scholarly journals Advanced design and development of nanoparticle/microparticle dual-drug combination lactose carrier-free dry powder inhalation aerosols

RSC Advances ◽  
2020 ◽  
Vol 10 (68) ◽  
pp. 41846-41856
Author(s):  
Priya Muralidharan ◽  
Evan K. Mallory ◽  
Monica Malapit ◽  
Hanna Phan ◽  
Julie G. Ledford ◽  
...  
Keyword(s):  
Fluticasone Propionate ◽  
Spray Drying ◽  
Drug Combination ◽  
Dry Powder Inhalation ◽  
Dry Powders ◽  
High Performing ◽  
Salmeterol Xinafoate ◽  
Carrier Free ◽  
Molecular Mixtures ◽  
Dual Drug

Advanced co-spray drying of fluticasone propionate, salmeterol xinafoate, and d-mannitol leads to high-performing inhalable dry powders as molecular mixtures.

Formulation of novel dry powder inhalation for fluticasone propionate and salmeterol xinafoate with capsule-based device

2017 ◽  
Vol 23 (2) ◽  
pp. 158-166 ◽  
Author(s):  
Kyeong Soo Kim ◽  
Jeong Hyun Kim ◽  
Sung Giu Jin ◽  
Dong Wuk Kim ◽  
Jong Oh Kim ◽  
...  
Keyword(s):  
Fluticasone Propionate ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Salmeterol Xinafoate

Fragmented particles containing octreotide acetate prepared by spray drying technique for dry powder inhalation

2018 ◽  
Vol 8 (3) ◽  
pp. 693-701 ◽  
Author(s):  
Ailin Hou ◽  
Lu Li ◽  
Ying Huang ◽  
Vikramjeet Singh ◽  
Chune Zhu ◽  
...  
Keyword(s):  
Spray Drying ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Octreotide Acetate

Engineering Advances in Spray Drying for Pharmaceuticals

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
John M. Baumann ◽  
Molly S. Adam ◽  
Joel D. Wood
Keyword(s):  
Spray Drying ◽  
Oral Delivery ◽  
Process Development ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Annual Review ◽  
Publication Date ◽  
Dry Powders ◽  
Wide Range ◽  
Pharmaceutical Industries

Spray drying is a versatile technology that has been applied widely in the chemical, food, and, most recently, pharmaceutical industries. This review focuses on engineering advances and the most significant applications of spray drying for pharmaceuticals. An in-depth view of the process and its use is provided for amorphous solid dispersions, a major, growing drug-delivery approach. Enhanced understanding of the relationship of spray-drying process parameters to final product quality attributes has made robust product development possible to address a wide range of pharmaceutical problem statements. Formulation and process optimization have leveraged the knowledge gained as the technology has matured, enabling improved process development from early feasibility screening through commercial applications. Spray drying's use for approved small-molecule oral products is highlighted, as are emerging applications specific to delivery of biologics and non-oral delivery of dry powders. Based on the changing landscape of the industry, significant future opportunities exist for pharmaceutical spray drying. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 12 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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