One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using deep eutectic solvent: A green method and mechanistic insight

2021 ◽  
Author(s):  
Phuong Hoang Tran ◽  
Vu Nguyen ◽  
Nguyen Truong Truong Hai
Keyword(s):  
Low Temperatures ◽  
Deep Eutectic Solvent ◽  
Multicomponent Synthesis ◽  
Green Method ◽  
One Pot ◽  
Mechanistic Insight ◽  
Amidoalkyl Naphthols

The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl2]3). The reactions proceed smoothly at low temperatures for...

scholarly journals Correction: One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: a green method and mechanistic insight

2021 ◽  
Vol 45 (9) ◽  
pp. 4507-4507
Author(s):  
Vu Thanh Nguyen ◽  
Hai Truong Nguyen ◽  
Phuong Hoang Tran
Keyword(s):  
Deep Eutectic Solvent ◽  
Green Method ◽  
One Pot ◽  
Mechanistic Insight ◽  
Amidoalkyl Naphthols

Correction for ‘One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: a green method and mechanistic insight’ by Vu Thanh Nguyen et al., New J. Chem., 2021, 45, 2053–2059, DOI: 10.1039/d0nj05687a.

scholarly journals One-pot multicomponent synthesis of thieno[2,3-b]indoles catalyzed by a magnetic nanoparticle-supported [Urea]4[ZnCl2] deep eutectic solvent

RSC Advances ◽  
2020 ◽  
Vol 10 (16) ◽  
pp. 9663-9671 ◽  
Author(s):  
The Thai Nguyen ◽  
Phuong Hoang Tran
Keyword(s):  
Multicomponent Reaction ◽  
Magnetic Nanoparticle ◽  
Deep Eutectic Solvent ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Green Catalyst

We have developed the synthesis of thieno[2,3-b]indole dyes via a multicomponent reaction of cheap and available reagents using a magnetic nanoparticle-supported [Urea]4[ZnCl2] deep eutectic solvent as a green catalyst.

Rapid and Efficient One-Pot Multicomponent Synthesis of Pyrano[3,2-c]chromene Derivatives, Catalyzed by a Deep Eutectic Solvent

2021 ◽  
Vol 57 (8) ◽  
pp. 1321-1329
Author(s):  
S. Tasqeeruddin ◽  
Y. I. Asiri ◽  
S. Shaheen
Keyword(s):  
Deep Eutectic Solvent ◽  
Multicomponent Synthesis ◽  
One Pot

One-pot synthesis of 4H-pyrano[3,2-c]coumarin derivatives catalyzed by deep eutectic solvent

Synthesis ◽  
2021 ◽  
Author(s):  
Zong-Bo Xie ◽  
Hong-Xia Li ◽  
Jiang-Nan Yang ◽  
Xiao Zhu ◽  
Zhang-Gao Le
Keyword(s):  
Deep Eutectic Solvent ◽  
Aromatic Aldehydes ◽  
Pharmaceutical Compounds ◽  
Single Step ◽  
Molar Ratio ◽  
Coumarin Derivatives ◽  
Reaction Conditions ◽  
Green Method ◽  
One Pot ◽  
High Yields

4H-Pyrano[3,2-c]coumarin derivatives are an important class of pharmaceutical compounds that are expensive to prepare by previously reported methods. An efficient and green method was developed to obtain these derivatives using the deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. An aromatic aldehyde, 4-hydroxycoumarin, and cyanoacetate were used as the substrates. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.

One Pot Multicomponent Synthesis of Tetrahydrobenzo[b] pyrans and Dihydropyrano[c] chromenes using Magnetically Separable NiFe2O4 Nanoparticles

2018 ◽  
Vol 8 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Karthik K. Krishnan ◽  
Vijay V. Dabholkar ◽  
Ajay Gopinathan ◽  
Rahul Jaiswar
Keyword(s):  
Multicomponent Synthesis ◽  
One Pot ◽  
Nife2o4 Nanoparticles ◽  
Magnetically Separable

Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

2017 ◽  
Vol 3 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Sunetra Jadhav ◽  
Ajinkya Patravale ◽  
Reshma Patil ◽  
Digambar Kumbhar ◽  
Vishram Karande ◽  
...  
Keyword(s):  
Sulfamic Acid ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Acid Catalyzed

scholarly journals Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3279
Author(s):  
Ilma Nugrahani ◽  
Maria Anabella Jessica
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Strong Interactions ◽  
Green Method ◽  
Pharmaceutical Ingredients ◽  
Gastrointestinal Fluid ◽  
Non Covalent Interactions ◽  
Natural Deep Eutectic Solvent ◽  
Covalent Interactions

Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API’s physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API’s solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.

scholarly journals Clean one-pot multicomponent synthesis of pyrans using a green and magnetically recyclable heterogeneous nanocatalyst

SynOpen ◽  
2021 ◽  
Author(s):  
Mina Ghassemi ◽  
Ali Maleki
Keyword(s):  
Room Temperature ◽  
Significant Loss ◽  
Copper Ferrite ◽  
Multicomponent Synthesis ◽  
Thermo Gravimetric ◽  
Sem Images ◽  
One Pot ◽  
Three Component Reaction ◽  
Ft Ir ◽  
The One

Copper ferrite (CuFe2O4) magnetic nanoparticles (MNPs) were synthesized via thermal decomposition method and applied as a reusable and green catalyst in the synthesis of functionalized 4H-pyran derivatives using malononitrile, an aromatic aldehyde and a β-ketoester in ethanol at room temperature. Then it was characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX) analysis, scanning electron microscopy (SEM) images, thermo gravimetric and differential thermo gravimetric (TGA/DTG) analysis. The catalyst was recovered from the reaction mixture by applying an external magnet and decanting the mixture. Recycled catalyst was reused for several times without significant loss in its activity. Running the one-pot three-component reaction at room temperature, no use of eternal energy source and using a green solvent provide benign, mild, and environmentally friendly reaction conditions; as well, ease of catalyst recovering, catalyst recyclability, no use of column chromatography and good to excellent yields are extra advantages of this work.

Deep eutectic solvent mediated rapid and selective one-pot synthesis of 5-alkylidene-Thiazolones

2021 ◽  
Vol 22 ◽  
pp. 100457
Author(s):  
Najmedin Azizi ◽  
Mahnaz Qomi ◽  
Malihe Asghari ◽  
Elham Farhadi
Keyword(s):  
Deep Eutectic Solvent ◽  
One Pot ◽  
One Pot Synthesis
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