Water-soluble hyperbranched polyglycerol photosensitizer for enhanced photodynamic therapy

2020 ◽  
Vol 11 (23) ◽  
pp. 3913-3921
Author(s):  
Bowen Xiang ◽  
Yudong Xue ◽  
Zhiyong Liu ◽  
Jia Tian ◽  
Holger Frey ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
One Step ◽  
New Type ◽  
Hyperbranched Polyglycerol

Herein, we successfully fabricated a new type of water-soluble, hyperbranched polyglycerol photosensitizer through one-step esterification between water-soluble hyperbranched polyglycerol (hbPG) and fluorophenylporphyrin (FP).

One-Step Self-Assembly of ZnPc/KMnF3: Yb, Er upconversion Photodynamic Therapy System for Antibacterial Applications

NANO ◽  
2020 ◽  
Vol 15 (06) ◽  
pp. 2050075
Author(s):  
Xingqi Zhu ◽  
Deshuai Zhen ◽  
Chenyi Li ◽  
Ning Jiang ◽  
Hongchao Geng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Multidrug Resistant ◽  
Water Soluble ◽  
Confocal Imaging ◽  
Zinc Phthalocyanine ◽  
Great Promise ◽  
Oxygen Species ◽  
Gram Positive Bacteria ◽  
One Step

Photodynamic therapy (PDT) holds great promise as an effective approach to kill multidrug resistant (MDR) bacteria. In this study, KMnF3:Yb,Er upconversion nanoparticles (UCNPs) were prepared and modified with zinc phthalocyanine (ZnPc), a photosensitizer with a major absorption band at 670[Formula: see text]nm. ZnPc absorbs the emission at 660[Formula: see text]nm of the UCNPs producing reactive oxygen species (ROS) which kill the surrounding bacteria. The UCNPs were also modified with Tween to make them water-soluble and biocompatible, and oleylamine to provide positive charges to shorten the distance from bacteria. Detection of singlet oxygen production, bacteria viability test and confocal imaging were performed, respectively. The as-prepared system (UCNPs@ZnPc@Tween) shows enhanced efficiency of PDT against both Gram-negative and Gram-positive bacteria.

One-Step Preparation of a Water-Soluble Carbon Nanohorn/Phthalocyanine Hybrid for Dual-Modality Photothermal and Photodynamic Therapy

2014 ◽  
Vol 6 (20) ◽  
pp. 18008-18017 ◽  
Author(s):  
Bang-Ping Jiang ◽  
Lan-Fang Hu ◽  
Xing-Can Shen ◽  
Shi-Chen Ji ◽  
Zujin Shi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Dual Modality ◽  
One Step ◽  
Soluble Carbon

Graphene loading water-soluble phthalocyanine for dual-modality photothermal/photodynamic therapy via a one-step method

2014 ◽  
Vol 2 (41) ◽  
pp. 7141-7148 ◽  
Author(s):  
Bang-Ping Jiang ◽  
Lan-Fang Hu ◽  
Dong-Jin Wang ◽  
Shi-Chen Ji ◽  
Xing-Can Shen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hybrid Material ◽  
Copper Phthalocyanine ◽  
Water Soluble ◽  
Step Method ◽  
Dual Modality ◽  
One Step

In this paper, we present a new and facile one-step method for the fabrication of a water-soluble graphene-phthalocyanine (GR–Pc) hybrid material by simply sonicating GR with a hydrophilic Pc, tetrasulfonic acid tetrasodium salt copper phthalocyanine (TSCuPc).

One-step, ultrasonication-mobilized, solvent-free extraction/synthesis of nanocurcumin from turmeric

RSC Advances ◽  
2015 ◽  
Vol 5 (60) ◽  
pp. 48391-48398 ◽  
Author(s):  
Judy Gopal ◽  
Manikandan Muthu ◽  
Se-Chul Chun
Keyword(s):  
Solvent Free ◽  
Water Soluble ◽  
One Step

One step ultrasonication for direct recovery of water soluble nanocurcumin from turmeric.

Simple nanophotosensitizer fabrication using water-soluble chitosan for photodynamic therapy in gastrointestinal cancer cells

2017 ◽  
Vol 532 (1) ◽  
pp. 194-203 ◽  
Author(s):  
Young-IL Jeong ◽  
Byungyoul Cha ◽  
Hye Lim Lee ◽  
Yeon Hui Song ◽  
Yun Hye Jung ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Gastrointestinal Cancer ◽  
Water Soluble

Succinate Functionalization of Hyperbranched Polyglycerol-Coated Magnetic Nanoparticles as a Draw Solute During Forward Osmosis

2015 ◽  
Vol 15 (10) ◽  
pp. 8279-8284 ◽  
Author(s):  
Hee-Man Yang ◽  
Hye Min Choi ◽  
Sung-Chan Jang ◽  
Myeong Jin Han ◽  
Bum-Kyoung Seo ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Succinic Anhydride ◽  
Water Flux ◽  
Forward Osmosis ◽  
Feed Solution ◽  
Carboxyl Groups ◽  
Solute Leakage ◽  
One Step ◽  
Hyperbranched Polyglycerol ◽  
The One

Hyperbranched polyglycerol-coated magnetic nanoparticles (SHPG-MNPs) were functionalized with succinate groups to form a draw solute for use in a forward osmosis (FO). After the one-step synthesis of hyperbranched polyglycerol-coated magnetic nanoparticles (HPG-MNPs), the polyglycerol groups on the surfaces of the HPG-MNPs were functionalized with succinic anhydride moieties. The resulting SHPG-MNPs showed no change of size and magnetic property compared with HPGMNPs and displayed excellent dispersibility in water up to the concentration of 400 g/L. SHPG-MNPs solution showed higher osmotic pressure than that of HPG-MNPs solution due to the presence of surface carboxyl groups in SHPG-MNPs and could draw water from a feed solution across an FO membrane without any reverse draw solute leakage during FO process. Moreover, the water flux remained nearly constant over several SHPG-MNP darw solute regeneration cycles applied to the ultrafiltration (UF) process. The SHPG-MNPs demonstrate strong potential for use as a draw solute in FO processes.

Water-soluble dendritic polyaspartic porphyrins: potential photosensitizers for photodynamic therapy

2012 ◽  
Vol 36 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Baoxiang Gao ◽  
Yueling Liu ◽  
Huijuan Yin ◽  
Yingxin Li ◽  
Qianqian Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble

Syntheses and properties of acetylene-linked bis- and trisporphyrins toward two-photon photodynamic therapy

2007 ◽  
Vol 11 (06) ◽  
pp. 406-417 ◽  
Author(s):  
Yusuke Inaba ◽  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Cross Section ◽  
Sodium Salt ◽  
Absorption Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Photon Irradiation ◽  
Two Photon

Acetylene-bridged bisporphyrins and trisporphyrins having branched bulky bis(carboxylethyl)methyl meso-substituents were synthesized. These compounds showed large effective two-photon absorption cross-section values at 890 nm measured by using a nanosecond Z-scan method. Sodium salt of hydrolyzed trisporphyrins showed broad and red-shifted Q-bands over 900 nm. Two-photon absorption cross-section values of water-soluble dimers in water were similar to, or slightly larger than, those of ester forms evaluated in toluene. Furthermore, the generation of singlet oxygen upon one-photon irradiation for dimers in water was confirmed.

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