Diagnosis of Fatty Liver Disease by a Multiphoton-Active and Lipid-Droplet-Specific AIEgen with Nonaromatic Rotors

2021 ◽  
Author(s):  
Hojeong Park ◽  
Shijie Li ◽  
Guangle Niu ◽  
Haoke Zhang ◽  
Zhuo-yue Song ◽  
...  
Keyword(s):  
Liver Disease ◽  
Global Health ◽  
Health Risk ◽  
Fatty Liver ◽  
Lipid Droplet ◽  
Fatty Liver Disease ◽  
Early Stage ◽  
Accurate Diagnosis

Fatty liver disease (FLD) has become an increasing global health risk. However, an accurate diagnosis of FLD at an early stage remains a great challenge due to the lack of...

scholarly journals S1101 Non-Alcoholic Fatty Liver Disease: Is the FIB-4 Score Still Useful in Detecting Early-Stage Liver Fibrosis?

2021 ◽  
Vol 116 (1) ◽  
pp. S519-S520
Author(s):  
Shilpa Junna ◽  
Malini Chauhan ◽  
Michael Bonelli ◽  
Zachary Warner ◽  
Mark Borgstrom ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Early Stage ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Diagnosis of Fatty Liver Disease by a Bright, Multiphoton-Active and Lipid-Droplet-Specific AIEgen with Nonaromatic Rotors

2020 ◽  
Author(s):  
Hojeong Park ◽  
Shijie Li ◽  
Guangle Niu ◽  
Haoke Zhang ◽  
Zhuoyue Song ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Droplet ◽  
Fatty Liver Disease ◽  
Intramolecular Charge Transfer ◽  
Stokes Shift ◽  
Transfer Effect ◽  
Photon Absorption ◽  
Two Photon

Fatty liver disease (FLD) has become an increasing global health risk. However, an accurate diagnosis of FLD at an early stage remains a great challenge due to lack of suitable imaging tools. To this end, we developed the first fluorescent two-photon aggregationinduced emission (AIE) luminogen ABCXF for high-contrast imaging of FLD tissue. ABCXF has a large Stokes shift, good two-photon absorption cross-section, bright red emission, high fluorescence quantum yield in solid state, and excellent photostability. It shows abnormal intramolecular charge transfer effect instead of twisted intramolecular charge transfer effect in polar solvents. Photophysical and crystal data demonstrated that it exhibits nonaromatic rotors - trifluoromethyto contribute to its AIE effect. Biocompatible lipid droplet-targeting ABCXF can selectively light up lesions in the FLD tissue with a high signal-to-noise ratio. It shows superior imaging performances compared to Oil Red O. Thus, ABCXF can be a powerful tool for the diagnosis and evaluation of FLD from a liver biopsy.

scholarly journals Assessment of Liver Viscoelasticity for the Diagnosis of Early Stage Fatty Liver Disease Using Transient Elastography

2015 ◽  
Vol 70 ◽  
pp. 1246-1249
Author(s):  
Jean-Pierre Remenieras ◽  
Maelle Dejobert ◽  
Cécile Bastard ◽  
Véronique Miette ◽  
Jean-Marc Perarnau ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Early Stage
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