scholarly journals Thrombo-tag, an in vivo formed nanotracer for the detection of thrombi in mice by fast pre-targeted molecular imaging

Nanoscale ◽  
2020 ◽  
Vol 12 (45) ◽  
pp. 22978-22987
Author(s):  
José M. Adrover ◽  
Juan Pellico ◽  
Irene Fernández-Barahona ◽  
Sandra Martín-Salamanca ◽  
Jesús Ruiz-Cabello ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Rapid Detection ◽  
Oxide Nanoparticles ◽  
The Brain ◽  
Targeted Molecular Imaging

68Ga-core doped iron oxide nanoparticles permit the rapid detection of thrombi in the brain by fast pretargeting imaging.

scholarly journals Cu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaging

ACS Omega ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 2719-2727 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
Lucía Gutiérrez ◽  
Sabino Veintemillas-Verdaguer ◽  
Juan Pellico ◽  
María del Puerto Morales ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
One Pot ◽  
One Pot Synthesis ◽  
Longitudinal Relaxivity ◽  
Targeted Molecular Imaging

scholarly journals Nonpolymeric Surface-Coated Iron Oxide Nanoparticles for In Vivo Molecular Imaging: Biodegradation, Biocompatibility, and Multiplatform

2013 ◽  
Vol 54 (11) ◽  
pp. 1974-1980 ◽  
Author(s):  
C.-M. Lee ◽  
S.-J. Cheong ◽  
E.-M. Kim ◽  
S. T. Lim ◽  
Y. Y. Jeong ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma

2017 ◽  
Vol 6 (5) ◽  
pp. 449-472 ◽  
Author(s):  
Marina Fontes de Paula Aguiar ◽  
Javier Bustamante Mamani ◽  
Taylla Klei Felix ◽  
Rafael Ferreira dos Reis ◽  
Helio Rodrigues da Silva ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Process Efficiency ◽  
Cochrane Library ◽  
Oxide Nanoparticles ◽  
Magnetic Targeting

AbstractThe purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by physicochemical characteristics of SPIONs used, cell types used for tumor induction, characteristics of experimental glioma models, magnetic targeting technical parameters, and analysis method of process efficiency. The study shows the highlights and importance of magnetic targeting to optimize the magnetic targeting process as a therapeutic strategy for gliomas. Regardless of the intensity of the patterned magnetic field, the time of application of the field, and nanoparticle used (commercial or synthesized), all studies showed a vast advantage in the use of magnetic targeting, either alone or in combination with other techniques, for optimized glioma therapy. Therefore, this review elucidates the preclinical and therapeutic applications of magnetic targeting in glioma, an innovative nanobiotechnological method.

A Review on Green Synthesis and Applications of Iron Oxide Nanoparticles

2021 ◽  
Vol 21 (12) ◽  
pp. 5812-5834
Author(s):  
Rachana Yadwade ◽  
Saili Kirtiwar ◽  
Balaprasad Ankamwar
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Aqueous System ◽  
Oxide Nanoparticles ◽  
Plant Parts ◽  
Different Types ◽  
Removal Of Heavy Metals ◽  
Biological Sources ◽  
Different Sources

Bio-fabrication of iron oxide nanoparticles by using different sources of plants, plant parts and microbial cells have become a great topic of interest nowadays due to its eco-friendly nature. The stabilizing and capping agents in biological sources are biocompatible, stable and non-toxic which make its use beneficial for various biomedical applications. The bacteria are able to utilize metal ions and convert them into their respective nanoparticles by secreting different biomolecules. The plants and plant parts contain different types of phytochemicals which play a key role in synthesis and bio-fabrication of nanoparticles. Iron oxide nanoparticles are known to have various applications in the fields of medicine, environment etc. This review summarizes the applications of iron oxide nanoparticles as antimicrobial agent, drug delivery agent, material for removal of heavy metals and dyes from aqueous system etc. Due to these wide applications of iron oxide nanoparticles its demand in various fields is increasing considerably. This review describes different approaches which are used for biosynthesis of iron oxide nanoparticles and their applications. The review also summarizes about the surface modification strategies of iron oxide nanoparticles by using different polymers, polyelectrolytes which can be used for in-vivo applications.

LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors

2016 ◽  
Vol 4 (3) ◽  
pp. 474-482 ◽  
Author(s):  
Ling Ding ◽  
Yong Hu ◽  
Yu Luo ◽  
Jianzhi Zhu ◽  
Yilun Wu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Coprecipitation Method ◽  
Oxide Nanoparticles

LAPONITE®-stabilized iron oxide nanoparticles with great colloidal stability and high T2 relaxivity are synthesized by a facile controlled coprecipitation method, and can significantly enhance the contrast of tumors in vivo, indicating their tremendous potential in MR imaging applications.

Efficient and Rapid Labeling of Transplanted Cell Populations with Superparamagnetic Iron Oxide Nanoparticles Using Cell Surface Chemical Biotinylation for in Vivo Monitoring by MRI

2010 ◽  
Vol 19 (4) ◽  
pp. 419-429 ◽  
Author(s):  
Po-Wah So ◽  
Tammy Kalber ◽  
David Hunt ◽  
Michael Farquharson ◽  
Alia Al-Ebraheem ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Tracking ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Cell Populations ◽  
Oxide Nanoparticles ◽  
Signal Loss

Determination of the dynamics of specific cell populations in vivo is essential for the development of cell-based therapies. For cell tracking by magnetic resonance imaging (MRI), cells need to internalize, or be surface labeled with a MRI contrast agent, such as superparamagnetic iron oxide nanoparticles (SPIOs): SPIOs give rise to signal loss by gradient-echo and T2-weighted MRI techniques. In this study, cancer cells were chemically tagged with biotin and then magnetically labeled with anti-biotin SPIOs. No significant detrimental effects on cell viability or death were observed following cell biotinylation. SPIO-labeled cells exhibited signal loss compared to non-SPIO-labeled cells by MRI in vitro. Consistent with the in vitro MRI data, signal attenuation was observed in vivo from SPIO-labeled cells injected into the muscle of the hind legs, or implanted subcutaneously into the flanks of mice, correlating with iron detection by histochemical and X-ray fluorescence (XRF) methods. To further validate this approach, human mesenchymal stem cells (hMSCs) were also employed. Chemical biotinylation and SPIO labeling of hMSCs were confirmed by fluorescence microscopy and flow cytometry. The procedure did not affect proliferation and multipotentiality, or lead to increased cell death. The SPIO-labeled hMSCs were shown to exhibit MRI signal reduction in vitro and was detectable in an in vivo model. In this study, we demonstrate a rapid, robust, and generic methodology that may be a useful and practical adjuvant to existing methods of cell labeling for in vivo monitoring by MRI. Further, we have shown the first application of XRF to provide iron maps to validate MRI data in SPIO-labeled cell tracking studies.

scholarly journals Non-Invasive Transdermal Delivery of Chemotherapeutic Molecules In Vivo Using Superparamagnetic Iron Oxide Nanoparticles

2021 ◽  
Author(s):  
Vanisri Raviraj ◽  
Binh T.T. Pham ◽  
Byung J. Kim ◽  
Nguyen T.H. Pham ◽  
Lai F. Kok ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Fluorescence Microscopy ◽  
Iron Oxide Nanoparticles ◽  
Transdermal Delivery ◽  
Immune Cell ◽  
Superparamagnetic Iron Oxide ◽  
Skin Penetration ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Abstract Background: The skin is both a target and a potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated the potential of superparamagnetic iron oxide nanoparticles to facilitate the transdermal delivery of anti-cancer agents.Results: Chemotherapeutic cancer drugs were applied with or without nanoparticles to the skin of hairless mice, and their ability to penetrate the skin was assessed using fluorescence microscopy and tumor growth. Nanoparticles enhanced the penetration of the skin by doxorubicin and 5-fluorouracil as determined by fluorescence microscopy and growth retardation of experimental melanoma in immunocompetent, syngeneic mice. This drug enhancement did not require conjugation or encapsulation of the drugs by the nanoparticles – simple co-administration sufficed. Nanoparticles applied topically to melanomas increased the cytotoxicity and immune cell infiltration induced by co-administered 5-fluorouracil, and also reduced vascularization of the tumors independently of 5-fluorouracil.Conclusion: Correctly formulated superparamagnetic iron oxide nanoparticles can facilitate the chemotherapeutic effectiveness of cytotoxic drugs on skin tumors by both increasing their transdermal penetration and ameliorating host-tumor interactions. This enhancement of skin penetration occurs without the need for conjugation or encapsulation of the co-administered drugs and so will likely be applicable to other drugs, also.

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