scholarly journals Correction: One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: a green method and mechanistic insight

2021 ◽  
Vol 45 (9) ◽  
pp. 4507-4507
Author(s):  
Vu Thanh Nguyen ◽  
Hai Truong Nguyen ◽  
Phuong Hoang Tran
Keyword(s):  
Deep Eutectic Solvent ◽  
Green Method ◽  
One Pot ◽  
Mechanistic Insight ◽  
Amidoalkyl Naphthols

Correction for ‘One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: a green method and mechanistic insight’ by Vu Thanh Nguyen et al., New J. Chem., 2021, 45, 2053–2059, DOI: 10.1039/d0nj05687a.

One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using deep eutectic solvent: A green method and mechanistic insight

2021 ◽  
Author(s):  
Phuong Hoang Tran ◽  
Vu Nguyen ◽  
Nguyen Truong Truong Hai
Keyword(s):  
Low Temperatures ◽  
Deep Eutectic Solvent ◽  
Multicomponent Synthesis ◽  
Green Method ◽  
One Pot ◽  
Mechanistic Insight ◽  
Amidoalkyl Naphthols

The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl2]3). The reactions proceed smoothly at low temperatures for...

One-pot synthesis of 4H-pyrano[3,2-c]coumarin derivatives catalyzed by deep eutectic solvent

Synthesis ◽  
2021 ◽  
Author(s):  
Zong-Bo Xie ◽  
Hong-Xia Li ◽  
Jiang-Nan Yang ◽  
Xiao Zhu ◽  
Zhang-Gao Le
Keyword(s):  
Deep Eutectic Solvent ◽  
Aromatic Aldehydes ◽  
Pharmaceutical Compounds ◽  
Single Step ◽  
Molar Ratio ◽  
Coumarin Derivatives ◽  
Reaction Conditions ◽  
Green Method ◽  
One Pot ◽  
High Yields

4H-Pyrano[3,2-c]coumarin derivatives are an important class of pharmaceutical compounds that are expensive to prepare by previously reported methods. An efficient and green method was developed to obtain these derivatives using the deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. An aromatic aldehyde, 4-hydroxycoumarin, and cyanoacetate were used as the substrates. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.

scholarly journals Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3279
Author(s):  
Ilma Nugrahani ◽  
Maria Anabella Jessica
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Strong Interactions ◽  
Green Method ◽  
Pharmaceutical Ingredients ◽  
Gastrointestinal Fluid ◽  
Non Covalent Interactions ◽  
Natural Deep Eutectic Solvent ◽  
Covalent Interactions

Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API’s physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API’s solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.

Deep eutectic solvent mediated rapid and selective one-pot synthesis of 5-alkylidene-Thiazolones

2021 ◽  
Vol 22 ◽  
pp. 100457
Author(s):  
Najmedin Azizi ◽  
Mahnaz Qomi ◽  
Malihe Asghari ◽  
Elham Farhadi
Keyword(s):  
Deep Eutectic Solvent ◽  
One Pot ◽  
One Pot Synthesis

ChemInform Abstract: One-Pot Synthesis of Polysubstituted Imidazoles in a Broensted Acidic Deep Eutectic Solvent.

ChemInform ◽  
2013 ◽  
Vol 44 (39) ◽  
pp. no-no
Author(s):  
Liang Wang ◽  
Xia Zhong ◽  
Min Zhou ◽  
Wei-you Zhou ◽  
Qun Chen ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
One Pot ◽  
One Pot Synthesis

Mechanistic insight of in situ electrochemical reduction of solid PbO to lead in ChCl-EG deep eutectic solvent

2015 ◽  
Vol 186 ◽  
pp. 455-464 ◽  
Author(s):  
Juanjian Ru ◽  
Yixin Hua ◽  
Ding Wang ◽  
Cunying Xu ◽  
Jian Li ◽  
...  
Keyword(s):  
Electrochemical Reduction ◽  
Deep Eutectic Solvent ◽  
Mechanistic Insight

scholarly journals One-pot multi-component process for the synthesis of 4-azaphenanthrene-3,10-dione, 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives catalyzed by the deep eutectic solvent choline chloride-oxalic acid

2020 ◽  
Vol 75 (3) ◽  
pp. 269-279
Author(s):  
Mohammad Hosein Sayahi ◽  
Maryam Gorjizadeh ◽  
Melan Meheiseni ◽  
Soheil Sayyahi
Keyword(s):  
Oxalic Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Reaction Times ◽  
Eutectic Mixture ◽  
Reaction Yield ◽  
One Pot ◽  
Experimental Procedure ◽  
Component Process ◽  
High Yields

AbstractAn effective method based on choline chloride (ChCl)-oxalic acid (Ox) deep eutectic solvent was proposed for the synthesis of 4-azaphenanthrene-3,10-dione, 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives. The eutectic mixture worked as both the solvent and acidic catalyst for conversion. The impacts of different variables, including the composition and volume of ChCl-Ox, and temperature, on reaction yield were studied for optimization. The crucial advantages of this process are simplicity of the experimental procedure, high yields, short reaction times, high recyclability, and the use of safe and inexpensive components.

Sign in / Sign up

Export Citation Format

Share Document