Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

2015 ◽  
Vol 51 (8) ◽  
pp. 1475-1478 ◽  
Author(s):  
Wang Xiao ◽  
Xuan Zeng ◽  
Hang Lin ◽  
Kai Han ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer

A dual stimuli-responsive multi-drug delivery system was developed for “cancer cocktail therapy”. Release behaviors of the dual drugs could be controlled separately by appropriate stimulation.

Preparation of biodegradable PEGylated pH/reduction dual-stimuli responsive nanohydrogels for controlled release of an anti-cancer drug

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 12051-12060 ◽  
Author(s):  
Tingting Zhou ◽  
Xubo Zhao ◽  
Lei Liu ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Stimuli Sensitive

Monodisperse biodegradable PEGylated pH and reduction dual-stimuli sensitive PMPB nanohydrogels were prepared as a drug delivery system for controlled release anti-cancer drugs.

scholarly journals Correction: Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17041-17041 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Receptor Targeting ◽  
Anti Cancer ◽  
Folate Receptor Targeting

Correction for ‘Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs’ by Xubo Zhao et al., RSC Adv., 2014, 4, 24232–24239.

Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24232-24239 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Ph Responsive ◽  
Anti Cancer ◽  
Folate Receptor Targeting

A novel graphene oxide (GO)-based nanocarrier has been designed for the targeting and pH-responsive controlled release of anti-cancer drugs.

A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch

2020 ◽  
Vol 11 (12) ◽  
pp. 2194-2204 ◽  
Author(s):  
Bingjie Hao ◽  
Wei Li ◽  
Sen Zhang ◽  
Ying Zhu ◽  
Yongjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Smart Drug ◽  
Smart Drug Delivery

A novel nanographene oxide/PEG-based bioreduction-responsive smart drug delivery system with a GSH-responsive disulfide linker as the controlled release switch can selectively release anti-cancer drugs in cancer cells.

Ultrasound-Based Drug Delivery System

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei-Wei Ren ◽  
Shi-Hao Xu ◽  
Li-Ping Sun ◽  
Kun Zhang
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Progress ◽  
Cancer Drugs ◽  
Nano Drug Delivery ◽  
Anti Cancer

: Cancer still represents a leading threat to human health worldwide. The effective usage of anti-cancer drugs can reduce patients’ clinical symptoms and extend the life span. Current anti-cancer strategies include chemotherapy, traditional Chinese medicine, biopharmaceuticals, and the latest targeted therapy. However, due to the complexity and heterogeneity of tumors, serious side effects may result from the direct use of anti-cancer drugs. Besides, the current therapeutic strategies failed to effectively alleviate metastasized tumors. Recently, an ultrasound-mediated nano-drug delivery system has become an increasingly important treatment strategy. Due to its ability to enhance efficacy and reduce toxic side effects, it has become a research hotspot in the field of biomedicine. In this review, we introduced the latest research progress of the ultrasound-responsive nano-drug delivery systems and the possible mechanisms of ultrasound acting on the carrier to change the structure or conformation as well as to realize the controlled release. In addition, the progress in ultrasound responsive nano-drug delivery systems will also be briefly summarized.

scholarly journals A Smart Core-Crosslinked Supramolecular Drug Delivery System (SDDS) Enabled by Pendant Cyclodextrins Encapsulation of Drug Dimers via Host-Guest Interaction

Biosensors ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 306
Author(s):  
Xin Xing ◽  
Zhijun Guo ◽  
Yue Su ◽  
Zhen Yang ◽  
Jiwen Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Micelles ◽  
Dynamic Equilibrium ◽  
Drug Loading ◽  
In Vitro Cytotoxicity ◽  
Stimuli Responsive ◽  
Anti Cancer

Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD) which crosslinked by stimuli-cleavable drug dimers via host-guest interaction. PEGylated PCD was precisely controlled synthesized by ring-opening polymerization and azide-alkyne click chemistry, and two doxorubicins (DOX) were linked with a disulfide bond to form a drug dimer (ss-DOX). They then co-assembled into supramolecular micelles. Drug dimers were utilized as cross-linkers to stabilize the micelles. The drug loading efficiency was very high that could be up to 98%. The size and morphology were measured by DLS and TEM. Owing to the disulfide bonds of drug dimers, these supramolecular micelles were dissociated by treating with dithiothreitol (DTT). In the meanwhile, the free DOXs were recovered and released from cavities of cyclodextrins because of dynamic equilibrium and hydrophilicity changes. The release profile was studied under mimic physiological conditions. Furthermore, in vitro cytotoxicity study showed excellent anti-cancer efficacy of reduced-responsive supramolecular polymeric micelles. Therefore, it can be served as a safe and stimuli-responsive SDDS for cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document