). Muscle triglycerides and fat were also reduced, with the most pronounced effect elicited by LE. Urinary glucose excretion and plasma triglycerides, but not hyperinsulinemia and insulin resistance, were reduced by UM compared to control.Conclusion: This exploratory study indicates that UM may be considered a candidate for the prevention and management of type 2 diabetes. Keywords: Kenyan traditional medicine, High-fat diet, High fructose, Insulin resistance, Triglycerides, Diabetes, Liver steatosis

Dry heated whole sorghum flour (BRS 305) with high tannin and resistant starch improves glucose metabolism, modulates adiposity, and reduces liver steatosis and lipogenesis in Wistar rats fed with a high-fat high-fructose diet

2021 ◽  
Vol 99 ◽  
pp. 103201
Author(s):  
Oscar David Medina Martinez ◽  
Jaqueline Maciel Vieira Theodoro ◽  
Mariana Grancieri ◽  
Renata Celi Lopes Toledo ◽  
Valéria Aparecida Vieira Queiroz ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Resistant Starch ◽  
Wistar Rats ◽  
Liver Steatosis ◽  
High Fat ◽  
High Fructose Diet ◽  
Sorghum Flour ◽  
High Fructose

Sea cucumbers-derived sterol sulfate alleviates insulin resistance and inflammation in high-fat-high-fructose diet-induced obese mice

2020 ◽  
Vol 160 ◽  
pp. 105191
Author(s):  
Hui-Juan Zhang ◽  
Cheng Chen ◽  
Lin Ding ◽  
Hao-Hao Shi ◽  
Cheng-Cheng Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obese Mice ◽  
High Fat ◽  
Sea Cucumbers ◽  
High Fructose Diet ◽  
High Fructose

Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive ratThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.

2007 ◽  
Vol 85 (3-4) ◽  
pp. 422-429 ◽  
Author(s):  
Jihong Jiang ◽  
Linda Tran ◽  
Harish Vasudevan ◽  
Zhengyuan Xia ◽  
Violet G. Yuen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Control Level ◽  
Total Duration ◽  
Endothelin 1 ◽  
High Fructose Diet ◽  
Thromboxane Synthase Inhibitor ◽  
High Fructose ◽  
Male Wistar Rats ◽  
Synthase Inhibitor

Feeding rats with a high fructose diet results in insulin resistance and hypertension. Fructose-hypertensive rats (FHR) have increased vascular levels of endothelin-1 (ET-1) and thromboxane (TXA2). We have previously shown that chronic treatment with either the dual endothelin receptor blocker, bosentan, or the thromboxane synthase inhibitor, dazmegrel, prevented fructose-induced increases in blood pressure, suggesting that both ET-1 and TXA2 play important roles in the development of hyperinsulinemia/insulin resistance-associated hypertension. In this study, we investigated the potential interrelationship between ET-1 and TXA2 in the development of fructose-induced hypertension in vivo. Male Wistar rats were fed on a high fructose diet for 9 weeks. Either bosentan or dazmegrel treatment (daily by oral gavage) was initiated 3 weeks after the start of fructose feeding for a total duration of 6 weeks. At the end of drug treatment, blood and aorta were collected from each animal. Plasma thromboxane B2 (TXB2), a stable TXA2 metabolite, increased significantly in FHR and was reduced to control level by both chronic bosentan and dazmegrel treatment. Protein expression of cyclooxygenase 2 (COX2) was elevated significantly in FHR aortas and treatment with bosentan and dazmegrel corrected these changes. These results indicate that the actions of ET-1 in the aorta of FHR may be mediated through COX2-derived TXA2. Bosentan may prevent the development of hypertension in fructose-fed rats through inhibition of COX2 induction and subsequently the reduction in plasma TXA2.

scholarly journals Insulin resistance induced by post-weaning high fructose diet in Wistar rats: reversal by metformin

1994 ◽  
Vol 34 (6) ◽  
pp. 629-630
Author(s):  
S. Halimi ◽  
E. Rossini ◽  
PY Benhamou ◽  
P. Faure ◽  
P. André
Keyword(s):  
Insulin Resistance ◽  
Wistar Rats ◽  
High Fructose Diet ◽  
High Fructose

Abstract 3512: Disruption of Whole Nitric Oxide Synthase System Causes Impaired Glucose Tolerance and Insulin Resistance in Mice in Vivo

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Sei Nakata ◽  
Masato Tsutsui ◽  
Hiroaki Shimokawa ◽  
Ken Sabanai ◽  
Yasuko Yatera ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Pancreatic Islets ◽  
Plasma Glucose ◽  
Insulin Levels

Background : Nitric oxide (NO) synthase (NOS) system consists of 3 different isoforms, including neuronal (nNOS), inducible (iNOS), and endothelial NOSs (eNOS). We have recently succeeded in developing mice lacking all NOS genes (triply n/i/eNOS-KO mice) ( PNAS 2005). Our preliminary study has revealed that the triply-KO mice develop acute myocardial infarction (AMI). The present study was designed to investigate abnormalities of glucose metabolism, an important risk factor of MI, in those mice. Methods and Results : Experiments were performed in 3-month-old male wild-type (WT) and triply-KO mice (n=5–7). At 15 minutes after intravenous glucose administration (1 g/kg), plasma glucose levels (mg/dl) were significantly higher in the triply-KO (475 ± 44) than in the WT mice (241 ± 20) ( P< 0.05), and plasma insulin levels (ng/dl) were significantly lower in the triply-KO (0.50 ± 0.03) than in the WT mice (0.78 ± 0.03) ( P< 0.05). In the triply-KO mice, the size of pancreatic islets (islet/pancreatic area, 0.64 ± 0.16 vs. 2.81 ± 0.64%) was significantly smaller ( P< 0.05), and significant apoptosis of pancreatic islets (apoptotic/total islets, 19 ± 2 vs. 3 ± 1%) (TUNEL staining) was noted as compared with the WT mice ( P< 0.05). Furthermore, insulin sensitivity (as assessed by insulin-induced [ 3 H]-glucose uptake in isolated soleus muscle) (fold increase) was markedly reduced in the triply-KO mice (1.1 ± 0.03) as compared with the WT mice (2.1 ± 0.3) ( P< 0.05), associated with an impairment of insulin-induced translocation of glucose transporter-4 (GLUT-4) to the cellular membrane (immunofluorescent staining) ( P< 0.05). Importantly, supplementation of NO by long-term treatment with isosorbide dinitrate (0.4 mg/day, 6 weeks, dermal application) significantly reversed all these abnormalities of glucose metabolism in the triply-KO mice; plasma glucose (280 ± 28) and insulin levels (0.89 ± 0.10) after glucose tolerance test, insulin sensitivity (1.5 ± 0.08), and GLUT-4 translocation were all improved (all P< 0.05). Conclusions : These results indicate that disruption of whole NOSs system causes impaired glucose tolerance and insulin resistance in mice in vivo, suggesting a critical role of endogenous NO/NOSs system in maintaining glucose metabolism.

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