scholarly journals Design, Synthesis, And Biological Evaluation of G Protein‐Coupled Estrogen Receptor (GPR30/GPER) Ligands That Contribute to The First Structure‐Activity‐Relationship for The Receptor

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Chelsea Sondergard ◽  
Christopher Arnatt
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
G Protein Coupled ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel peptide MC2 analogues from Momordica charantia as potential anti-diabetic agents

2015 ◽  
Vol 13 (15) ◽  
pp. 4551-4561 ◽  
Author(s):  
Baowei Yang ◽  
Xue Li ◽  
Chenyu Zhang ◽  
Sijia Yan ◽  
Wei Wei ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Momordica Charantia ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Oxidative Effects ◽  
Relationship Of ◽  
Synthesis And Biological Evaluation

The structure–activity relationship of peptide MC2 resulted in the development of compoundIII-3, which exhibited potent anti-hyperglycaemic and anti-oxidative effects.

Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents

2021 ◽  
Author(s):  
Leilei Huang ◽  
Jinwen Huang ◽  
Hui Nie ◽  
Yingzi Li ◽  
Lixing Song ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

A series of combretastatin A-4 (CA-4) sulfamate derivatives were synthesized and their structure–activity relationship on tubulin, arylsulfatase and tumor cell antiproliferation inhibition was studied.

Structure–activity relationship of novel macrocyclic biased apelin receptor agonists

2017 ◽  
Vol 15 (2) ◽  
pp. 449-458 ◽  
Author(s):  
Alexandre Murza ◽  
Xavier Sainsily ◽  
Jérôme Côté ◽  
Laurent Bruneau-Cossette ◽  
Élie Besserer-Offroy ◽  
...  
Keyword(s):  
G Protein ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
G Protein Coupled Receptor ◽  
Endogenous Ligand ◽  
Structure Activity ◽  
Apelin Receptor ◽  
Relationship Of ◽  
G Protein Coupled ◽  
Cardiovascular Functions

Apelin is the endogenous ligand for the G protein-coupled receptor APJ and exerts a key role in regulating cardiovascular functions.

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