Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

Abstract Background: Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject.Results: To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells.Conclusions: A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

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Redox-sensitive Polymeric Micelles With Aggregation-induced Emission for Bioimaging and Delivery of Anticancer Drugs

10.21203/rs.3.rs-68528/v1 ◽

2020 ◽

Author(s):

Changzhen Sun ◽

Ji Lu ◽

Jun Wang ◽

Ping Hao ◽

Chunhong Li ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Cells ◽

Drug Delivery System ◽

Anticancer Drugs ◽

Delivery System ◽

Drug Delivery Systems ◽

Polymeric Micelles ◽

Delivery Systems ◽

Smart Drug ◽

Smart Drug Delivery

Abstract Background: Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject.Results: To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells.Conclusions: A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

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Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Nanomaterials ◽

10.3390/nano8080588 ◽

2018 ◽

Vol 8 (8) ◽

pp. 588 ◽

Cited By ~ 6

Author(s):

Xia Li ◽

Manpreet Sambi ◽

Alexandria DeCarlo ◽

Sergey V. Burov ◽

Roman Akasov ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Cancer Cells ◽

Drug Delivery System ◽

Delivery System ◽

Inner Core ◽

Hydrophobic Drug ◽

Alternating Copolymer ◽

Smart Drug ◽

Smart Drug Delivery

Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a “smart” drug delivery system to be specific for a tumour in vivo and to penetrate the inner core remains a major design challenge. These challenges can be overcome by using a study model that integrates the three-dimensional aspect of a tumour in a culture system. Here, we tested the efficacy of a functionalized folic acid-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA) to specifically target and penetrate the inner core of three-dimensional avascular human pancreatic and breast tumour spheroids in culture. The copolymer was quantitatively analyzed for its hydrophobic drug encapsulation efficiency using three different chemical drug structures with different molecular weights. Their release profiles and tumour targeting properties at various concentrations and pH environments were also characterized. Using the anticancer drug curcumin and two standard clinical chemotherapeutic hydrophobic drugs, paclitaxel and 5-fluorouracil, we tested the ability of FA-DABA-SMA nanoparticles to encapsulate the differently sized drugs and deliver them to kill monolayer pancreatic cancer cells using the WST-1 cell proliferation assay. The findings of this study revealed that the functionalized folic acid-conjugated amphiphilic alternating copolymer shows unique properties as an active “smart” tumor-targeting drug delivery system with the ability to internalize hydrophobic drugs and release the chemotherapeutics for effective killing of cancer cells. The novelty of the study is the first to demonstrate a functionalized “smart” drug delivery system encapsulated with a hydrophobic drug effectively targeting and penetrating the inner core of pancreatic and breast cancer spheroids and reducing their volumes in a dose- and time-dependent manner.

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A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch

Polymer Chemistry ◽

10.1039/d0py00110d ◽

2020 ◽

Vol 11 (12) ◽

pp. 2194-2204 ◽

Cited By ~ 1

Author(s):

Bingjie Hao ◽

Wei Li ◽

Sen Zhang ◽

Ying Zhu ◽

Yongjun Li ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Cancer Cells ◽

Drug Delivery System ◽

Delivery System ◽

Cancer Drugs ◽

Anti Cancer ◽

Smart Drug ◽

Smart Drug Delivery

A novel nanographene oxide/PEG-based bioreduction-responsive smart drug delivery system with a GSH-responsive disulfide linker as the controlled release switch can selectively release anti-cancer drugs in cancer cells.

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Lipid Based Vesicular Drug Delivery Systems

Advances in Pharmaceutics ◽

10.1155/2014/574673 ◽

2014 ◽

Vol 2014 ◽

pp. 1-12 ◽

Cited By ~ 17

Author(s):

Shikha Jain ◽

Vikas Jain ◽

S. C. Mahajan

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Polymeric Micelles ◽

Building Blocks ◽

Drug Action ◽

Delivery Systems ◽

The Body

Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.

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Unprecedented progresses of biomedical nanotechnology during conventional smart drug delivery systems (SDDSs) of francium nanoparticles in human gum cancer cells, tissues and tumors treatment under synchrotron radiation

Dental, Oral and Maxillofacial Research ◽

10.15761/domr.1000347 ◽

2020 ◽

Vol 6 (3) ◽

Author(s):

Alireza Heidari ◽

Katrina Schmitt ◽

Maria Henderson ◽

Elizabeth Besana

Keyword(s):

Drug Delivery ◽

Synchrotron Radiation ◽

Cancer Cells ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Smart Drug ◽

Smart Drug Delivery

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Janus Nano- and Microparticles as Smart Drug Delivery Systems

Current Pharmaceutical Biotechnology ◽

10.2174/1389201017666160401145438 ◽

2016 ◽

Vol 17 (8) ◽

pp. 673-682 ◽

Cited By ~ 4

Author(s):

Ibrahim M. El-Sherbiny ◽

Yasmine Abbas

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Smart Drug ◽

Smart Drug Delivery

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Diatom mediated smart drug delivery system

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102433 ◽

2021 ◽

Vol 63 ◽

pp. 102433

Author(s):

Sakshi Phogat ◽

Abhishek Saxena ◽

Neha Kapoor ◽

Charu Aggarwal ◽

Archana Tiwari

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Smart Drug ◽

Smart Drug Delivery

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Erratum: Corrigendum: Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma

Scientific Reports ◽

10.1038/srep44974 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 3

Author(s):

Peipei Xu ◽

Huaqin Zuo ◽

Bing Chen ◽

Ruju Wang ◽

Arsalan Ahmed ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Smart Drug ◽

Smart Drug Delivery

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Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽

10.3390/polym13081285 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1285

Author(s):

Louise Van Gheluwe ◽

Igor Chourpa ◽

Coline Gaigne ◽

Emilie Munnier

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Ex Vivo ◽

Delivery Systems ◽

Stimuli Responsive ◽

Stimuli Responsive Polymers ◽

Smart Drug ◽

Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

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