Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents

2021 ◽  
Author(s):  
Leilei Huang ◽  
Jinwen Huang ◽  
Hui Nie ◽  
Yingzi Li ◽  
Lixing Song ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

A series of combretastatin A-4 (CA-4) sulfamate derivatives were synthesized and their structure–activity relationship on tubulin, arylsulfatase and tumor cell antiproliferation inhibition was studied.

Design, synthesis and biological evaluation of novel peptide MC2 analogues from Momordica charantia as potential anti-diabetic agents

2015 ◽  
Vol 13 (15) ◽  
pp. 4551-4561 ◽  
Author(s):  
Baowei Yang ◽  
Xue Li ◽  
Chenyu Zhang ◽  
Sijia Yan ◽  
Wei Wei ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Momordica Charantia ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Oxidative Effects ◽  
Relationship Of ◽  
Synthesis And Biological Evaluation

The structure–activity relationship of peptide MC2 resulted in the development of compoundIII-3, which exhibited potent anti-hyperglycaemic and anti-oxidative effects.

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