A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch

2020 ◽  
Vol 11 (12) ◽  
pp. 2194-2204 ◽  
Author(s):  
Bingjie Hao ◽  
Wei Li ◽  
Sen Zhang ◽  
Ying Zhu ◽  
Yongjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Smart Drug ◽  
Smart Drug Delivery

A novel nanographene oxide/PEG-based bioreduction-responsive smart drug delivery system with a GSH-responsive disulfide linker as the controlled release switch can selectively release anti-cancer drugs in cancer cells.

Glucose-Responsive Microspheres as a Smart Drug Delivery System for Controlled Release of Insulin

2019 ◽  
Vol 45 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Jiaojiao Yu ◽  
Qiongyan Wang ◽  
Haofan Liu ◽  
Xiaosong Shan ◽  
Ziyan Pang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Correction: Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17041-17041 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Receptor Targeting ◽  
Anti Cancer ◽  
Folate Receptor Targeting

Correction for ‘Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs’ by Xubo Zhao et al., RSC Adv., 2014, 4, 24232–24239.

Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24232-24239 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Ph Responsive ◽  
Anti Cancer ◽  
Folate Receptor Targeting

A novel graphene oxide (GO)-based nanocarrier has been designed for the targeting and pH-responsive controlled release of anti-cancer drugs.

Preparation of biodegradable PEGylated pH/reduction dual-stimuli responsive nanohydrogels for controlled release of an anti-cancer drug

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 12051-12060 ◽  
Author(s):  
Tingting Zhou ◽  
Xubo Zhao ◽  
Lei Liu ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Stimuli Sensitive

Monodisperse biodegradable PEGylated pH and reduction dual-stimuli sensitive PMPB nanohydrogels were prepared as a drug delivery system for controlled release anti-cancer drugs.

scholarly journals Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 588 ◽  
Author(s):  
Xia Li ◽  
Manpreet Sambi ◽  
Alexandria DeCarlo ◽  
Sergey V. Burov ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inner Core ◽  
Hydrophobic Drug ◽  
Alternating Copolymer ◽  
Smart Drug ◽  
Smart Drug Delivery

Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a “smart” drug delivery system to be specific for a tumour in vivo and to penetrate the inner core remains a major design challenge. These challenges can be overcome by using a study model that integrates the three-dimensional aspect of a tumour in a culture system. Here, we tested the efficacy of a functionalized folic acid-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA) to specifically target and penetrate the inner core of three-dimensional avascular human pancreatic and breast tumour spheroids in culture. The copolymer was quantitatively analyzed for its hydrophobic drug encapsulation efficiency using three different chemical drug structures with different molecular weights. Their release profiles and tumour targeting properties at various concentrations and pH environments were also characterized. Using the anticancer drug curcumin and two standard clinical chemotherapeutic hydrophobic drugs, paclitaxel and 5-fluorouracil, we tested the ability of FA-DABA-SMA nanoparticles to encapsulate the differently sized drugs and deliver them to kill monolayer pancreatic cancer cells using the WST-1 cell proliferation assay. The findings of this study revealed that the functionalized folic acid-conjugated amphiphilic alternating copolymer shows unique properties as an active “smart” tumor-targeting drug delivery system with the ability to internalize hydrophobic drugs and release the chemotherapeutics for effective killing of cancer cells. The novelty of the study is the first to demonstrate a functionalized “smart” drug delivery system encapsulated with a hydrophobic drug effectively targeting and penetrating the inner core of pancreatic and breast cancer spheroids and reducing their volumes in a dose- and time-dependent manner.

Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

2015 ◽  
Vol 51 (8) ◽  
pp. 1475-1478 ◽  
Author(s):  
Wang Xiao ◽  
Xuan Zeng ◽  
Hang Lin ◽  
Kai Han ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer

A dual stimuli-responsive multi-drug delivery system was developed for “cancer cocktail therapy”. Release behaviors of the dual drugs could be controlled separately by appropriate stimulation.

scholarly journals Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Changzhen Sun ◽  
Ji Lu ◽  
Jun Wang ◽  
Ping Hao ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject. Results To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells. Conclusions A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

scholarly journals Redox-Sensitive Polymeric Micelles with Aggregation-Induced Emission for Bioimaging and Delivery of Anticancer Drugs

2020 ◽  
Author(s):  
Changzhen Sun ◽  
Ji Lu ◽  
Jun Wang ◽  
Ping Hao ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background: Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject.Results: To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells.Conclusions: A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

scholarly journals Redox-sensitive Polymeric Micelles With Aggregation-induced Emission for Bioimaging and Delivery of Anticancer Drugs

2020 ◽  
Author(s):  
Changzhen Sun ◽  
Ji Lu ◽  
Jun Wang ◽  
Ping Hao ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background: Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject.Results: To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells.Conclusions: A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

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