scholarly journals Organ-on-a-chip: the next generation platform for risk assessment of radiobiology

RSC Advances ◽  
2020 ◽  
Vol 10 (65) ◽  
pp. 39521-39530
Author(s):  
Yi Quan ◽  
Miao Sun ◽  
Zhaoyi Tan ◽  
Jan C. T. Eijkel ◽  
Albert van den Berg ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Animal Models ◽  
Low Dose ◽  
Risk Estimation ◽  
Next Generation ◽  
Internal Irradiation ◽  
Human Organs ◽  
Chip Technology ◽  
Organ On A Chip

Organ-on-a-chip technology has great potential for the next generation risk estimation of low dose internal irradiation, due to its success in mimicking human organs/tissues, which possibly can significantly improve on current animal models.

Cost effectiveness analysis of a next generation risk assessment score for cardiovascular disease

2013 ◽  
Vol 17 (2) ◽  
pp. 132-141
Author(s):  
Evangelos Hytopoulos ◽  
Martin L. Lee ◽  
Michael Beggs ◽  
Cynthia French ◽  
Kuo Bianchini Tong
Keyword(s):  
Cardiovascular Disease ◽  
Risk Assessment ◽  
Cost Effectiveness ◽  
Cost Effectiveness Analysis ◽  
Next Generation ◽  
Assessment Score ◽  
Effectiveness Analysis

Carcinogenic Risk Assessment of Complex Mixtures

1989 ◽  
Vol 5 (5) ◽  
pp. 851-867 ◽  
Author(s):  
D. Krewski ◽  
T. Thorslund ◽  
J. Withey
Keyword(s):  
Risk Assessment ◽  
Low Dose ◽  
Synergistic Effects ◽  
Carcinogenic Risk ◽  
Complex Mixtures ◽  
Multiple Exposures ◽  
Polycyclic Aromatic ◽  
Carcinogenic Substances ◽  
Carcinogenic Risk Assessment ◽  
Potential Use

Although procedures for assessing the carcinogenic risks associated with exposure to individual chemicals are relatively well developed, risk assessment methods for mixtures of chemicals are still in the developmental stage. In this paper, we examine the difficulties in assessing the risks of exposure to complex mixtures, with special reference to the potential for synergistic effects among the compo nents of the mixture. Statistical models for describing the joint action of multiple exposures are reviewed, and their implications for low-dose risk assessment are examined. The potential use of pharmacokinetic models to describe the metabolism of mixtures is also considered. Application of these results in regulating mixtures of carcinogenic substances is illustrated using examples involving multiple contaminants in drinking water and polycyclic aromatic hydrocarbons produced from combustion sources.

Next generation risk assessment for skin sensitization combining non-animal data and read-across:

2021 ◽  
Vol 350 ◽  
pp. S65
Author(s):  
F. Gautier ◽  
F. Tourneix ◽  
H. Assaf Vandecasteele ◽  
D Bury ◽  
N. Alépée
Keyword(s):  
Risk Assessment ◽  
Skin Sensitization ◽  
Next Generation ◽  
Animal Data

scholarly journals Small Force, Big Impact: Next Generation Organ-on-a-Chip Systems Incorporating Biomechanical Cues

2018 ◽  
Vol 9 ◽  
Author(s):  
Ece Ergir ◽  
Barbara Bachmann ◽  
Heinz Redl ◽  
Giancarlo Forte ◽  
Peter Ertl
Keyword(s):  
Next Generation ◽  
Small Force ◽  
Organ On A Chip

Hormesis is central to toxicology, pharmacology and risk assessment

2010 ◽  
Vol 29 (4) ◽  
pp. 249-261 ◽  
Author(s):  
Edward J Calabrese
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Low Dose ◽  
Assessment Practices ◽  
Biological Organization ◽  
Setting Process ◽  
Toxicological Research ◽  
Multiple Levels ◽  
Dose Responses ◽  
Chemical Class

This paper summarizes numerous conceptual and experimental advances over the past two decades in the study of hormesis. Hormesis is now generally accepted as a real and reproducible biological phenomenon, being highly generalized and independent of biological model, endpoint measured and chemical class/physical stressor. The quantitative features of the hormetic dose response are generally highly consistent, regardless of the model and mechanism, and represent a quantitative index of biological plasticity at multiple levels of biological organization. The hormetic dose-response model has been demonstrated to make far more accurate predictions of responses in low dose zones than either the threshold or linear at low dose models. Numerous therapeutic agents widely used by humans are based on the hormetic dose response and its low dose stimulatory characteristics. It is expected that as low dose responses come to dominate toxicological research that risk assessment practices will incorporate hormetic concepts in the standard setting process.

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